词条 | WDR90 |
释义 |
GeneIn the human genome, WDR90 spans from base pairs 649363 to 667833, and has an mRNA sequence that is 5,250 nucleotides in length. This gene consists of 41 exons and encodes for a 1,750 amino acid protein in humans. LocusThis human gene is located in the positive DNA strand on chromosome 16 at the position 16p13.3.[1] Flanking sequences on the positive strand include FAM195A and RHOT2.[3] AliasesAliases for WDR90 include: C16orf15, C16orf16, C16orf17, C16orf18, C16orf19, and KIAA1924.[1] HomologyParalogsOne human paralog for WDR90 has been found. This paralog is known as WDR16. According to UniProtKB/Swiss-Prot, WDR16 may play an essential role in growth or survival of hepatocellular carcinoma. This protein in humans if 620 amino acids long.[6][7] OrthologsOrthologs for protein WDR90 are found conserved all the way back to single invertebrates.[8] There were three conserved domains across mammals, DUF667 (location 3-124), and two WD40 repeats (locations 697-991, and 1155-1549).[3] ProteinPrimary sequenceHuman protein WDR90 is 287.7 kDa, with an isoelectric point of 6.584. There is a domain of unknown function called DUF667 that is conserved across its 30 predicted isoforms.[9] Post-translational modificationsWDR90 is predicted to be a heavily phosphorylated protein.[10] Domains and motifsThere are three domains that repeat throughout the human sequence.[11] Secondary StructureThe de novo protein structure of WDR90 in humans is predicted to possess beta sheets, beta turns, and random coils.[12] Tertiary and Quaternary StructureThe human protein WDR90 adopts a 7-bladed beta propeller that is indicative of the WD40 repeat family. This structure was predicted with 100% confidence by the structure predicting program Phyre2. Interacting ProteinsThe most notable proteins that interact with human WDR90 are predicted to be UTY, KDM6B, SETD1B, and ASH2L.[13] These proteins are primarily found as histone modifiers. Transcription FactorsThe promoter for WDR90 in humans has been predicted to have domains for the transcription factors: ARNT, AP-1, MYB, and Cis2His2.[14] ExpressionExpression levels of human WDR90 appear to be relatively constituent in low levels, with its highest levels in the lymph nodes and thymus.[15][16] The expression of WDR90 in development is the highest in blastocyst and fetal stages. Expression is notably absent from the neonatal and infant stages, then comes back during juvenile and persists through adulthood.[16] FunctionThe function of WDR90 in humans in not well known. Given its broad expression in many tissues, its ties to the protein superfamily WD40 domain-containing proteins, and the known protein interactions, it could play a role in histone modifications, vesicular transport, or transcription regulation.[13][15][16] References1. ^1 2 {{Cite web|title = WDR90 Gene - GeneCards {{!}} WDR90 Protein {{!}} WDR90 Antibody|url = https://www.genecards.org/cgi-bin/carddisp.pl?gene=WDR90|website = www.genecards.org|accessdate = 2015-05-06|first = GeneCards|last = Database}} 2. ^Volker Brendel, Department of Mathematics, Stanford University, Stanford CA 94305, U.S.A., modified; any errors are due to the modification. http://workbench.sdsc.edu/ 3. ^1 2 https://www.ncbi.nlm.nih.gov/gene/197335 4. ^{{Cite web|title = NCBI - WWW Error Blocked Diagnostic|url = https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?UGID=902650&TAXID=9606&SEARCH=WDR90|website = www.ncbi.nlm.nih.gov|accessdate = 2015-04-30}} 5. ^{{Cite journal|title = WD40 proteins propel cellular networks|journal = Trends in Biochemical Sciences|date = Oct 2010|issn = 0968-0004|pmid = 20451393|pages = 565–574|volume = 35|issue = 10|doi = 10.1016/j.tibs.2010.04.003|first = Christian U.|last = Stirnimann|first2 = Evangelia|last2 = Petsalaki|first3 = Robert B.|last3 = Russell|first4 = Christoph W.|last4 = Müller}} 6. ^{{Cite web|title = WDR16 Gene - GeneCards {{!}} WDR16 Protein {{!}} WDR16 Antibody|url = https://www.genecards.org/cgi-bin/carddisp.pl?gene=WDR16&search=f93edcafc7b414b0d4fe4d1911579457|website = www.genecards.org|accessdate = 2015-05-06|first = GeneCards|last = Database}} 7. ^{{Cite web|title = ExPASy: SIB Bioinformatics Resource Portal - Categories|url = http://www.expasy.org/proteomics|website = www.expasy.org|accessdate = 2015-05-06}} 8. ^{{Cite web|url = http://seqtool.sdsc.edu/CGI/BW.cgi#!|title = CLUSTALWPROF|date = |accessdate = |website = Biology Workbench|publisher = SDSC|last = |first = }}{{Dead link|date=July 2018 |bot=InternetArchiveBot |fix-attempted=yes }} 9. ^{{Cite web|url = http://seqtool.sdsc.edu/CGI/BW.cgi#!|title = Biology WorkBench|date = Statistical Analysis of PS|accessdate = |website = |publisher = Volker Brendel, Department of Mathematics, Stanford University, Stanford CA 94305, U.S.A., modified; any errors are due to the modification.|last = |first = }}{{Dead link|date=July 2018 |bot=InternetArchiveBot |fix-attempted=yes }} 10. ^{{Cite web|title = NetPhos 2.0 Server|url = http://www.cbs.dtu.dk/services/NetPhos/|website = www.cbs.dtu.dk|accessdate = 2015-05-07}} 11. ^{{Cite web|title = Ensembl genome browser 79: Homo sapiens - Domains & features - Transcript: WDR90-002 (ENST00000293879)|url = http://useast.ensembl.org/Homo_sapiens/Transcript/Domains?db=core;g=ENSG00000161996;r=16:649311-667833;t=ENST00000293879|website = useast.ensembl.org|accessdate = 2015-05-06}} 12. ^{{Cite web|title = NPS@ : SOPMA secondary structure prediction|url = https://npsa-prabi.ibcp.fr/cgi-bin/npsa_automat.pl?page=npsa_sopma.html|website = npsa-prabi.ibcp.fr|accessdate = 2015-05-07|first = Institut|last = UCBL}} 13. ^1 {{Cite web|title = STRING: functional protein association networks|url = http://string-db.org/newstring_cgi/show_input_page.pl|website = string-db.org|accessdate = 2015-05-07}} 14. ^{{Cite web|title = Genomatix: Retrieve and analyze promoters: Query Input|url = https://www.genomatix.de/cgi-bin//c2p/c2p.pl?s=33e03e12197d2119c8cf1b5e0dc2b575;TASK=c2p;SHOW=WDR90.html|website = www.genomatix.de|accessdate = 2015-05-07}} 15. ^1 {{Cite web|title = NCBI - WWW Error Blocked Diagnostic|url = https://www.ncbi.nlm.nih.gov/geoprofiles|website = www.ncbi.nlm.nih.gov|accessdate = 2015-05-07}} 16. ^1 2 {{Cite web|title = NCBI - WWW Error Blocked Diagnostic|url = https://www.ncbi.nlm.nih.gov/UniGene/ESTProfileViewer.cgi?uglist=Hs.511903|website = www.ncbi.nlm.nih.gov|accessdate = 2015-05-07}} Suggested Reading
1 : Human proteins |
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