| 词条 | Topogenic sequence |
| 释义 |
A topogenic sequence is a collective term used for a peptide sequence present at nascent proteins essential for their insertion and orienting in cellular membranes. The sequences are also used to translocate proteins across various intracellular membranes,[1] and ensure they are transported to the correct organelle after synthesis.[2] The position of the sequence may be at the end, e.g. N-terminal signal sequence, or in mid parts of the nascent protein, e.g. stop-transfer anchor sequences and signal-anchor sequences.[3] If the sequence is at the end of the polypeptide, it is cleaved off after entering the ER-lumen (via a translocon) by a signal peptidase, and subsequently degraded. As an example, the vast majority of all known complex plastid preproteins (an 'unactivated' protein) encoded in the nucleus possess a topogenic sequence.[2] See also
References1. ^{{cite journal|last=Robinson|first=A|date=1 September 1987|title=The role of topogenic sequences in the movement of proteins through membranes.|journal=Biochem. J.|volume=246|issue=2|pages=249–261|author2=Austen, B}} {{DEFAULTSORT:Topogenic Sequence}}{{Biochem-stub}}2. ^1 {{cite journal|last=Gould|first=Sven|date=June 2008|title=Plastid Evolution|journal=Annual Review of Plant Biology|volume=59|pages=491–517|doi=10.1146/annurev.arplant.59.032607.092915|pmid=18315522|author2=Waller, R|author3=McFadden, G}} 3. ^{{Cite book|title=Molecular Cell Biology|last=Lodish|first=Harvey|publisher=Macmillan Higher Education|year=2013|isbn=1-4292-3413-X|location=|pages=587–588}} 1 : Proteomics |
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