| 词条 | Vinod Scaria |
| 释义 |
|name = Dr. Vinod Scaria |caption = Dr. Vinod Scaria |birth_date = {{birth date and age|df=yes|1981|03|09}} |birth_place = Mbinga, Tanzania |residence = Delhi, India |citizenship =Indian |nationality = Indian |alma_mater = Calicut Medical College University of Pune |doctoral_advisor = Samir K. Brahmachari |website = {{URL|vinodscaria.rnabiology.org}} |field = Bioinformatics, Computational Biology |work_institution = Indraprastha Institute of Information Technology Delhi, Institute of Genomics and Integrative Biology, Academy of Scientific and Innovative Research | awards = {{Plainlist|
}} }} Dr. Vinod Scaria FRSB (born 9 March 1981) is an Indian researcher pioneering in Precision Medicine and Clinical Genomics in India. His previous research was in the area of micro-RNA and long noncoding RNA biology. He is best known for sequencing the first Indian genome.[1][2][3] He was also instrumental in the sequencing of The first Sri Lankan Genome, analysis of the first Malaysian Genome[4] and sequencing and analysis of the Wild-type strain of Zebrafish.[5] He was conferred the CSIR Young Scientist Award for biological sciences for developing computational tools to analyse genomic data, by the Prime Minister of India in September 2012.[6][7][8] He is presently a scientist at CSIR Institute of Genomics and Integrative Biology and an adjunct faculty at Indraprastha Institute of Information Technology, Delhi.[9] Early lifeVinod was born in, Tanzania in 1981. He did his schooling in Silver Hills Public School, Kozhikode, India. He studied for pre-degree course in St. Joseph's College, Devagiri and completed his undergraduate studies in medicine and surgery from Calicut Medical College with Gold Medals in Biochemistry and Physiology. He worked as a consultant for information technology at the Pain and Palliative Care society in Kozhikode. Later, he joined the CSIR Institute of Genomics and Integrative Biology, New Delhi, where he started his career as a researcher.[10] ResearchDr. Scaria started his research career at Calicut Medical College in the area of medical ethics and health information on Internet. After joining the CSIR Institute of Genomics and Integrative Biology in 2005, he switched to computational biology and genome informatics. His notable researches include the identification of human micro-RNA which can target HIV virus. In 2009 he and his colleagues at the Institute of Genomics and Integrative Biology announced the sequencing of the wild-type strain of zebrafish[11] and the sequencing of the first Human Genome from India. He also pioneered the use of social web for genome annotation, through mapping of TB genome.[12] Scaria and colleagues also discovered and designed enzyme silencers for mRNA, dubbed antagomiRzymes.His group also pioneered the use of social web, cloud computing and students for solving complex drug discovery problems for Neglected Diseases.[13] Dr Scaria has also been involved in popularising personal genomics through meragenome.com[14] and OpenPGx.[15] He has published numerous papers in international journals.[16] He is also the Editorial Board member of many reputed International Journals including PLOS ONE, PeerJ and Journal of Translational Medicine. He was also the member of senate of the Academy of Scientific and Innovative Research (AcSIR). He is a Kavli Frontiers of Science Fellow of the US National Academy of Sciences[17] and an elected Fellow of the Royal Society of Biology.[18] Precision Medicine and PharmacogenomicsHe specialises in genome-scale data for Precision Medicine with reference to Pharmacogenetics. He was one of the pioneers to be able to systematically analyse personal genome data to derive pharmacogenetic maps.[19] His research into population-specific genome scale data has provided one of the initial pharmacoepigenetic maps for Malaysia [20] and Qatar.[21] Genomics for Understanding Rare Diseases India Alliance Network (GUaRDIAN)Vinod Scaria has been pioneering the application of genomics to diagnose and solve rare genetic diseases in India, including discovering novel variants.[22] He, with his colleague Sridhar Sivasubbu co-founded a national network (GUaRDIAN)[23] of clinicians and researchers working on rare disease genomics. He also co-authored a handbook on exome sequencing and analysis for clinicians.[24] The GUaRDIAN consortium includes over 100 clinicians and researchers from over 25 medical and research centers making it one of the largest clinical genomics research networks in India working in the area of Rare Genetic Diseases.The research network has been quite successful in understanding variants associated with rare genetic diseases and be able to prevent them.[25] Genomics and other Omics Technologies to enable Medical Decisions (GOMED)Vinod Scaria has been involved in creating a unique programme along with his colleague Dr Mohammed Faruq which enable clinicians from across the country to tap into the rich expertise of CSIR Institute of Genomics and Integrative Biology in the area of genomics to enable fast and effective diagnosis of genetic diseases.[26] This programme today has been widely utilized by hospitals across the country.[27] Genomics of Arab and Middle Eastern PopulationsVinod Scaria has been pioneering the analysis of genomic data from Arab, Middle Eastern populations. His lab contributed to understanding the genetic landscape of Pharmacogenetics in Qatar.[28][29] He also pioneered the use of whole genome data to understand the genetic epidemiology of prevalent diseases in the region, including Familial Mediterranean Fever.[30] His lab also created one of the largest and comprehensive allele frequency resource for Arab populations.[31] This database al mena [32](alleles for Middle East and North Africa) provides information on over 26 million variants indexing a number of whole genome and exome datasets from the region. He is also pioneering the creation of a comprehensive resource for disease variants in the Arab population, in collaboration with multiple researchers from the region.[33] References1. ^{{cite news|last=C.G|first=Manoj|title=After human genome sequence, the scientist duo look ahead|url=http://www.indianexpress.com/news/After-human-genome-sequence--scientist-duo-looks-ahead/552214/|accessdate=10 February 2013|newspaper=The Indian Express|date=10 December 2009}} {{Scientific Research in Kerala |state=collapsed}}{{Authority control}}{{DEFAULTSORT:Scaria, Vinod}}2. ^{{cite news|last=G.N|first=Prasanth|title=Genome sequencing can be applied in clinical setting|url=http://articles.timesofindia.indiatimes.com/2009-12-10/india/28074037_1_sequencing-gene-mapping-igib|accessdate=10 February 2013|newspaper=Times of India|date=10 December 2009}} 3. ^{{cite news|last=Jingjing|first=Han|title=Scientists decode human genome for the first time in India|url=http://news.xinhuanet.com/english/2009-12/09/content_12616808.htm|accessdate=10 February 2013|newspaper=China News|date=9 December 2009}} 4. ^{{cite journal | last1 = Salleh | first1 = MZ | last2 = Teh | first2 = LK | last3 = Lee | first3 = LS | last4 = Ismet | first4 = RI | last5 = Patowary | first5 = A |display-authors=etal | year = 2013 | title = Systematic Pharmacogenomics Analysis of a Malay Whole Genome: Proof of Concept for Personalized Medicine | journal = PLoS ONE | volume = 8 | issue = 8| page = e71554 | doi = 10.1371/journal.pone.0071554 | pmid=24009664 | pmc=3751891}} 5. ^Patowary A, Purkanti R, Singh M, Chauhan R,Singh AR, Swarnkar M, Singh N, Pandey V, Torroja C, Clark MD, Kocher J, Clark KJ, Stemple DL, Klee EW, Ekker SC*, Scaria V, Sivasubbu S. A sequence-based variation map of zebrafish. Zebrafish. 2013 Mar;10(1):15–20 6. ^{{cite web|title=Young Scientist Awards|url=http://www.csir.res.in/external/heads/career/award/2012/YoungScientistAwards_2012.pdf|publisher=CSIR, India|accessdate=10 February 2013}} 7. ^{{cite news|title=PM gives away awards to scientists|url=http://www.mbctv.co.in/viewnews.php?news_id=13111|accessdate=10 February 2013|newspaper=MBCTV|date=26 September 2012}} 8. ^{{cite news|title=PM gives Swaroop Bhatnagar award to 11 scientists|url=http://news.outlookindia.com/items.aspx?artid=776370|accessdate=10 February 2013|newspaper=Outlook.com|date=26 September 2012}} 9. ^{{Cite web|url=https://www.iiitd.ac.in/people/faculty/adjunct-visiting|title=Visiting and Adjunct Faculty at IIIT-D}} 10. ^{{cite web|title=Vinod Scaria's profile|url=http://igib.res.in/?q=node/47|publisher=Institute of Genomics and Integrative Biology|accessdate=10 February 2013}} 11. ^{{cite web|title=Genome of Zebrafish Wild-type Strain(ASWT)|url=http://zebrafish.igib.in/aswt-genome|publisher=IGIB.in|accessdate=17 April 2013}} 12. ^{{cite news|title=Detailed map of TB genome to help treatment|url=http://www.hindustantimes.com/world-news/Americas/Detailed-map-of-TB-genome-to-help-treatment/Article1-530102.aspx|accessdate=10 February 2013|newspaper=The Hindustan Times|date=12 April 2010}} 13. ^{{cite web|title=Crowd Computing for Cheminformatics|url=http://vinodscaria.rnabiology.org/crowd-computing-for-cheminformatics-2013|publisher=RNA Biology|accessdate=17 February 2013|archive-url=https://web.archive.org/web/20130112200535/http://vinodscaria.rnabiology.org/crowd-computing-for-cheminformatics-2013|archive-date=12 January 2013|dead-url=yes|df=dmy-all}} 14. ^{{cite web|title=meragenome.com : Personal Genomics for All|url=http://www.meragenome.com|accessdate=10 April 2013}} 15. ^{{cite web|title=OpenPGx|url=http://www.openpgx.org|accessdate=10 April 2013}} 16. ^{{cite web|title=Publications of Vinod Scaria|url=http://vinodscaria.rnabiology.org/publications|publisher=RNA Biology|accessdate=10 February 2013}} 17. ^{{cite web|url=http://www.nasonline.org/programs/kavli-frontiers-of-science/frontiers-alumni/alumni-directory/vinod-scaria.html}} 18. ^{{cite web|url=http://vinodscaria.rnabiology.org/VinodScaria}} 19. ^{{cite journal|last1=Salleh|first1=Mohammed Zaki|title=Systematic pharmacogenomics analysis of a Malay whole genome: proof of concept for personalized medicine.|journal=PLOS ONE|volume=8|issue=8|page=e71554|doi=10.1371/journal.pone.0071554|pmid=24009664|pmc=3751891}} 20. ^{{cite web|title=Why Indians, SE Asian Malays respond differently to some drugs|url=http://www.thehindu.com/sci-tech/science/why-indians-se-asian-malays-respond-differently-to-some-drugs/article8718323.ece|accessdate=10 October 2016}} 21. ^{{cite web|title=Qatar exome study: An advancement in precision medicine|url=http://www.natureasia.com/en/nmiddleeast/article/10.1038/nmiddleeast.2016.137|accessdate=10 October 2016}} 22. ^{{cite web|title=Exome sequencing reveals a novel mutation, p.L325H, in the KRT5 gene associated with autosomal dominant Epidermolysis Bullosa Simplex Koebner type in a large family from western India|url=http://www.nature.com/articles/hgv20147 |publisher=Human Genome Variation|accessdate=17 Dec 2014}} 23. ^{{cite web|title=Genomics for Understanding Rare Diseases India Alliance Network|url=http://guardian.meragenome.com|accessdate=25 December 2014}} 24. ^{{cite book|last1=Scaria|first1=Vinod|last2=Sivasubbu|first2=Sridhar|title=Exome Sequencing, Analysis and Interpretation : Handbook for Clinicians|publisher=Research In Genomics|location=India|pages=126|url=https://books.google.com/books/about?id=TNCZBgAAQBAJ|accessdate=5 April 2015}} 25. ^{{cite news|last1=Isalkar|first1=Umesh|title=Research on genes rules out ailment in youngest sibling|url=http://timesofindia.indiatimes.com/city/pune/Research-on-genes-rules-out-ailment-in-youngest-sibling/articleshow/54707469.cms|accessdate=10 October 2016|agency=TNN|publisher=The Times of India|date=6 October 2016}} 26. ^{{Cite web|url=http://gomed.igib.in|title=Genomics and other omics technologies to enable Medical Decisions}} 27. ^{{Cite web|url=http://gomed.igib.in/statistics|title=Referral statistics of GOMED}} 28. ^{{cite journal|last1=Sivadas|first1=Ambily|last2=Sharma|first2=Parul|last3=Scaria|first3=Vinod|title=Landscape of warfarin and clopidogrel pharmacogenetic variants in Qatari population from whole exome datasets|journal=Pharmacogenomics|date=November 2016|volume=17|issue=17|pages=1891–1901|doi=10.2217/pgs-2016-0130}} 29. ^{{cite journal|last1=Sivadas|first1=Ambily|last2=Scaria|first2=Vinod|title=Pharmacogenomic survey of Qatari populations using whole-genome and exome sequences|journal=The Pharmacogenomics Journal|doi=10.1038/s41397-018-0022-8|url=https://www.nature.com/articles/s41397-018-0022-8|accessdate=7 May 2018}} 30. ^{{cite journal|last1=Koshy|first1=Remya|last2=Sivadas|first2=Ambily|last3=Scaria|first3=Vinod|title=Genetic epidemiology of Familial Mediterranean Fever through integrative analysis of whole genome and exome sequences from Middle East and North Africa|journal=Clinical Genetics|date=9 June 2017|doi=10.1111/cge.13070}} 31. ^{{cite journal|last1=Koshy|first1=Remya|last2=Ranawat|first2=Anop|last3=Scaria|first3=Vinod|title=al mena: a comprehensive resource of human genetic variants integrating genomes and exomes from Arab, Middle Eastern and North African populations|journal=Journal of Human Genetics|date=22 June 2017|doi=10.1038/jhg.2017.67}} 32. ^{{cite web|title=al mena|url=http://clingen.igib.res.in/almena/|website=clingen.igib.res.in}} 33. ^{{cite web|title=Comprehensive resource of genetic variants associated with diseases in Arabs - Vinod Scaria MBBS, PhD|url=http://vinodscaria.rnabiology.org/arab-and-middle-eastern-population-genomics/genetic-disease-variants-in-arabs|website=vinodscaria.rnabiology.org}} 8 : Indian biochemists|Living people|1981 births|Scientists from Kozhikode|Indian medical researchers|Indian biotechnologists|Savitribai Phule Pune University alumni|Fellows of the Royal Society of Biology |
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