| 词条 | TC OT 39 |
| 释义 |
| drug_name = | IUPAC_name = (2S)-N-[[4-[(4,10-dihydro-1-methylpyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]-2-methylphenyl]methyl]-2-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)thioxomethyl]-1-pyrrolidinecarboxamide | image = Compound39_oxytocin_agonist.png | width = 250 | alt = | caption = | tradename = | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_US = | pregnancy_category= | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 479232-57-0 | ATCvet = | ATC_prefix = none | ATC_suffix = | PubChem = | DrugBank = | ChemSpiderID = 23249746 | C=32 | H=40 | N=8 | O=2 | S=1 | molecular_weight = 600.78 g/mol | smiles = Cc1cc(ccc1CNC(=O)N2CCC[C@H]2C(=S)N3CCCN(CC3)C)C(=O)N4Cc5cnn(c5Nc6c4cccc6)C | StdInChI = 1S/C32H40N8O2S/c1-22-18-23(30(41)40-21-25-20-34-37(3)29(25)35-26-8-4-5-9-27(26)40)11-12-24(22)19-33-32(42)39-15-6-10-28(39)31(43)38-14-7-13-36(2)16-17-38/h4-5,8-9,11-12,18,20,28,35H,6-7,10,13-17,19,21H2,1-3H3,(H,33,42)/t28-/m0/s1 | StdInChIKey = KSNHHKZYKYNBEI-NDEPHWFRSA-N }}TC OT 39 is a non-peptide partial agonist of the oxytocin and vasopressin V2 receptors (Ki = 147 nM and >1000 nM, respectively) and antagonist of the vasopressin V1A receptor (Ki = 330 nM).[1] See also
References1. ^{{cite journal |vauthors=Pitt GR, Batt AR, Haigh RM, Penson AM, Robson PA, Rooker DP, Tartar AL, Trim JE, Yea CM, Roe MB | title = Non-peptide oxytocin agonists | journal = Bioorganic & Medicinal Chemistry Letters | volume = 14 | issue = 17 | pages = 4585–4589 | date = September 2004 | pmid = 15357997 | doi = 10.1016/j.bmcl.2004.04.107 | url = }} External links
7 : Benzodiazepines|Pyrrolidines|Benzamides|Oxytocin receptor agonists|Vasopressin receptor agonists|Vasopressin receptor antagonists|Thioamides |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。