| 词条 | Vac7 |
| 释义 |
| Name = Vacuolar segregation protein 7 | image = | width = | caption = | Organism = S. cerevisiae S288c | TaxID = 559292 | Symbol = VAC7 | AltSymbols = | IUPHAR_id = | ATC_prefix = | ATC_suffix = | ATC_supplemental = | CAS_number = | CAS_supplemental = | DrugBank = | EntrezGene = 855673 | PDB = | RefSeqmRNA = NM_001182893 | RefSeqProtein = NP_014344 | UniProt = P53950 | ECnumber = | Chromosome = XIV | EntrezChromosome = NC_001146 | GenLoc_start = 525562 | GenLoc_end = 530109 }} Vacuolar segregation protein 7 is a protein that in yeast is encoded by the VAC7 gene. VAC7 is a component of the PI(3,5)P2 regulatory complex, composed of ATG18, FIG4, FAB1, VAC14 and VAC7. FunctionThe PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). VAC7 activates FAB1 kinase for example during hyperosmotic shock and can elevate levels of PtdIns(3,5)P2 in the absence of VAC14 and FIG4. VAC7 is directly involved in vacuolar membrane scission and is required for normal vacuole acidification, inheritance and morphology.[1][2][3][4][5] References1. ^UniProt {{UniProt|P53950}} {{protein-stub}}2. ^{{cite journal |vauthors=Bonangelino CJ, Catlett NL, Weisman LS | title = Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology | journal = Mol. Cell. Biol. | volume = 17 | issue = 12 | pages = 6847–58 |date=December 1997 | pmid = 9372916 | pmc = 232541 | doi = | url = | issn = }} 3. ^{{cite journal |vauthors=Gary JD, Sato TK, Stefan CJ, Bonangelino CJ, Weisman LS, Emr SD | title = Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member | journal = Mol. Biol. Cell | volume = 13 | issue = 4 | pages = 1238–51 |date=April 2002 | pmid = 11950935 | pmc = 102265 | doi = 10.1091/mbc.01-10-0498 | url = | issn = }} 4. ^{{cite journal |vauthors=Duex JE, Tang F, Weisman LS | title = The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover | journal = J. Cell Biol. | volume = 172 | issue = 5 | pages = 693–704 |date=February 2006 | pmid = 16492811 | pmc = 2063702 | doi = 10.1083/jcb.200512105 | url = | issn = }} 5. ^{{cite journal |vauthors=Jin N, Chow CY, Liu L, Zolov SN, Bronson R, Davisson M, Petersen JL, Zhang Y, Park S, Duex JE, Goldowitz D, Meisler MH, Weisman LS | title = VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse | journal = EMBO J. | volume = 27 | issue = 24 | pages = 3221–34 |date=December 2008 | pmid = 19037259 | pmc = 2600653 | doi = 10.1038/emboj.2008.248 | url = https://dash.harvard.edu/bitstream/handle/1/5311764/2600653.pdf?sequence=1| issn = }} 1 : Saccharomyces cerevisiae genes |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。