| 词条 | Thomas Kilduff |
| 释义 |
|name = Thomas Kilduff |image = |image_size = |alt = |caption = |birth_date = |birth_place = |death_date = |death_place = |residence = |citizenship = |nationality = |ethnicity = |fields = Neuroscience, particularly the neurobiology of sleep and wakefulness |workplaces = Ames Research Center Stanford University School of Medicine SRI International |alma_mater = University of Florida Stanford University |doctoral_advisor = |academic_advisors = Wilse B. Webb, Craig Heller, Bill A. Williams, William C. Dement |doctoral_students = |notable_students = |known_for = Discovery of hypocretin |author_abbrev_bot = |author_abbrev_zoo = |influences = |influenced = |awards = 2009 AAAS Fellow |footnotes = }}Thomas S. Kilduff is an American neuroscientist and the director of SRI International's Center for Neuroscience. He specializes in neurobiology related to sleep and wakefulness, and was involved in the discovery of hypocretin (also known as orexin),[1][2] a neuropeptide system that is highly involved in wakefulness regulation.[3][4][5] His group at SRI International also discovered an unusual neuronal population in the cerebral cortex that is activated during sleep.[6][7][8] He is also a consulting professor at the Stanford University School of Medicine's Department of Psychiatry and Behavioral Sciences.[3] EducationKilduff obtained a B.S. from the University of Florida and earned an M.S. and a Ph.D. in biological sciences from Stanford University, where he was also awarded fellowships from the Danforth Foundation, the Grass Foundation, and the National Science Foundation.[9] CareerKilduff was a senior research scientist at Stanford University's Center for Sleep and Circadian Neurobiology.[9] He was also a visiting scientist in the Scripps Research Institute's Department of Molecular Biology, a visiting professor at the University of Perugia's Istituto di Biologia Cellulare, and a National Academy of Sciences National Research Council research associate at NASA's Ames Research Center.[10] In 1999, Kilduff joined SRI International as part of a new molecular neurobiology group, where he subsequently founded the Sleep Neurobiology Program before becoming director of the Center for Neuroscience.[10][11] ResearchKilduff's early research focused on the neural control of mammalian hibernation[12][13][14] and circadian rhythms.[15] [16][17]Kilduff and scientists at the Scripps Research Institute co-discovered hypocretin (also known as orexin), a neuropeptide system that is involved in the control of wakefulness.[11] Subsequent research established that the hypocretin neurons degenerate in the sleep disorder narcolepsy and is the likely cause of this disorder.[18][19] Awards and membershipsHe was named a Fellow Member of the American Association for the Advancement of Science in the December 18, 2009 issue of Science.[9][20] He was named an SRI Fellow in 2010 [3] and a Distinguished Scientist by the SRS in 2017.[21] He is a member of the Society for Neuroscience has served on the boards of the Associated Professional Sleep Societies, the Sleep Research Society, and was a Founding Member of the Sleep Research Society Foundation.[11][22] See also
References1. ^{{cite journal|author=de Lecea, L.|author2=Kilduff, T.S.|author3=Peyron, C.|author4=Gao, X.-B.|author5=Foye, P.E.|author6=Danielson, P.E.|author7=Fukuhara, C.|author8=Battenberg, E.L.F.|author9=Gautvik, V.T.|author10=Bartlett II, F.S.|year=1998|title=The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity|journal=Proceedings of the National Academy of Sciences USA|volume=95|pages=322–327|pmid=9419374|issue=1, number 1 |pmc=18213|doi=10.1073/pnas.95.1.322|display-authors=etal}} {{DEFAULTSORT:Kilduff, Thomas S}}2. ^{{cite journal|author=Sakurai, T.|author2=Amemiya, A.|author3=Ishii, M.|author4=Matsuzaki, I.|author5=Chemelli, R.M.|author6=Tanaka, H.|author7=Williams, S.C.|author8=Richardson, J.A.|author9=Kozlowski, G.P.|author10=Wilson, S.|year=1998|title=Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior|journal=Cell|volume=92|pages=573–585|pmid=9491897|issue=4, number 4|doi=10.1016/S0092-8674(00)80949-6|display-authors=etal}} 3. ^1 2 {{cite web|url=http://www.sri.com/about/people/thomas-kilduff|title=Our People: Thomas Kilduff|publisher=SRI International|accessdate=2013-04-28}} 4. ^{{cite journal|url=http://www.jneurosci.org/content/28/46/11814.full|title=New Developments in Sleep Research: Molecular Genetics, Gene Expression, and Systems Neurobiology|author=Thomas S. Kilduff|author2=Ed S. Lein|author3=Horacio de la Iglesia|author4=Takeshi Sakurai|author5=Ying-hui Fu|author6=Paul Shaw|last-author-amp=yes|journal=The Journal of Neuroscience|date=2008-11-12|issue=46|volume=28|pages=11814–11818|doi=10.1523/jneurosci.3768-08.2008|pmid=19005045|pmc=2628168}} 5. ^{{cite journal|author=Kilduff, T.S.|author2=Peyron, C.|last-author-amp=yes|year=2000|title=The hypocretin/orexin ligand-receptor system: Implications for sleep and sleep disorders|journal=Trends in Neurosciences|volume=23|pages=359–365|pmid=10906799|issue=8, number 8|doi=10.1016/s0166-2236(00)01594-0}} 6. ^{{cite news|url=http://www.sri.com/newsroom/press-releases/sri-international-research-team-identifies-rare-sleep-activated-neurons-ce-0|title=SRI International Research Team Identifies Rare Sleep-Activated Neurons in the Cerebral Cortex|publisher=SRI International|date=2008-07-21|accessdate=2013-06-15}} 7. ^{{cite journal|author=Gerashchenko, D.|author2=Wisor, J.P.|author3=Burns, D.|author4=Reh, R.K.|author5=Shiromani, P.J.|author6=Sakurai, T.|author7=de la Iglesia, H.O.|author8=Kilduff, T.S|last-author-amp=yes|year=2008|title=Identification of a population of sleep-active cerebral cortex neurons|url=http://www.pnas.org/content/105/29/10227.short|journal=Proceedings of the National Academy of Sciences USA|volume=105|number=29|pages=10227–10232|doi=10.1073/pnas.0803125105|pmc=2481371}} 8. ^{{cite journal|author=Kilduff, T.S.|author2=Cauli, B.|author3=Gerashchenko, D.|last-author-amp=yes|year=2011|title=Activation of cortical interneurons during sleep: an anatomical link to homeostatic sleep regulation?|journal=Trends in Neurosciences|volume=34|pages=10–19|pmid=21030095|doi=10.1016/j.tins.2010.09.005|issue=1, number 1|pmc=3014438}} 9. ^1 2 {{cite news|url=http://www.sri.com/newsroom/press-releases/sri-international-researcher-named-american-association-advancement-science-|title=SRI International Researcher Named American Association for the Advancement of Science (AAAS) Fellow|publisher=SRI International|date=2010-01-20|accessdate=2013-04-28}} 10. ^1 {{cite news|url=http://www.sri.com/news/releases/1-25-99.html|archivedate=2000-07-09|archiveurl=https://web.archive.org/web/20000709151940/http://www.sri.com/news/releases/1-25-99.html|title=Stanford Scientist Thomas Kilduff Joins SRI International as Senior Program Director of Newly Formed Molecular Neurology Group|publisher=SRI International|date=1999-01-25|accessdate=2013-04-28}} 11. ^1 2 {{cite web|url=http://www.sleepresearchsociety.org/PDFs/Candidates/Kilduff.pdf|title=Candidate: President Elect: Thomas Kilduff, PhD|publisher=Sleep Research Society|accessdate=2013-04-2013}} 12. ^{{cite journal |vauthors=Kilduff TS, Bowersox SS, Faull KF, etal |title=Modulation of activity of the striatal dopaminergic system during the hibernation cycle|journal=Neuroscience|year=1987|issue=7|pages=2732–2736}} 13. ^{{cite journal|vauthors=Kilduff TS, Miller JD, Radeke CM, Sharp FR, Heller HC|title=14C-2-deoxyglucose uptake in the ground squirrel brain during entrance to and arousal from hibernation|journal=Neuroscience|year=1990|issue=10|pages=2463–2475}} 14. ^{{cite journal|vauthors=Kilduff TS, Sharp FR, Heller HC|title=[14C]2-deoxyglucose uptake in ground squirrel brain during hibernation|journal=Neuroscience|year=1982|issue=2|pages=143–157}} 15. ^{{cite journal |vauthors=Kilduff TS, Vugrinic C, Lee SL, etal |title=Characterization of the circadian system of NGFI-A and NGFI-A/NGFI-B deficient mice|journal=Journal of Biological Rhythms|year=1998|issue=13|pages=347–357}} 16. ^{{cite journal|vauthors=Sutin EL, Dement WC, Heller HC, Kilduff TS|title=Light-induced gene expression in the suprachiasmatic nucleus of young and aging rats|journal=Neurobiology of Aging|year=1993|issue=14|pages=441–446}} 17. ^{{cite journal|vauthors=Sutin EL, Kilduff TS|title=Circadian and light-induced expression of immediate early gene mRNAs in the rat suprachiasmatic nucleus|journal=Molecular Brain Research|year=1992|issue=15|pages=281–290}} 18. ^{{cite journal|author=Peyron, C.|author2=Faraco, J.|author3=Rogers, W.|author4=Ripley, B.|author5=Overeem, S.|author6=Charnay, Y.|author7=Nevsimalova, S.|author8=Aldrich, M.|author9=Reynolds, D.|author10=Albin, R.|year=2000|title=A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains|journal=Nature Medicine|volume=6|pages=991–997|pmid=10973318|doi=10.1038/79690|issue=9, number 9|display-authors=etal}} 19. ^{{cite journal|author=Thannickal, T.|author2=Moore, R.|author3=Y., Nienhuis|author4=R., Ramanathan|author5=L., Gulyani|author6=S., Aldrich|author7=M., Cornford, M.|author8=Siegel, J.M.|last-author-amp=yes|year=2000|title=Reduced number of hypocretin neurons in human narcolepsy|journal=Neuron|volume=27|pages=469–474|pmid=11055430|issue=3, number 3|doi=10.1016/s0896-6273(00)00058-1}} 20. ^{{cite web|url=http://membercentral.aaas.org/fellows?page=2&LastName_3=&Section=V&Country=&State=|title=Fellows|publisher=American Association for the Advancement of Science|accessdate=2013-04-28}} 21. ^{{cite web|title=Distinguished Scientist Award|url=http://www.sleepresearchsociety.org/Distinguishedscientist.aspx|publisher=Sleep Research Society|ref=23}} 22. ^{{cite web|url=http://www.frontiersin.org/Community/WhosWhoDetails.aspx?UID=9360&526&sname=thomaskilduff|title=Thomas Kilduff|publisher=Frontiers|accessdate=2013-07-28}} 10 : Living people|University of Florida alumni|Stanford University alumni|SRI International people|Place of birth missing (living people)|Fellows of the American Association for the Advancement of Science|American neurologists|Sleep researchers|Scientists from the San Francisco Bay Area|Year of birth missing (living people) |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。