| 词条 | Tofenacin |
| 释义 |
| IUPAC_name = N-methyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine | image = Tofenacin_structure.png |tradename= Elamol, Tofacine, Tofalin |USAN=tofenacin hydrochloride | CAS_number = 15301-93-6 | CAS_supplemental = 10488-36-5 (HCl) | ATC_prefix = None | ATC_suffix = | PubChem = 25315 | ChemSpiderID = 23647 | C=17 | H=21 | N=1 | O=1 | molecular_weight = 255.355 g/mol | SMILES = O(CCNC)C(c1ccccc1)c2ccccc2C | StdInChI = 1S/C17H21NO/c1-14-8-6-7-11-16(14)17(19-13-12-18-2)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3 | StdInChIKey = PNYKGCPSFKLFKA-UHFFFAOYSA-N | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | pregnancy_category = | legal_status = Rx-only | routes_of_administration = By mouth }}Tofenacin is an antidepressant drug with a tricyclic-like structure which was developed and marketed in the United Kingdom and Italy in 1971 and 1981, respectively, by Brocades-Stheeman & Pharmacia (now part of Astellas Pharma).[1][2][3] It acts as a serotonin-norepinephrine reuptake inhibitor,[4] and based on its close relation to orphenadrine, may also possess anticholinergic and antihistamine properties. Tofenacin is also the major active metabolite of orphenadrine and likely plays a role in its beneficial effects against depressive symptoms seen in Parkinson's disease patients.[5][6] See also
References1. ^{{cite book | title = Index Nominum 2000: International Drug Directory | url = https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA1041 | accessdate = 19 May 2012 | year = 2000 | publisher = Taylor & Francis US | isbn = 978-3-88763-075-1 | page = 1041}} {{Antidepressants}}{{Navboxes2. ^{{cite book | author = J. Buckingham | title = Dictionary of organic compounds: Chemical Abstracts Service registry number index | url = https://books.google.com/books?id=2Ggj1SncMBEC&pg=PA6074 | accessdate = 19 May 2012 | year = 1996 | publisher = CRC Press | isbn = 978-0-412-54090-5 | page = 6074}} 3. ^{{cite book | title = Pharmaceutical Manufacturing Encyclopedia, 3rd Edition | url = https://books.google.com/books?id=TIu28TH_iAYC&pg=PA3268 | accessdate = 19 May 2012 | publisher = Elsevier | isbn = 978-0-8155-1526-5 | page = 3268}} 4. ^{{cite book | author1 = Gwynn Pennant Ellis | author2 = Geoffrey Buckle West | title = Progress in Medicinal Chemistry | url = https://books.google.com/books?id=YN9YWk4T4fwC&pg=PA284 | accessdate = 19 May 2012 | date = 1 January 1978 | publisher = Elsevier | isbn = 978-0-7204-0655-9 | page = 284}} 5. ^{{cite journal |vauthors=Capstick N, Pudney H | title = A comparative trial of orphenadrine and tofenacin in the control of depression and extrapyramidal side-effects associated with fluphenazine decanoate therapy | journal = The Journal of International Medical Research | volume = 4 | issue = 6 | pages = 435–40 | year = 1976 | pmid = 800383 | doi = | url = }} 6. ^{{cite journal |vauthors=Altamura AC, Mauri MC, De Novellis F, Percudani M, Vampini V | title = Residual neuroleptic-induced parkinsonian symptoms in schizophrenia. A naturalistic study with orphenadrine | journal = Pharmacopsychiatry | volume = 22 | issue = 6 | pages = 246–9 |date=November 1989 | pmid = 2616635 | doi = 10.1055/s-2007-1014608| url = }} | title = Pharmacodynamics | titlestyle = background:#ccccff | list1 ={{Histamine receptor modulators}}{{Monoamine reuptake inhibitors}}{{Muscarinic acetylcholine receptor modulators}} }}{{Nervous-system-drug-stub}} 7 : Abandoned drugs|Amines|Astellas Pharma|Bicyclic antidepressants|Ethers|Muscarinic antagonists|Serotonin-norepinephrine reuptake inhibitors |
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