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| Name = Very-long-chain 3-oxoacyl-CoA reductase
| EC_number = 1.1.1.330
| CAS_number =
| IUBMB_EC_number = 1/1/1/330
| GO_code =
| image =
| width =
| caption =
}}Very-long-chain 3-oxoacyl-CoA reductase ({{EC number|1.1.1.330}}, very-long-chain 3-ketoacyl-CoA reductase, very-long-chain beta-ketoacyl-CoA reductase, KCR (gene), IFA38 (gene)) is an enzyme with systematic name (3R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction
a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+a very-long-chain 3-oxoacyl-CoA + NADPH + H+
This microsomal complex extendins palmitoyl-CoA and stearoyl-CoA (and their modified forms) to very-long-chain acyl CoAs.
References
1. ^{{cite journal | title = A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal β-keto-reductase |author1 = Beaudoin, F. |author2 =Gable, K. |author3 =Sayanova, O. |author4 =Dunn, T. |author5 =Napier, J.A. |journal = J. Biol. Chem. |year = 2002 |volume = 277 |pages = 11481–11488 |pmid = 11792704 |doi=10.1074/jbc.M111441200 |issue=13}}
2. ^{{cite journal | title = The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase |author1 = Han, G. |author2 =Gable, K. |author3 =Kohlwein, S.D. |author4 =Beaudoin, F. |author5 =Napier, J.A. |author6 =Dunn, T.M. | journal = J. Biol. Chem. |year = 2002 |volume = 277 |pages = 35440–35449 |pmid = 12087109 |doi=10.1074/jbc.M205620200 |issue=38}}
3. ^{{cite journal | title = Functional characterization of the Arabidopsis β-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase |author1 = Beaudoin, F. |author2 =Wu, X. |author3 =Li, F. |author4 =Haslam, R.P. |author5 =Markham, J.E. |author6 =Zheng, H. |author7 =Napier, J.A. |author8 =Kunst, L. | journal = Plant Physiol. |year = 2009 |volume = 150 |pages = 1174–1191 |pmid = 19439572 |doi=10.1104/pp.109.137497 |issue=3 |pmc=2705042}}
2. ^{{cite journal | title = The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase |author1 = Han, G. |author2 =Gable, K. |author3 =Kohlwein, S.D. |author4 =Beaudoin, F. |author5 =Napier, J.A. |author6 =Dunn, T.M. | journal = J. Biol. Chem. |year = 2002 |volume = 277 |pages = 35440–35449 |pmid = 12087109 |doi=10.1074/jbc.M205620200 |issue=38}}
3. ^{{cite journal | title = Functional characterization of the Arabidopsis β-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase |author1 = Beaudoin, F. |author2 =Wu, X. |author3 =Li, F. |author4 =Haslam, R.P. |author5 =Markham, J.E. |author6 =Zheng, H. |author7 =Napier, J.A. |author8 =Kunst, L. | journal = Plant Physiol. |year = 2009 |volume = 150 |pages = 1174–1191 |pmid = 19439572 |doi=10.1104/pp.109.137497 |issue=3 |pmc=2705042}}
External links
- {{MeshName|Very-long-chain+3-oxoacyl-CoA+reductase}}
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