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词条 Toothpaste
释义

  1. Usefulness

  2. Ingredients

     Abrasives  Fluorides  Surfactants  Other components  Antibacterial agents  Flavorants  Remineralizers  Miscellaneous components   Xylitol  

  3. Safety

     Fluoride  Diethylene glycol  Triclosan   Polyethylene glycol - PEG   Miscellaneous issues and debates  Alteration of taste perception  Whitening toothpastes  Herbal and natural toothpastes 

  4. Striped toothpaste

  5. History

     Early toothpastes  Tooth powder  Modern toothpaste  Toothpaste tubes 

  6. See also

  7. References

  8. Further reading

  9. External links

{{pp-move-indef|small=yes}}{{Use mdy dates|date=April 2013}}Toothpaste is a paste or gel dentifrice used with a toothbrush to clean and maintain the aesthetics and health of teeth. Toothpaste is used to promote oral hygiene: it is an abrasive that aids in removing dental plaque and food from the teeth, assists in suppressing halitosis, and delivers active ingredients (most commonly fluoride) to help prevent tooth decay (dental caries) and gum disease (gingivitis).[1] Salt and sodium bicarbonate (baking soda) are among materials that can be substituted for commercial toothpaste. Large amounts of swallowed toothpaste can be toxic.[2]

Usefulness

A 2016 systematic review indicates that using toothpaste when brushing the teeth has no impact on the level of plaque removal.[3]

{{Expand section|date=October 2018}}

Ingredients

In addition to 20%–42% water, toothpastes are derived from a variety of components, the three main ones being abrasives, fluoride, and detergents.

Abrasives

Abrasives constitute at least 50% of a typical toothpaste. These insoluble particles are designed to help remove plaque from the teeth. The removal of plaque and calculus prevents the accumulation of tartar and is widely claimed to help minimize cavities and periodontal disease, although the clinical significance of this benefit is debated[4]. Representative abrasives include particles of aluminum hydroxide (Al(OH)3), calcium carbonate (CaCO3), various calcium hydrogen phosphates, various silicas and zeolites, and hydroxyapatite (Ca5(PO4)3OH).

Abrasives, like the dental polishing agents used in dentists' offices, also cause a small amount of enamel erosion which is termed "polishing" action. Some brands contain powdered white mica, which acts as a mild abrasive, and also adds a cosmetically pleasing glittery shimmer to the paste. The polishing of teeth removes stains from tooth surfaces, but has not been shown to improve dental health over and above the effects of the removal of plaque and calculus.[5]

The abrasive effect of toothpaste is indicated by its RDA value. Too high RDA values are deleterious. Some dentists recommend toothpaste with an RDA value no higher than 50 for daily use.

Fluorides

{{main|Fluoride therapy}}Fluoride in various forms is the most popular active ingredient in toothpaste to prevent cavities. Fluoride is present in small amounts in plants, animals, and some natural water sources. The additional fluoride in toothpaste has beneficial effects on the formation of dental enamel and bones. Sodium fluoride (NaF) is the most common source of fluoride, but stannous fluoride (SnF2), olaflur (an organic salt of fluoride), and sodium monofluorophosphate (Na2PO3F) are also used. Stannous fluoride has been shown to be more effective than sodium fluoride in reducing the incidence of dental caries[6] and controlling gingivitis, but causes somewhat more surface stains.[7]

Much of the toothpaste sold in the United States has 1,000 to 1,100 parts per million fluoride.{{why|date=May 2018}} In European countries, such as the UK or Greece, the fluoride content is often higher;{{explain|date=May 2018}} a NaF content of 0.312% w/w (1,450 ppm fluoride) is common. All of these concentrations are likely to prevent tooth decay, according to a 2010 Cochrane review. Concentrations below 1,000 ppm are not likely to be preventive, and the preventive effect increases with concentration. Clinical trials support the use of high fluoride dentifrices,[8] as it was found to reduce the amount of plaque accumulated, decrease the number of mutans streptococci and lactobacilli and possibly promote calcium fluoride deposits to a higher degree than after the use of traditional fluoride containing dentifrices.[9] However, these effects must be balanced with the increased risk of harm at higher concentrations.[8]

Surfactants

Many, although not all, toothpastes contain sodium lauryl sulfate (SLS) or related surfactants (detergents). SLS is found in many other personal care products as well, such as shampoo, and is mainly a foaming agent, which enables uniform distribution of toothpaste, improving its cleansing power.[5]

Other components

Antibacterial agents

Triclosan, an antibacterial agent, is a common toothpaste ingredient in the United Kingdom. Triclosan or zinc chloride prevent gingivitis and, according to the American Dental Association, helps reduce tartar and bad breath.[1][10] A 2006 review of clinical research concluded there was evidence for the effectiveness of 0.30% triclosan in reducing plaque and gingivitis.[11] Another Cochrane review in 2013 has found that triclosan achieved a 22% reduction in plaque, and in gingivitis, a 48% reduction in bleeding gums. However, there was insufficient evidence to show a difference in fighting periodontitis and there was no evidence either of any harmful effects associated with the use of triclosan toothpastes for more than 3 years. The evidence relating to plaque and gingivitis was considered to be of moderate quality while for periodontitis was low quality.[12]

Flavorants

Toothpaste comes in a variety of colors and flavors, intended to encourage use of the product. The three most common flavorants are peppermint, spearmint, and wintergreen. Toothpaste flavored with peppermint-anise oil is popular in the Mediterranean region. These flavors are provided by the respective oils, e.g. peppermint oil.[5] More exotic flavors include Anethole anise, apricot, bubblegum, cinnamon, fennel, lavender, neem, ginger, vanilla, lemon, orange, and pine. Alternatively, unflavored toothpastes exist.

Remineralizers

Hydroxyapatite nanocrystals and a variety of calcium phosphates are included in formulations for remineralization,[13] i.e. the reformation of enamel.

Miscellaneous components

Agents are added to suppress the tendency of toothpaste to dry into a powder. Included are various sugar alcohols, such as glycerol, sorbitol, or xylitol, or related derivatives, such as 1,2-propylene glycol and polyethyleneglycol.[14] Strontium chloride or potassium nitrate is included in some toothpastes to reduce sensitivity. Two systemic meta-analysis reviews reported that arginine, and calcium sodium phosphosilicate - CSPS containing toothpastes are also effective in alleviating dentinal hypersensitivity respectively.[15][16] Another randomized clinical trial found superior effects when both formulas were combined together.[17]

Sodium polyphosphate is added to minimize the formation of tartar.{{citation needed|date=February 2018}} Other example to components in toothpastes is the Biotene, which has proved its efficiency in relieving the symptoms of dry mouth in people who suffer from xerostomia according to the results of two randomized clinical trials.[18][19]

Chlorohexidine mouthwash has been popular for its positive effect on controlling plaque and gingivitis,[20] however, a systemic review studied the effects of chlorohexidine toothpastes and found insufficient evidence to support its use, tooth surface discoloration was observed as a side effect upon using it, which is considered a negative side effect that can affect patients' compliance.[21]

Sodium hydroxide, also known as lye or caustic soda, is listed as an inactive ingredient in some toothpaste, for example Colgate Total.

Xylitol

Some studies have demonstrated that toothpastes with xylitol as an ingredient are more effective at preventing dental caries in permanent of children teeth than toothpastes containing fluoride alone. Furthermore, xylitol has not been found to cause any harmful effects. Further investigation into the efficacy of toothpastes containing this product is however required as the currently available studies are of low quality and therefore the results of such studies must be applied carefully.[22]

Safety

Fluoride

Fluoride-containing toothpaste can be acutely toxic if swallowed in large amounts,[23][24] however instances are exceedingly rare and result from prolonged and excessive use of toothpaste (i.e. several tubes per week).[25] Approximately 15 mg/kg body weight is the acute lethal dose, even though as small amount as 5 mg/kg may be fatal to some children.[26]

The risk of using fluoride is low enough that the use of full-strength toothpaste (1350–1500 ppm fluoride) is advised for all ages. However, smaller volumes are used for young children, for example, a smear of toothpaste until three years old.[24] A major concern of dental fluorosis is for children under 12 months ingesting excessive fluoride through toothpaste. Nausea and vomiting are also problems which might arise with topical fluoride ingestion.[26]

Diethylene glycol

The inclusion of sweet-tasting but toxic diethylene glycol in Chinese-made toothpaste led to a recall in 2007 involving multiple toothpaste brands in several nations.[27] The world outcry made Chinese officials ban the practice of using diethylene glycol in toothpaste.[28]

Triclosan

Reports have suggested triclosan, an active ingredient in many kinds of toothpastes, can combine with chlorine in tap water to form chloroform,[29] which the United States Environmental Protection Agency classifies as a probable human carcinogen. An animal study revealed the chemical might modify hormone regulation, and many other lab researches proved bacteria might be able to develop resistance to triclosan in a way which can help them to resist antibiotics also.[30]

Polyethylene glycol - PEG

PEG is a common ingredient in some of the formulas of toothpastes; it is a hydrophilic polymer that acts as a dispersant in toothpastes. Also, it is used in many cosmetic and pharmaceutical formulas, for example: ointments, osmotic laxatives, some of the non steroidal anti-inflammatory drugs, other medications and household products.[31] However, 37 cases of PEG hypersensitivity (delayed and immediate) to PEG-containing substances have been reported since 1977,[32] suggesting that they have unrecognized allergenic potential.[32]

Miscellaneous issues and debates

With the exception of toothpaste intended to be used on pets such as dogs and cats, and toothpaste used by astronauts, most toothpaste is not intended to be swallowed, and doing so may cause nausea or diarrhea. Tartar fighting toothpastes have been debated.[33] Case reports of plasma cell gingivitis have been reported with the use of herbal toothpaste containing cinnamon.[34] Sodium lauryl sulfate (SLS) has been proposed to increase the frequency of mouth ulcers in some people, as it can dry out the protective layer of oral tissues, causing the underlying tissues to become damaged.[35] In studies conducted by the university of Oslo on recurrent aphthous ulcers, it was found that SLS has a denaturing effect on the oral mucin layer, with high affinity for proteins, thereby increasing epithelial permeability.[36] In a double-blind cross-over study, a significantly higher frequency of aphthous ulcers was demonstrated when patients brushed with an SLS-containing versus a detergent-free toothpaste. Also patients with Oral Lichen Planus who avoided SLS-containing toothpaste benefited.[37][38]

Alteration of taste perception

After using toothpaste, orange juice and other juices have an unpleasant taste. Sodium lauryl sulfate alters taste perception. It can break down phospholipids that inhibit taste receptors for sweetness, giving food a bitter taste. In contrast, apples are known to taste more pleasant after using toothpaste.[39] Distinguishing between the hypotheses that the bitter taste of orange juice results from stannous fluoride or from sodium lauryl sulfate is still an unresolved issue and it is thought that the menthol added for flavor may also take part in the alteration of taste perception when binding to lingual cold receptors.{{citation needed|date=December 2014}}

Whitening toothpastes

Many toothpastes make whitening claims. Some of these toothpastes contain peroxide, the same ingredient found in tooth bleaching gels. The abrasive in these toothpastes, not the peroxide, removes the stains.[40] Whitening toothpaste cannot alter the natural color of teeth or reverse discoloration by penetrating surface stains or decay. To remove surface stains, whitening toothpaste may include abrasives to gently polish the teeth or additives such as sodium tripolyphosphate to break down or dissolve stains. When used twice a day, whitening toothpaste typically takes two to four weeks to make teeth appear whiter. Whitening toothpaste is generally safe for daily use, but excessive use might damage tooth enamel. Teeth whitening gels represent an alternative.[41][42] A recent systematic review in 2017 concluded that nearly all dentifrices that are specifically formulated for tooth whitening were shown to have a beneficial effect in reducing extrinsic stains, irrespective of whether or not a chemical discoloration agent was added.[43] However, the whitening process can permanently reduce the strength of the teeth, as the process scrapes away a protective outer layer of enamel.[44]

Herbal and natural toothpastes

Companies such as Tom's of Maine, among others, manufacture natural and herbal toothpastes and market them to consumers who wish to avoid the artificial ingredients commonly found in regular toothpastes. Many herbal toothpastes do not contain fluoride or sodium lauryl sulfate. The ingredients found in natural toothpastes vary widely but often include baking soda, aloe, eucalyptus oil, myrrh, plant extract (strawberry extract), and essential oils. A systemic review in 2014 found insufficient evidence to determine whether the aloe vera herbal dentifrice can reduce plaque or improve gingival health, as the randomized studies were found to be flawed with high risk of bias.[45]

According to a study by the Delhi Institute of Pharmaceutical Sciences and Research, many of the herbal toothpastes being sold in India were adulterated with nicotine.[46]

Charcoal has also been incorporated in toothpaste formulas; however, there is no evidence to determine its safety and effectiveness.[47]

Striped toothpaste

{{Refimprove section|date=September 2017}}

Striped toothpaste was invented by Leonard Marraffino in 1955. The patent (US patent {{US patent|2789731|2,789,731}}, issued 1957) was subsequently sold to Unilever, who marketed the novelty under the Stripe brand-name in the early 1960s. This was followed by the introduction of the Signal brand in Europe in 1965 (UK patent 813,514). Although Stripe was initially very successful, it never again achieved the 8% market share that it cornered during its second year.

Marraffino's design, which remains in use for single-color stripes, is simple. The main material, usually white, sits at the crimp end of the toothpaste tube and makes up most of its bulk. A thin pipe, through which that carrier material will flow, descends from the nozzle to it. The stripe-material (this was red in Stripe) fills the gap between the carrier material and the top of the tube. The two materials are not in separate compartments, however, they are sufficiently viscous that they will not mix. When pressure is applied to the toothpaste tube, the main material squeezes down the thin pipe to the nozzle. Simultaneously, the pressure applied to the main material causes pressure to be forwarded to the stripe material, which thereby issues out through small holes (in the side of the pipe) onto the main carrier material as it is passing those holes.

In 1990, Colgate-Palmolive was granted a patent (USPTO {{US patent|4969767|4,969,767}}) for two differently colored stripes. In this scheme, the inner pipe has a cone-shaped plastic guard around it, and about halfway up its length. Between the guard and the nozzle-end of the tube is a space for the material for one color, which issues out of holes in the pipe. On the other side of the guard is space for second stripe-material, which has its own set of holes.

Striped toothpaste should not be confused with layered toothpaste. Layered toothpaste requires a multi-chamber design (e.g. USPTO {{US patent|5020694|5,020,694}}), in which two or three layers extrude out of the nozzle. This scheme, like that of pump dispensers (USPTO {{US patent|4461403|4,461,403}}), is more complicated (and thus, more expensive to manufacture) than either the Marraffino design or the Colgate design.

History

Early toothpastes

Since 5000 BC, the Egyptians made a tooth powder, which consisted of powdered ashes of ox hooves, myrrh, powdered and burnt eggshells, and pumice. The Greeks, and then the Romans, improved the recipes by adding abrasives such as crushed bones and oyster shells.[48] In the 9th century, Iraqi musician and fashion designer Ziryab invented a type of toothpaste, which he popularized throughout Islamic Spain.[56] The exact ingredients of this toothpaste are unknown,[49] but it was reported to have been both "functional and pleasant to taste".[50] It is not known whether these early toothpastes were used alone, were to be rubbed onto the teeth with rags, or were to be used with early toothbrushes, such as neem-tree twigs and miswak. During Japan's Edo period, inventor Hiraga Gennai's Hika rakuyo (1769), contained advertisements for Sosekiko, a "toothpaste in a box."[51] Toothpastes or powders came into general use in the 19th century.

Tooth powder

Tooth powders for use with toothbrushes came into general use in the 19th century in Britain. Most were homemade, with chalk, pulverized brick, or salt as ingredients. An 1866 Home Encyclopedia recommended pulverized charcoal, and cautioned that many patented tooth powders that were commercially marketed did more harm than good.

Arm & Hammer marketed a baking soda-based toothpowder in the United States until approximately 2000, and Colgate currently markets toothpowder in India and other countries.

Modern toothpaste

An 18th-century American and British toothpaste recipe called for burned bread. Another formula around this time called for dragon's blood (a resin), cinnamon, and burned alum.[52]

By 1900, a paste made of hydrogen peroxide and baking soda was recommended for use with toothbrushes. Pre-mixed toothpastes were first marketed in the 19th century, but did not surpass the popularity of tooth-powder until World War I.

Together with Willoughby D. Miller, Newell Sill Jenkins developed a toothpaste and named it Kolynos, the first toothpaste containing disinfectants.[53] The name's origin is from Greek Kolyo nosos (κωλύω νόσος), meaning "disease prevention". Numerous attempts to produce the toothpaste by pharmacists in Europe have been uneconomic. After returning to the US, he continued experimenting with Harry Ward Foote (1875-1942), professor of chemistry at Sheffield Chemical Laboratory of Yale University.[54] After 17 years of development of Kolynos and clinical trials, Jenkins retired and transferred the production and distribution to his son Leonard A. Jenkins, who brought the first toothpaste tubes on the market on April 13, 1908. Within a few years the company expanded in North America, Latin America, Europe and the Far East. A branch operation opened in London in 1909. In 1937, Kolynos was produced in 22 countries and sold in 88 countries. Kolynos has been sold mainly in South America and in Hungary. Colgate-Palmolive took over the production of American Home Products in 1995 at a cost of one billion US dollars.[55]

Fluoride was first added to toothpastes in the 1890s. Tanagra, containing calcium fluoride as the active ingredient, was sold by Karl F. Toellner Company, of Bremen, Germany, based upon the early work of chemist Albert Deninger.[56] An analogous invention by Roy Cross, of Kansas City, Missouri, was initially criticized by the American Dental Association (ADA) in 1937. Fluoride toothpastes developed in the 1950s received the ADA's approval. To develop the first ADA-approved fluoride toothpaste, Procter & Gamble started a research program in the early 1940s. In 1950, Procter & Gamble developed a joint research project team headed by Dr. Joseph Muhler at Indiana University to study new toothpaste with fluoride. In 1955, Procter & Gamble's Crest launched its first clinically proven fluoride-containing toothpaste. On August 1, 1960, the ADA reported that "Crest has been shown to be an effective anticavity (decay preventative) dentifrice that can be of significant value when used in a conscientiously applied program of oral hygiene and regular professional care."

In 1980, the Japanese company, Sangi Co., Ltd., launched APADENT, the world's first remineralizing toothpaste to use a nano-form of hydroxyapatite, the main component of tooth enamel, rather than fluoride, to remineralize areas of mineral loss below the surface of tooth enamel (incipient caries lesions). After many years of laboratory experiments and field trials,[57] its hydroxyapatite ingredient was approved as an active anti-caries agent by the Japanese Ministry of Health in 1993, and given the name Medical Hydroxyapatite to distinguish it from other forms of hydroxyapatite used in toothpaste, such as dental abrasives.

In 2006, BioRepair appeared in Europe with the first European toothpaste containing synthetic hydroxylapatite as an alternative to fluoride for the remineralization and reparation of tooth enamel. The "biomimetic hydroxylapatite" is intended to protect the teeth by creating a new layer of synthetic enamel around the tooth instead of hardening the existing layer with fluoride that chemically changes it into fluorapatite.[58]

Toothpaste tubes

{{main|Tube (container)}}

In 1880, Doctor Washington Sheffield of New London, CT manufactured toothpaste into a collapsible tube, Dr. Sheffield's Creme Dentifrice. He had the idea after his son traveled to Paris and saw painters using paint from tubes. In York in 1896, Colgate & Company Dental Cream was packaged in collapsible tubes imitating Sheffield. The original collapsible toothpaste tubes were made of lead.[59][60]

See also

{{Portal|Dentistry}}
  • Dental floss
  • Mouthwash
  • Fluoride therapy
  • List of toothpaste brands

References

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33. ^{{cite web|url=http://www.toxictoothpaste.org/ |archive-url=https://web.archive.org/web/20120423145344/http://www.toxictoothpaste.org/ |archive-date=2012-04-23 |title=Tartar Fighting Toothpastes & Toxic Reactions|work=toxictoothpaste.org}}
34. ^{{cite journal | vauthors = Anil S | title = Plasma cell gingivitis among herbal toothpaste users: a report of three cases | journal = The Journal of Contemporary Dental Practice | volume = 8 | issue = 4 | pages = 60–6 | date = May 2007 | pmid = 17486188 | url = http://thejcdp.com/issue033/anil/anil.pdf | archive-url = https://web.archive.org/web/20090306045847/http://thejcdp.com/issue033/anil/anil.pdf | archive-date = 2009-03-06 }}
35. ^Canker Sores {{webarchive|url=https://web.archive.org/web/20060208030507/http://www.dentalgentlecare.com/cancer_sores_copy%281%29.htm |date=February 8, 2006 }}. Dentalgentlecare.com. Retrieved on April 4, 2013.
36. ^{{cite journal | vauthors = Herlofson BB, Barkvoll P | title = The effect of two toothpaste detergents on the frequency of recurrent aphthous ulcers | journal = Acta Odontologica Scandinavica | volume = 54 | issue = 3 | pages = 150–3 | date = June 1996 | pmid = 8811135 | doi = 10.3109/00016359609003515 }}
37. ^{{cite book|last1=Nikiforuk|first1=Gordon|title=Understanding dental caries. prevention: basic and clinical aspects|date=1985|publisher=Karger|location=Basel|isbn=978-3-8055-3905-0 | doi = 10.1159/000409915 | pages=87–112|chapter=5 Fluoride Dentifrices and Fluoride Rinses}}
38. ^{{cite journal | vauthors = Barkvoll P, Rølla G | title = Triclosan protects the skin against dermatitis caused by sodium lauryl sulphate exposure | journal = Journal of Clinical Periodontology | volume = 21 | issue = 10 | pages = 717–9 | date = November 1994 | pmid = 7852618 | doi = 10.1111/j.1600-051x.1994.tb00792.x }}
39. ^{{Cite journal|last=DeSimone A.|first=John|last2=Heck|first2=Gerard L.|last3=Bartoshuk|first3=Linda M. | name-list-format = vanc |title=Surface active taste modifiers: a comparison of the physical and psychophysical properties of gymnemic acid and sodium lauryl sulfate|journal=Chemical Senses|year=1980|volume=5|pages=317–330|doi=10.1093/chemse/5.4.317|issue=4}}
40. ^{{cite web | url = http://www.colgate.com/app/CP/US/EN/OC/Information/Articles/Cosmetic-Dentistry/Tooth-Whitening/Tooth-Whitening-Basics/article/Tooth-Whitening.cvsp#How_Its_Done | title = Tooth Whitening }}
41. ^{{cite web | author = Mayo Clinic Staff | url = http://www.mayoclinic.com/health/whitening-toothpaste/AN01818 | title = Whitening toothpaste: Does it actually whiten teeth? | work = Mayo Clinic | deadurl = bot: unknown | archiveurl = https://web.archive.org/web/20080503211651/http://www.mayoclinic.com/health/whitening-toothpaste/AN01818 | archivedate = May 3, 2008 | df = mdy-all }}
42. ^{{cite web|title=Best Toothpaste Brands|url=http://fashionguruji.in/best-toothpaste-in-india/|date=2018-02-18}}
43. ^{{cite journal | vauthors = Soeteman GD, Valkenburg C, Van der Weijden GA, Van Loveren C, Bakker E, Slot DE | title = Whitening dentifrice and tooth surface discoloration-a systematic review and meta-analysis | journal = International Journal of Dental Hygiene | volume = 16 | issue = 1 | pages = 24–35 | date = February 2018 | pmid = 28573755 | doi = 10.1111/idh.12289 }}
44. ^{{cite web|url=http://sciencefocus.com/qa/are-yellow-teeth-stronger|title=Are yellow teeth stronger?|work=sciencefocus.com}}
45. ^{{cite journal |doi=10.1111/odi.12113 |pmid=23607360 |title=Aloe vera herbal dentifrices for plaque and gingivitis control: A systematic review |journal=Oral Diseases |volume=20 |issue=3 |pages=254–67 |year=2014 |last1=Dhingra |first1=K }}
46. ^{{cite news|url=http://indiatoday.intoday.in/story/toothpastes-contain-cancer-causing-nicotine-study/1/150836.html|title=Toothpastes contain cancer causing nicotine, finds study|last=Chandra|first=Neetu | name-list-format = vanc |date=September 11, 2011|work=Mail Today|publisher=indiatoday.in|access-date=22 August 2014}}
47. ^{{cite journal | vauthors = Brooks JK, Bashirelahi N, Reynolds MA | title = Charcoal and charcoal-based dentifrices: A literature review | journal = Journal of the American Dental Association | volume = 148 | issue = 9 | pages = 661–670 | date = September 2017 | pmid = 28599961 | doi = 10.1016/j.adaj.2017.05.001 }}
48. ^The History of Toothpaste and Toothbrushes. Bbc.co.uk. Retrieved on April 4, 2013.
49. ^{{Cite journal|last=Lebling |first=Robert W. | name-list-format = vanc |title=Flight of the Blackbird|journal=Saudi Aramco World|date=July–August 2003|pages=24–33|url=http://www.islamicspain.tv/Arts-and-Science/flight_of_the_blackbird.htm|access-date=January 28, 2008}}
50. ^1 {{Cite book|last=Sertima|first=Ivan Van|authorlink=Ivan Van Sertima| name-list-format = vanc |year=1992|title=The Golden Age of the Moor|page=267|publisher=Transaction Publishers|isbn=978-1-56000-581-0}}
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52. ^{{cite web|url=http://www.toothpasteworld.com/history.htm |title=Other ingredients in toothpaste |access-date=December 23, 2007 |deadurl=bot: unknown |archive-url = https://web.archive.org/web/20071018032224/http://www.toothpasteworld.com/history.htm |archive-date=October 18, 2007 }}
53. ^{{cite book| first = Kerry | last = Segrave | name-list-format = vanc |title=America Brushes Up: The Use and Marketing of Toothpaste and Toothbrushes in the Twentieth Century|url=https://books.google.com/books?id=w9F5eTkLwcYC&pg=PA35|date=January 27, 2010|publisher=McFarland|isbn=978-0-7864-5684-0|pages=35}}
54. ^{{cite journal | vauthors = Johnson TB | title = Obituary on Harry Ward Foote | journal = Science | volume = 95 | issue = 2462 | pages = 241–2 | date = March 1942 | pmid = 17774149 | doi = 10.1126/science.95.2462.241 }}
55. ^{{cite web | url = http://collectingvintagecompacts.blogspot.de/2011/05/kolynos-toothpaste-and-nalgiri.html | title = Kolynos Toothpaste and Nalgiri Cosmetics – A curious blend of Greek and Hindu | work = Collecting Vintage Compacts }}
56. ^Early dental fluoride preparations (dentifrice, mouthwash, tablets, etc.). Fluoride-history.de. Retrieved on April 4, 2013.
57. ^{{cite journal | vauthors = Kani T, Kani M, Isozaki A, Shintani H, Ohashi T, Tokumoto T | title = Effect to Apatite-containing Dentifrices on Dental Caries in School Children | journal = Journal of Dental Health | volume = 39 | pages = 104–109 | year = 1989 | doi = 10.5834/jdh.39.104 }}
58. ^An enamel toothpaste that repairs teeth. BioRepair (January 18, 2013). Retrieved on April 4, 2013.
59. ^{{cite web | last = Schlosser | first = Jim | name-list-format = vanc | date = 20 December 2005 | url = http://blog.news-record.com/staff/architecture/2005/12/readers_have_po.shtml | title = Get the lead out didn't always mean for soldiers to speed up during World War II. It meant removing lead from toothpaste tubes to make bullets | work = Architecture Antiquity Artifacts | deadurl = yes | archiveurl = https://web.archive.org/web/20081013162246/http://blog.news-record.com/staff/architecture/2005/12/readers_have_po.shtml | archivedate = October 13, 2008 | df = mdy-all }}
60. ^{{cite web | first1 = Henry S. F. | last1 = Cooper | first2 = Brendan | last2 = Gill | name-list-format = vanc | url = http://www.newyorker.com/archive/1960/08/06/1960_08_06_020_TNY_CARDS_000262427 | title = The Talk of the Town: Collapsible | work = The New Yorker | date = 6 August 1960 }}

Further reading

  • {{Cite news |last=Hartman |first=Mitchell | name-list-format = vanc |date=March 16, 2018 |title=I've always wondered: how mint flavoring became associated with clean teeth |url=https://www.marketplace.org/2018/03/16/business/mouth-full-mint-cleaner-teeth-no-thanks |department=I've Always Wondered (story series) |work=Marketplace |publisher=American Public Media |access-date=March 16, 2018}} On the history of toothpaste.
  • {{Cite book |last=Duhigg |first=Charles | name-list-format = vanc |year=2012 |title=The Power of Habit: Why We Do What We Do in Life and Business |chapter=Chapter 2: The Craving Brain: How to Create New Habits: Part I |chapterurl=https://books.google.com/books?id=xQ1_z5_kj6sC&pg=PT52#v=twopage&q&f=false |location=New York |publisher=Random House |isbn=978-1400069286 |oclc=731918383}} On the history of the marketing of toothpaste.

External links

{{Commons category|Toothpaste}}
  • [https://web.archive.org/web/20110112232012/http://dentalplaque.wikispaces.com/Toothpaste Chemistry of Plaque Prevention with Toothpaste]
  • Fluoride toothpaste history
{{Dosage forms|state=collapsed}}{{Authority control}}

6 : Brands of toothpaste|Dentifrices|Dosage forms|Drug delivery devices|Oral hygiene|Teeth
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