| 词条 | VHS protein domain |
| 释义 |
| Symbol = VHS | Name = VHS | image = PDB 1dvp EBI.jpg | width = | caption = crystal structure of the vhs and fyve tandem domains of hrs, a protein involved in membrane trafficking and signal transduction | Pfam = PF00790 | Pfam_clan = CL0009 | InterPro = IPR002014 | SMART = VHS | PROSITE = | MEROPS = | SCOP = 1elk | TCDB = | OPM family = | OPM protein = | CAZy = | CDD = }} In molecular biology, the VHS protein domain is approximately 140 residues long. Its name is an acronym derived from its occurrence in VPS-27, Hrs and STAM. It is a domain commonly found in the N-terminus of many proteins.[1] FunctionVHS domains thought to be very important in vesicular trafficking, in particular, aiding membrane targeting and cargo recognition role.[1] StructureResolution of the crystal structure of the VHS domain of Drosophila Hrs and human Tom1 revealed that it consists of eight helices arranged in a double-layer superhelix.[2] The existence of conserved patches of residues on the domain surface suggests that VHS domains may be involved in protein-protein recognition and docking. Overall, sequence similarity is low (approx 25%) amongst domain family members. ClassificationBased on regions surrounding the domain, VHS-proteins can be divided into 4 groups:[1]
References1. ^1 2 {{cite journal|vauthors=Lohi O, Poussu A, Mao Y, Quiocho F, Lehto VP | title=VHS domain -- a longshoreman of vesicle lines. | journal=FEBS Lett | year= 2002 | volume= 513 | issue= 1 | pages= 19–23 | pmid=11911875 | doi= 10.1016/s0014-5793(01)03287-2| pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11911875 }} {{InterPro content|IPR002014}}2. ^{{cite journal |vauthors=Mao Y, Nickitenko A, Duan X, Lloyd TE, Wu MN, Bellen H, Quiocho FA | title = Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction | journal = Cell | volume = 100 | issue = 4 | pages = 447–56 |date=February 2000 | pmid = 10693761 | doi = 10.1016/S0092-8674(00)80680-7| url = }} 3. ^{{cite journal |vauthors=Misra S, Beach BM, Hurley JH | title = Structure of the VHS domain of human Tom1 (target of myb 1): insights into interactions with proteins and membranes | journal = Biochemistry | volume = 39 | issue = 37 | pages = 11282–90 |date=September 2000 | pmid = 10985773 | doi = 10.1021/bi0013546| url = }} 2 : Protein families|Protein domains |
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