“Vincoline”的意思、由来-开放百科全书

词条

Vincoline

释义

References

{{Orphan|date=October 2013}}{{Chembox
| ImageFile = Vincoline.png
| ImageSize = 150px
| IUPACName = Methyl (2β,3β,5α,12β,19α,20S)-2-hydroxy-6,7-didehydro-3,20-epoxyaspidospermidine-3-carboxylate
| OtherNames =
|Section1={{Chembox Identifiers
| CASNo =
| PubChem = 3032566
| ChemSpiderID = 2297507
| SMILES = C[C@H]1[C@]23C[C@@](O1)([C@]4([C@@]5([C@H]2N(CC5)CC=C3)c6ccccc6N4)O)C(=O)OC
| InChI = 1/C21H24N2O4/c1-13-18-8-5-10-23-11-9-19(16(18)23)14-6-3-4-7-15(14)22-21(19,25)20(12-18,27-13)17(24)26-2/h3-8,13,16,22,25H,9-12H2,1-2H3/t13-,16-,18-,19+,20-,21-/m0/s1
| InChIKey = YOQNZWXFGROKGY-KVKBDHCBBE
| StdInChI = 1S/C21H24N2O4/c1-13-18-8-5-10-23-11-9-19(16(18)23)14-6-3-4-7-15(14)22-21(19,25)20(12-18,27-13)17(24)26-2/h3-8,13,16,22,25H,9-12H2,1-2H3/t13-,16-,18-,19+,20-,21-/m0/s1
| StdInChIKey = YOQNZWXFGROKGY-KVKBDHCBSA-N
|Section2={{Chembox Properties
| Formula = C₂₁H₂₄N₂O₄
| MolarMass = 368.426
| Appearance =
| Density =
| MeltingPt =
| BoilingPt =
| Solubility =
|Section3={{Chembox Hazards
| MainHazards =
| FlashPt =
| AutoignitionPt =
}}Vincoline is an alkaloid isolated from Catharanthus roseus.^[1] In a mouse model, it has been found to stimulate insulin secretion.^[2]

References

1. ^{{cite journal|pmid=4828700|year=1974|last1=Aynilian|first1=GH|last2=Weiss|first2=SG|last3=Cordell|first3=GA|last4=Abraham|first4=DJ|last5=Crane|first5=FA|last6=Farnsworth|first6=NR|title=Catharanthus alkaloids. XXIX. Isolation and structure elucidation of vincoline|volume=63|issue=4|pages=536–8|journal=Journal of Pharmaceutical Sciences|doi=10.1002/jps.2600630409}}
2. ^{{cite journal|pmid=24012527|year=2013|last1=Yao|first1=XG|last2=Chen|first2=F|last3=Li|first3=P|last4=Quan|first4=L|last5=Chen|first5=J|last6=Yu|first6=L|last7=Ding|first7=H|last8=Li|first8=C|last9=Chen|first9=L|last10=Gao|first10=Z|last11=Wan|first11=P|last12=Hu|first12=L|last13=Jiang|first13=H|last14=Shen|first14=X|title=Natural product vindoline stimulates insulin secretion and efficiently ameliorates glucose homeostasis in diabetic murine models|volume=150|issue=1|pages=285–97|doi=10.1016/j.jep.2013.08.043|journal=Journal of Ethnopharmacology}}

1 : Alkaloids

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