| 词条 | Tynorphin |
| 释义 |
| IUPAC_name = (2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoic acid | image = Tynorphin.svg | index_label = | index2_label = | CAS_number = | ATC_prefix = None | ATC_suffix = | PubChem = 9961318 | C=35 | H=46 | N=6 | O=7 | molecular_weight = 662.8 g/mol | smiles = CC(C)[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)O)N | ChemSpiderID = 8136925 | smiles2 = O=C(N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc3c2ccccc2[nH]c3)Cc4ccc(O)cc4)C(C)C)[C@@H](N)C(C)C | StdInChI = 1S/C35H46N6O7/c1-19(2)29(36)32(44)40-30(20(3)4)33(45)38-26(16-21-11-13-23(42)14-12-21)34(46)41-15-7-10-28(41)31(43)39-27(35(47)48)17-22-18-37-25-9-6-5-8-24(22)25/h5-6,8-9,11-14,18-20,26-30,37,42H,7,10,15-17,36H2,1-4H3,(H,38,45)(H,39,43)(H,40,44)(H,47,48)/t26-,27-,28-,29-,30-/m0/s1 | StdInChIKey = WLWBANYDSJWZBI-IIZANFQQSA-N | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | pregnancy_category = | legal_status = Non-regulated | routes_of_administration = }} Tynorphin is a synthetic opioid peptide which is a potent and competitive inhibitor of the enkephalinase class of enzymes which break down the endogenous enkephalin peptides.[1] It specifically inactivates dipeptidyl aminopeptidase III (DPP3) with very high efficacy, but also inhibits neutral endopeptidase (NEP), aminopeptidase N (APN), and angiotensin-converting enzyme (ACE) to a lesser extent.[1] It has a pentapeptide structure with the amino acid sequence Val-Val-Tyr-Pro-Trp. Tynorphin was discovered in an attempt to develop an enkephalinase inhibitor of greater potency than spinorphin.[1] See also
References1. ^1 2 {{cite journal |vauthors=Yamamoto Y, Hashimoto J, Shimamura M, Yamaguchi T, Hazato T | title = Characterization of tynorphin, a potent endogenous inhibitor of dipeptidyl peptidaseIII | journal = Peptides | volume = 21 | issue = 4 | pages = 503–8 |date=April 2000 | pmid = 10822105 | doi = 10.1016/S0196-9781(00)00174-1| url = http://linkinghub.elsevier.com/retrieve/pii/S0196978100001741}} {{Opioidergics}} 6 : Amines|Indoles|Opioids|Peptides|Propionic acids|Pyrrolidines |
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