“Teva Active Pharmaceutical Ingredients”的意思、由来-开放百科全书

On top of supplying a major share of Teva's own needs, the TAPI division is an active competitor in world markets, investing both in the development of new products and manufacturing processes and in the upgrading of production facilities. In 2014, TAPI's sales to third parties totaled $724 million. In recent years growth occurred in all of TAPI's principal geographical markets: North America, Europe and International.^[3] As of 2013, Teva Active Pharmaceutical Ingredients employs over 5,000 professionals worldwide, and offers a rich portfolio of about 300 active pharmaceutical ingredients.

History

At the heart of the API division is the Israel-based Teva-Tech, formerly known as the Assia and Plantex plants which manufacture, develop and market raw materials for pharmaceuticals.

Acquisitions

TAPI has grown by acquiring top rated manufacturing and development facilities around the world. Today, TAPI operates 21 plants worldwide. Major TAPI’s acquisitions:

Facilities

Research and development

The R&D group at TAPI consists of a team of over 760 top scientists located in 7 development centers worldwide: A large center in Israel (synthetic products and peptides), a large center in Hungary (fermentation and semi-synthetic products), and a facility in India and additional sites in Italy, Croatia, Mexico and the Czech Republic (development of high potency API).

TAPI's R&D focuses on the development of processes for the manufacturing of API, including intermediates, chemical and biological (fermentation), which are of interest to the generic drug industry, as well as Teva's proprietary drugs. The API R&D division also seeks methods to continuously reduce API production costs, enabling TAPI to improve its cost structure.

Manufacturing and technology

Teva has 21 API production facilities located in Israel, Hungary, Italy, the U.S., the Czech Republic, India, Mexico, Puerto Rico, Monaco, China and Croatia.^[8] TAPI’s holds expertise in a variety of production technologies, including chemical synthesis, semi-synthetic fermentation, enzymatic synthesis, high potent manufacturing, plant extract technology, synthetic peptides, vitamin D derivatives and prostaglandins. Also, its advanced technology and expertise in the field of solid state particle technology enables it to meet specifications for particle size distribution (PSD), bulk density, specific surface area, polymorphism, as well as other characteristics.^[9]

Teva’s API facilities meet all applicable current Good Manufacturing Practices (cGMP) requirements under U.S., European, Japanese, and other applicable quality standards. In some of the products that are sold in the U.S., TAPI utilizes controlled substances and therefore must meet the requirements of the Controlled Substances Act and the related regulations administered by the Drug Enforcement Administration.^[10]

Products

TAPI produces approximately 300 active pharmaceutical ingredients covering a wide range of products, including respiratory, cardiovascular, anti-cholesterol, central nervous system, dermatological, hormones, anti-inflammatory, oncology, immunosuppressants and muscle relaxants. Its API intellectual property portfolio includes over 1,200 granted patents and pending applications worldwide.^[11]

See also

References

1. ^{{cite web|url=https://www.reuters.com/finance/stocks/companyProfile?rpc=66&symbol=TEVA.K|title=Teva Pharmaceutical Industries Ltd (TEVA.K)|publisher=Reuters Finance|date= |accessdate=2012-06-12}}
2. ^{{cite web|url=http://markets.on.nytimes.com/research/stocks/news/press_release.asp?docTag=201205301332BIZWIRE_USPRX____BW6365&feedID=600&press_symbol=269944&scp=5&sq=teva%20pharmaceutical&st=Search|title=Leading Global Pharmaceutical Company, Teva Pharmaceutical Industries, Transfers Stock Listing to the New York Stock Exchange from NASDAQ|publisher=The New York Times|date= |accessdate=2012-06-12}}
3. ^{{cite web|url=http://ir.tevapharm.com/phoenix.zhtml?c=73925&p=irol-reportsAnnual |title=TEVA - Investor Relations (IR) - Quarterly and Annual Reports |publisher=Ir.tevapharm.com |date= |accessdate=2012-05-20}}
4. ^{{cite web|url=http://www.merck.de/en/media/extNewsDetail.html?newsId=A52969A174686390C12577CA003EB758&newsType=1 |title=The Merck Group - News Detail |publisher=Merck.de |date=2010-10-28 |accessdate=2012-05-20}}
5. ^Jennifer Bayot for the New York Times. July 26, 2005 [https://www.nytimes.com/2005/07/26/business/teva-to-acquire-ivax-another-maker-of-generic-drugs.html?_r=0 Teva to Acquire Ivax, Another Maker of Generic Drugs]
6. ^Teva Press Release, 2006. Teva Completes Acquisition of Ivax
7. ^{{cite web|url=http://www.tapi.com |title=Teva Active Pharmaceutical Ingredients |publisher=TAPI |date= |accessdate=2012-05-20}}
8. ^{{cite web|url=http://www.wikinvest.com/stock/Teva_Pharmaceutical_Industries_(TEVA)/Active_Pharmaceutical_Ingredients_Api|title=Teva Pharmaceutical Industries (TEVA)- Active Pharmaceutical Ingredients ("API")|publisher=Wikiinvest |date= |accessdate=2012-06-13}}
9. ^{{cite web|url=http://www.worldpharmaceuticals.net/marketresources/013_march08/WPF013%20030%20teva.htm|title=Ingredients for Success|publisher=World Pharmaceuticals Frontiers |date= |accessdate=2012-06-13}}
10. ^{{cite web|url=http://www.worldpharmaceuticals.net/marketresources/016_sept09/WPF016_tapi.htm |title=World Pharmaceutical Frontiers |publisher=World Pharmaceuticals Frontiers.|date= |accessdate=2012-05-20}}
11. ^{{cite web|url=http://www.tapi.com/Public/Documents/tapi%20product%20catalogue.pdf|title=TAPI Product Catalogue, January 2012 |publisher=TAPI |date= |accessdate=2012-06-12}}