Costas Simitis served as a Prime Minister of Greece for three consecutive terms (1996-2004), at the head of the Panhellenic Socialist Movement (PASOK). His third cabinet was formed after the 2000 elections and was succeeded by the first cabinet of Kostas Karamanlis (New Democracy).
| Office | Incumbent | Since |
|---|
| Prime Minister | Costas Simitis | 13 April 2000 |
| Minister for Foreign Affairs | George Papandreou | 13 April 2000 |
| replaced by}} | Tasos Giannitsis|de}} | 13 February 2004 (interim) |
| Minister for National Defence | Akis Tsochatzopoulos | 13 April 2000 |
| replaced by}} | Yiannos Papantoniou | 24 October 2001 |
| Minister for the Interior, Public Administration and Decentralization | Vasso Papandreou|de}} | 13 April 2000 |
| replaced by}} | Kostas Skandalidis | 24 October 2001 |
| replaced by}} | Nikos Alivizatos | 13 February 2004 (interim) |
| Minister of Economy and Finance | Yiannos Papantoniou | 13 April 2001 |
| replaced by}} | Nikos Christodoulakis | 24 October 2001 |
| Minister for Justice | Michalis Stathopoulos|el|3=Μιχαήλ Σταθόπουλος}} | 13 April 2000 |
| replaced by}} | Filippos Petsalnikos | 24 October 2001 |
| Minister for the Environment, Physical Planning and Public Works | Kostas Laliotis|el|3=Κώστας Λαλιώτης}} | 13 April 2000 |
| replaced by}} | Vasso Papandreou|de}} | 24 October 2001 |
| Minister for National Education and Religious Affairs | Petros Efthymiou | 13 April 2000 |
| Minister for Transport and Communications | Christos Verelis | 13 April 2000 |
| Minister of Labour and Social Solidarity | Tasos Giannitsis|de}} | 13 April 2000 |
| replaced by}} | Dimitris Reppas | 24 October 2001 |
| Minister for Health and Social Security | Alekos Papadopoulos|el|3=Αλέκος Παπαδόπουλος (πολιτικός)}} | 13 April 2000 |
| replaced by}} | Konstantinos Stefanis|el|3=Κωνσταντίνος Στεφανής}} | 13 June 2002 |
| Minister for Agriculture | Giorgos Anomeritis|el|3=Γιώργος Ανωμερίτης}} | 13 April 2000 |
| replaced by}} | Georgios Drys|el|3=Γεώργιος Δρυς}} | 24 October 2001 |
| Minister for Public Order | Michalis Chrisochoidis | 13 April 2000 |
| replaced by}} | Giorgos Floridis|de}} | 7 July 2003 |
| Minister for Culture | Theodoros Pangalos | 13 April 2000 |
| replaced by}} | Evangelos Venizelos | 20 November 2000 |
| Minister for Culture | Christos Papoutsis | 13 April 2000 |
| replaced by}} | Evangelos Venizelos | 20 November 2000 |
| Minister for Development | Nikos Christodoulakis | 13 April 2000 |
| replaced by}} | Akis Tsochatzopoulos | 24 October 2001 |
| Minister for Mercantile Marine | Christos Papoutsis | 13 April 2000 |
| replaced by}} | Giorgos Anomeritis|el|3=Γιώργος Ανωμερίτης}} | 24 October 2001 |
| replaced by}} | Georgios Paschalidis | 7 July 2003 |
| Minister for the Press and the Media | Dimitris Reppas | 13 April 2000 |
| replaced by}} | Christos Protopapas|el|3=Χρήστος Πρωτόπαπας}} | 24 October 2001 |
| replaced by}} | Georgios Romaios|el|3=Γεώργιος Ρωμαίος}} | 13 February 2004 (interim) |
| Minister for Macedonia and Thrace | Georgios Paschalidis | 13 April 2000 |
| replaced by}} | Haris Kastanidis | 7 July 2003 |
| Minister for the Aegean | Nikolaos Sifounakis | 13 April 2000 |
| Minister of State | Miltiadis Papaioannou | 13 April 2000 |
| replaced by}} | Stefanos Manikas | 24 October 2001 |
| replaced by}} | Alexandros Akrivakis|el|3=Αλέξανδρος Ακριβάκης}} | 7 July 2003 |
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