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| Name = Tuberculosinol synthase
| EC_number = 3.1.7.8
| CAS_number =
| IUBMB_EC_number = 3/1/7/8
| GO_code =
| image = 4cmv.png
| width =
| caption = Crystal structure of tuberculosinol synthase. PDB entry {{PDBe|4cmv}}[1]
}}Tuberculosinol synthase ({{EC number|3.1.7.8}}, Rv3378c) is an enzyme with systematic name tuberculosinyl diphosphate diphosphohydrolase (tuberculosinol forming).[2][3] This enzyme catalyses the following chemical reaction
tuberculosinyl diphosphate + H2O[tuberculosinol] + diphosphate
This enzyme is present in Mycobacterium that cause tuberculosis.
References
1. ^{{cite journal | vauthors = Layre E, Lee HJ, Young DC, Martinot AJ, Buter J, Minnaard AJ, Annand JW, Fortune SM, Snider BB, Matsunaga I, Rubin EJ, Alber T, Moody DB | title = Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 111 | issue = 8 | pages = 2978–83 | date = February 2014 | pmid = 24516143 | doi = 10.1073/pnas.1315883111 | pmc = 3939896 }}
2. ^{{cite journal | vauthors = Nakano C, Ootsuka T, Takayama K, Mitsui T, Sato T, Hoshino T | title = Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R, S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome | journal = Bioscience, Biotechnology, and Biochemistry | volume = 75 | issue = 1 | pages = 75–81 | date = 2011 | pmid = 21228491 | doi = 10.1271/bbb.100570 }}
3. ^{{cite journal | vauthors = Hoshino T, Nakano C, Ootsuka T, Shinohara Y, Hara T | title = Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis | journal = Organic & Biomolecular Chemistry | volume = 9 | issue = 7 | pages = 2156–65 | date = April 2011 | pmid = 21290071 | doi = 10.1039/c0ob00884b }}
2. ^{{cite journal | vauthors = Nakano C, Ootsuka T, Takayama K, Mitsui T, Sato T, Hoshino T | title = Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R, S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome | journal = Bioscience, Biotechnology, and Biochemistry | volume = 75 | issue = 1 | pages = 75–81 | date = 2011 | pmid = 21228491 | doi = 10.1271/bbb.100570 }}
3. ^{{cite journal | vauthors = Hoshino T, Nakano C, Ootsuka T, Shinohara Y, Hara T | title = Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis | journal = Organic & Biomolecular Chemistry | volume = 9 | issue = 7 | pages = 2156–65 | date = April 2011 | pmid = 21290071 | doi = 10.1039/c0ob00884b }}
External links
- {{MeshName|Tuberculosinol+synthase}}
1 : EC 3.1.7
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