| 词条 | Tn antigen |
| 释义 |
Tn antigen refers to the monosaccharide structure N-acetylgalactosamine (GalNAc) linked to serine or threonine by a glycosidic bond.[1] Addition of an additional galactose monosaccharide creates a disaccharide antigen: the Thomsen-Friedenreich antigen (Gal(b1-3)GalNAc). The sialyl Tn antigen (STn antigen) is formed by elongation with sialic acid (Neu5Ac(a2-6)GalNAc) rather than galactose. References1. ^I. Brockhausen, H. Schachter, P. Stanley, Essentials of Glycobiology, 2nd edition. A. Varki, R. Cummings, J. Esko, Eds, Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009. Chapter 9, O-GalNAc Glycans 2 : Oncology|Immune system |
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