| 词条 | Tregalizumab |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 470612638 | type = mab | image = | alt = | mab_type = mab | source = zu | target = CD4 | tradename = | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_US = | pregnancy_category= | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = none | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 1207446-68-1 | ATC_prefix = none | ATC_suffix = | PubChem = | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | chemical_formula = | molecular_weight = | synonyms = BT-061 }}Tregalizumab is an immunomodulator.[1] It is also known as BT-061. Tregalizumab binds to domain 2 of CD4,[2] and activates Regulatory T cells (Tregs).[3] References1. ^{{cite journal|author=World Health Organization|year=2010|title=International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 104|url=http://www.who.int/medicines/publications/druginformation/innlists/Final_PL104.pdf|format=PDF|journal=WHO Drug Information|volume=24|issue=4}} {{monoclonals for immune system}}{{monoclonal-antibody-stub}}{{antineoplastic-drug-stub}}2. ^{{Cite journal|last=Helling B, König M, Dälken B, Engling A, Krömer W, Heim K, Wallmeier H, Haas J, Wildemann B, Fritz B, Jonuleit H, Kubach J, Dingermann T, Radeke HH, Osterroth F, Uherek C, Czeloth N, Schüttrumpf J|first=|date=April 2015|title=A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway|pmc=4407014|journal=Immunol Cell Biol|volume=93 |issue=4|pages=396–405}} 3. ^{{Cite journal|last=König M, Rharbaoui F, Aigner S, Dälken B, Schüttrumpf J|first=|date=Jan 2016|title=Tregalizumab - A Monoclonal Antibody to Target Regulatory T Cells.|pmc=4724712|journal=Frontiers in Immunology|volume=7|pages=}} 1 : Monoclonal antibodies |
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