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词条 Toponomics
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Toponomics is a discipline in systems biology, molecular cell biology, and histology.[1][2] It concerns the study of the toponome of organisms. The toponome is the spatial network code of proteins and other biomolecules in morphologically intact cells and tissues.[2][3] The terms toponome and toponomics were introduced by Walter Schubert in 2003[1] based on observations with imaging cycler microscopes (ICM). The term “toponome” is derived from the ancient Greek nouns “topos” (τόπος; place, position) and “nomos” (νόμος; law). Hence the term toponomics is descriptive term addressing the fact that the spatial network of biomolecules in cells follows topological rules enabling coordinated actions.[1] This spatial organization is directly revealed by imaging cycler microscopy with parameter- and dimension-unlimited functional resolution. The resulting toponome structures are hierarchically organized and can be described by a three symbol code.[1][3][4][5] Toponomics is the field of study that has at its goal to decode the complete toponome in health and disease (The human toponome project[6]) – the next big challenge in human biotechnology after having decoded the human genome.[6][7]

Citations

1. ^1 2 3 {{cite book|last=Schubert|first=W|title=Topological Proteomics, Toponomics, MELK-Technology.|journal=Advances in Biochemical Engineering/Biotechnology|year=2003|volume=83|pages=189–209|doi=10.1007/3-540-36459-5_8|isbn=978-3-540-00546-9}}
2. ^1 {{cite book|last=Schubert|first=W|title="Toponomics" in Dubitzky, Wolkenhauer, Cho, Yokota. Encyclopedia of Systems Biology|year=2013|publisher=Springer New York|isbn=978-1-4419-9862-0|pages=2191–2212|doi=10.1007/978-1-4419-9863-7_631|chapter=Toponomics}}
3. ^1 {{cite journal|last=Schubert|first=Walter|author2=Bonnekoh, Bernd |author3=Pommer, Ansgar J |author4=Philipsen, Lars |author5=Böckelmann, Raik |author6=Malykh, Yanina |author7=Gollnick, Harald |author8=Friedenberger, Manuela |author9=Bode, Marcus |author10= Dress, Andreas W M |title=Analyzing proteome topology and function by automated multidimensional fluorescence microscopy|journal=Nature Biotechnology|date=1 October 2006|volume=24|issue=10|pages=1270–1278|doi=10.1038/nbt1250 |pmid=17013374}}
4. ^{{cite journal|last=Schubert|first=Walter|title=A three-symbol code for organized proteomes based on cyclical imaging of protein locations|journal=Cytometry Part A|date=June 2007|volume=71A|issue=6|pages=352–360|doi=10.1002/cyto.a.20281|pmid=17326231}}
5. ^{{cite web|last=Schubert|first=W|title=Direct, spatial imaging of randomly large supermolecules by using parameter unlimited TIS imaging cycler microscopy.|url=http://www.toposnomos.com/doku/MC2013.pdf|publisher=International Microscopy Conference 2013|accessdate=2013-09-23}}
6. ^1 {{cite journal|last=Cottingham|first=Katie|title=Human Toponome Project {{!}} Human Proteinpedia is open for (free) business|journal=Journal of Proteome Research|date=May 2008|volume=7|issue=5|pages=1806|doi=10.1021/pr083701k}}
7. ^{{cite journal|last=Abott|first=A|title="Mapping togetherness" (research highlight referring to Schubert et al. 2006)|journal=Nature|date=12 October 2006|volume=443|issue=7112|pages=608–609|doi=10.1038/443608a|bibcode=2006Natur.443..608.}}

3 : Systems biology|Omics|Topology
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