| 词条 | Ungeremine |
| 释义 |
| ImageFile = Ungeremine.svg | ImageSize = 200px | IUPACName = 2-Hydroxy-4,5-dihydro[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-6-ium | OtherNames = |Section1={{Chembox Identifiers | CASNo = | PubChem = 159646 | ChemSpiderID = 140368 | SMILES = C1C[N+]2=CC3=CC4=C(C=C3C5=CC(=CC1=C52)O)OCO4 | InChI = 1/C16H11NO3/c18-11-3-9-1-2-17-7-10-4-14-15(20-8-19-14)6-12(10)13(5-11)16(9)17/h3-7H,1-2,8H2/p+1 | InChIKey = DFQOXFIPAAMFAU-IKLDFBCSAD | StdInChI = 1S/C16H11NO3/c18-11-3-9-1-2-17-7-10-4-14-15(20-8-19-14)6-12(10)13(5-11)16(9)17/h3-7H,1-2,8H2/p+1 | StdInChIKey = DFQOXFIPAAMFAU-UHFFFAOYSA-O |Section2={{Chembox Properties | C=16|H=12|N=1|O=3 | Formula_Charge=+1 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}Ungeremine is a betaine-type alkaloid isolated from Nerine bowdenii[1] and related plants such as Pancratium maritimum.[2] Pharmacologically, it is of interest as an acetylcholinesterase inhibitor and accordingly as possibly relevant to Alzheimer's disease.[3] It also has been investigated as a bactericide.[2] References1. ^{{cite journal | pmid=15516727 | year=2004 | author1=Rhee | first1=I. K. | title=Isolation of the acetylcholinesterase inhibitor ungeremine from Nerine bowdenii by preparative HPLC coupled on-line to a flow assay system | journal=Biological & Pharmaceutical Bulletin | volume=27 | issue=11 | pages=1804–9 | last2=Appels | first2=N | last3=Hofte | first3=B | last4=Karabatak | first4=B | last5=Erkelens | first5=C | last6=Stark | first6=L. M. | last7=Flippin | first7=L. A. | last8=Verpoorte | first8=R | doi=10.1248/bpb.27.1804}} {{Acetylcholine metabolism and transport modulators}}{{alkaloid-stub}}2. ^1 {{cite journal | doi = 10.1021/jf304586j| pmid = 23331165| title = Ungeremine and Its Hemisynthesized Analogues as Bactericides against Flavobacterium columnare| journal = Journal of Agricultural and Food Chemistry| volume = 61| issue = 6| pages = 1179| year = 2013| last1 = Schrader| first1 = Kevin K.| last2 = Avolio| first2 = Fabiana| last3 = Andolfi| first3 = Anna| last4 = Cimmino| first4 = Alessio| last5 = Evidente| first5 = Antonio}} 3. ^{{cite journal | doi = 10.2174/1570159X11311040004| pmid = 24381530| title = Natural AChE Inhibitors from Plants and their Contribution to Alzheimer's Disease Therapy| journal = Current Neuropharmacology| volume = 11| issue = 4| pages = 388| year = 2013| last1 = Murray| first1 = Ana| last2 = Faraoni| first2 = Maria| last3 = Castro| first3 = María| last4 = Alza| first4 = Natalia| last5 = Cavallaro| first5 = Valeria| pmc=3744903}} 3 : Acetylcholinesterase inhibitors|Alkaloids|Bactericides |
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