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| Name = TRNA pseudouridine55 synthase
| EC_number = 5.4.99.25
| CAS_number = 430429-15-5
| IUBMB_EC_number = 5/4/99/25
| GO_code =
| image =
| width =
| caption =
}}TRNA pseudouridine55 synthase ({{EC number|5.4.99.25}}, TruB, aCbf5, Pus4, YNL292w (gene), Psi55 tRNA pseudouridine synthase, tRNA:Psi55-synthase, tRNA pseudouridine 55 synthase, tRNA:pseudouridine-55 synthase, Psi55 synthase, tRNA Psi55 synthase, tRNA:Psi55 synthase, tRNA-uridine55 uracil mutase, Pus10, tRNA-uridine54/55 uracil mutase) is an enzyme with systematic name tRNA-uridine55 uracil mutase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
tRNA uridine55tRNA pseudouridine55
Pseudouridine synthase TruB from Escherichia coli specifically modifies uridine55 in tRNA molecules.
References
1. ^{{cite journal | vauthors = Nurse K, Wrzesinski J, Bakin A, Lane BG, Ofengand J | title = Purification, cloning, and properties of the tRNA psi 55 synthase from Escherichia coli | journal = RNA | volume = 1 | issue = 1 | pages = 102–12 | date = March 1995 | pmid = 7489483 | pmc = 1369054 }}
2. ^{{cite journal | vauthors = Becker HF, Motorin Y, Planta RJ, Grosjean H | title = The yeast gene YNL292w encodes a pseudouridine synthase (Pus4) catalyzing the formation of psi55 in both mitochondrial and cytoplasmic tRNAs | journal = Nucleic Acids Research | volume = 25 | issue = 22 | pages = 4493–9 | date = November 1997 | pmid = 9358157 | pmc = 147073 | doi = 10.1093/nar/25.22.4493 }}
3. ^{{cite journal | vauthors = Pieńkowska J, Wrzesiński J, Szweykowska-Kulińska Z | title = A cell-free yellow lupin extract containing activities of pseudouridine 35 and 55 synthases | journal = Acta Biochimica Polonica | volume = 45 | issue = 3 | pages = 745–54 | year = 1998 | pmid = 9918501 }}
4. ^{{cite journal | vauthors = Chaudhuri BN, Chan S, Perry LJ, Yeates TO | title = Crystal structure of the apo forms of psi 55 tRNA pseudouridine synthase from Mycobacterium tuberculosis: a hinge at the base of the catalytic cleft | journal = The Journal of Biological Chemistry | volume = 279 | issue = 23 | pages = 24585–91 | date = June 2004 | pmid = 15028724 | doi = 10.1074/jbc.m401045200 }}
5. ^{{cite journal | vauthors = Hoang C, Hamilton CS, Mueller EG, Ferré-D'Amaré AR | title = Precursor complex structure of pseudouridine synthase TruB suggests coupling of active site perturbations to an RNA-sequestering peripheral protein domain | journal = Protein Science | volume = 14 | issue = 8 | pages = 2201–6 | date = August 2005 | pmid = 15987897 | pmc = 2279332 | doi = 10.1110/ps.051493605 }}
6. ^{{cite journal | vauthors = Gurha P, Gupta R | title = Archaeal Pus10 proteins can produce both pseudouridine 54 and 55 in tRNA | journal = RNA | volume = 14 | issue = 12 | pages = 2521–7 | date = December 2008 | pmid = 18952823 | pmc = 2590954 | doi = 10.1261/rna.1276508 }}
2. ^{{cite journal | vauthors = Becker HF, Motorin Y, Planta RJ, Grosjean H | title = The yeast gene YNL292w encodes a pseudouridine synthase (Pus4) catalyzing the formation of psi55 in both mitochondrial and cytoplasmic tRNAs | journal = Nucleic Acids Research | volume = 25 | issue = 22 | pages = 4493–9 | date = November 1997 | pmid = 9358157 | pmc = 147073 | doi = 10.1093/nar/25.22.4493 }}
3. ^{{cite journal | vauthors = Pieńkowska J, Wrzesiński J, Szweykowska-Kulińska Z | title = A cell-free yellow lupin extract containing activities of pseudouridine 35 and 55 synthases | journal = Acta Biochimica Polonica | volume = 45 | issue = 3 | pages = 745–54 | year = 1998 | pmid = 9918501 }}
4. ^{{cite journal | vauthors = Chaudhuri BN, Chan S, Perry LJ, Yeates TO | title = Crystal structure of the apo forms of psi 55 tRNA pseudouridine synthase from Mycobacterium tuberculosis: a hinge at the base of the catalytic cleft | journal = The Journal of Biological Chemistry | volume = 279 | issue = 23 | pages = 24585–91 | date = June 2004 | pmid = 15028724 | doi = 10.1074/jbc.m401045200 }}
5. ^{{cite journal | vauthors = Hoang C, Hamilton CS, Mueller EG, Ferré-D'Amaré AR | title = Precursor complex structure of pseudouridine synthase TruB suggests coupling of active site perturbations to an RNA-sequestering peripheral protein domain | journal = Protein Science | volume = 14 | issue = 8 | pages = 2201–6 | date = August 2005 | pmid = 15987897 | pmc = 2279332 | doi = 10.1110/ps.051493605 }}
6. ^{{cite journal | vauthors = Gurha P, Gupta R | title = Archaeal Pus10 proteins can produce both pseudouridine 54 and 55 in tRNA | journal = RNA | volume = 14 | issue = 12 | pages = 2521–7 | date = December 2008 | pmid = 18952823 | pmc = 2590954 | doi = 10.1261/rna.1276508 }}
External links
- {{MeshName|TRNA+pseudouridine55+synthase}}
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