| 词条 | Triprolidine |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 470617213 | IUPAC_name = 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-yl- prop-1-enyl]pyridine | image = Triprolidine.svg | tradename = Actidil, Myidil, Actifed (in the latter combined with pseudoephedrine and either dextromethorphan or guaifenesin) | Drugs.com = {{drugs.com|monograph|triprolidine-hydrochloride}} | pregnancy_category = C (US) | legal_US = otc | routes_of_administration = Oral | bioavailability = 4% oral | protein_bound = 90% | metabolism = Hepatic (CYP2D6) | elimination_half-life = 4–6 hours | excretion = Renal | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 486-12-4 | ATC_prefix = R06 | ATC_suffix = AX07 | PubChem = 5282443 | IUPHAR_ligand = 1228 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB00427 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 4445597 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 2L8T9S52QM | KEGG_Ref = {{keggcite|changed|kegg}} | KEGG = D01782 | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 84116 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 855 | C=19 | H=22 | N=2 | molecular_weight = 278.391 g/mol | SMILES = n3c(\\C(=C\\CN1CCCC1)c2ccc(cc2)C)cccc3 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+ | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = CBEQULMOCCWAQT-WOJGMQOQSA-N | melting_point = 60 | solubility = 500 }}Triprolidine is an over-the-counter antihistamine with anticholinergic properties.[1] It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms.[2] As with many antihistamines, the most common side effect is drowsiness.[1] It was patented in 1948 and came into medical use in 1953.[3] References1. ^1 {{Cite journal | last1 = Goldsmith | first1 = P. | last2 = Dowd | first2 = P. M. | title = The new H1 antihistamines. Treatment of urticaria and other clinical problems | journal = Dermatologic clinics | volume = 11 | issue = 1 | pages = 87–95 | year = 1993 | pmid = 8094649}} {{Antihistamines}}{{Hallucinogens}}{{Histamine receptor modulators}}{{Muscarinic acetylcholine receptor modulators}}{{respiratory-system-drug-stub}}2. ^{{Cite journal | last1 = Williams | first1 = B. O. | last2 = Liao | first2 = S. H. | last3 = Lai | first3 = A. A. | last4 = Arnold | first4 = J. D. | last5 = Perkins | first5 = J. G. | last6 = Blum | first6 = M. R. | last7 = Findlay | first7 = J. W. | title = Bioavailability of pseudoephedrine and triprolidine from combination and single-ingredient products | journal = Clinical pharmacy | volume = 3 | issue = 6 | pages = 638–643 | year = 1984 | pmid = 6509877}} 3. ^{{cite book |last1=Fischer |first1=Jnos |last2=Ganellin |first2=C. Robin |title=Analogue-based Drug Discovery |date=2006 |publisher=John Wiley & Sons |isbn=9783527607495 |page=546 |url=https://books.google.ca/books?id=FjKfqkaKkAAC&pg=PA546 |language=en}} 5 : Alkene derivatives|H1 receptor antagonists|Muscarinic antagonists|Pyridines|Pyrrolidines |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。