van Schalkwyk is an Afrikaans surname. Notable people with the surname include:

• Jaco van Schalkwyk (born 1979), South African rugby union player
• Marthinus van Schalkwyk (born 1959), South African politician
• Shadley van Schalkwyk (born 1988), South African cricketer
• Theunis van Schalkwyk (1929–2005), South African boxer

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