| 词条 | Tropanserin |
| 释义 |
| IUPAC_name = [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3,5-dimethylbenzoate | image = Tropanserin.svg | CAS_number = 85181-40-4 | CAS_supplemental = {{CAS|85181-38-0}} (HCl) | ATC_prefix = None | ATC_suffix = | PubChem = 68600 | ChemSpiderID = 19969918 | C=17 | H=23 | N=1 | O=2 | molecular_weight = 273.370 g/mol | smiles = CN3[C@H]1CC[C@@H]3C[C@@H](C1)OC(=O)c2cc(C)cc(C)c2 | StdInChI = 1S/C17H23NO2/c1-11-6-12(2)8-13(7-11)17(19)20-16-9-14-4-5-15(10-16)18(14)3/h6-8,14-16H,4-5,9-10H2,1-3H3/t14-,15+,16+ | StdInChIKey = HDDNYFLPWFSBLN-ZSHCYNCHSA-N | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | pregnancy_category = | legal_status = | routes_of_administration = }}Tropanserin (INN; MDL-72,422) is a drug which acts as a potent and selective 5-HT3 receptor antagonist.[1] It was investigated in clinical trials for the treatment of migraine in the 1980s but was never marketed.[2] SynthesisTropanserin can be prepared by the reaction of tropine with 3,5-dimethylbenzoyl chloride. See also
References1. ^{{cite book | author1 = Frank D. King | author2 = Brian John Jones | author3 = Gareth J. Sanger | title = 5-Hydroxytryptamine-3 Receptor Antagonists | url = https://books.google.com/books?id=YSUAQFAga3oC&pg=PA244 | accessdate = 6 May 2012 | date = 22 October 1993 | publisher = CRC Press | isbn = 978-0-8493-5463-2 | page = 244}} {{Serotonergics}}{{nervous-system-drug-stub}}2. ^{{cite book | author = Denis M. Bailey | title = Annual Reports in Medicinal Chemistry | url = https://books.google.com/books?id=oJeTSJveeuAC&pg=PA44 | accessdate = 6 May 2012 | date = 1 August 1987 | publisher = Academic Press | isbn = 978-0-12-040522-0 | page = 44}} 3. ^J. R. Fozard and M. W. Gittos, {{US Patent|4,563,465}} (1986) via Chem. Abstr., 105:54,608j(1986) 3 : 5-HT3 antagonists|Benzoates|Tropanes |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。