| 词条 | Teflurane |
| 释义 |
| IUPAC_name = 2-Bromo-1,1,1,2-tetrafluoroethane | image = Teflurane.svg | width = 180 | CAS_number = 124-72-1 | ATC_prefix = None | ATC_suffix = | PubChem = 31300 | DrugBank = | ChemSpiderID = 29040 | C=2 | H=1 | Br=1 | F=4 | molecular_weight = 180.927 g/mol | smiles = C(C(F)(F)F)(F)Br | StdInChI = 1S/C2HBrF4/c3-1(4)2(5,6)7/h1H | StdInChIKey = RZXZIZDRFQFCTA-UHFFFAOYSA-N | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | pregnancy_AU = | pregnancy_US = | pregnancy_category= | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = }}Teflurane (INN, USAN, code name Abbott 16900) is a halocarbon drug which was investigated as an inhalational anesthetic but was never marketed.[1][2] Its clinical development was terminated due to a high incidence of cardiac arrhythmias in patients, similarly to the cases of halopropane and norflurane.[3] ChemistryTeflurane is 2-bromo-1,1,1,2-tetrafluoroethane, a haloalkane. It is a gas at standard conditions.[4] The compound is chiral. See also
References1. ^{{cite book|author=Sanford L. Klein|title=A glossary of anesthesia and related terminology|url=https://books.google.com/books?id=gF9qAAAAMAAJ|year=1993|publisher=Springer-Verlag|isbn=978-0-387-97831-4}} {{General anesthetics}}{{GABAAR PAMs}}{{nervous-system-drug-stub}}2. ^{{cite book|author1=Joseph Francis Artusio|author2=Valentino D. B. Mazzia|title=Practical anesthesiology|url=https://books.google.com/books?id=hGtsAAAAMAAJ|year=1962|publisher=Mosby}} 3. ^{{cite book|author1=T.H. Stanley|author2=W.C. Petty|title=Anesthesia, The Heart and the Vascular System: Annual Utah Postgraduate Course in Anesthesiology 1987|url=https://books.google.com/books?id=s3OhBQAAQBAJ&pg=PT185|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-94-009-3295-1|pages=185–}} 4. ^http://www.chemspider.com/Chemical-Structure.21235115.html 5 : General anesthetics|Organobromides|Organofluorides|GABAA receptor positive allosteric modulators|Trifluoromethyl compounds |
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