WESI may refer to:

• WESI-LP, a low-power radio station (92.3 FM) licensed to serve Sugarhill, Georgia, United States
• WGHL, a radio station (105.1 FM) licensed to serve Shepherdsville, Kentucky, United States, which held the call sign WESI from 2013 to 2014
• WZFC, a radio station (104.9 FM) licensed to serve Strasburg, Virginia, United States, which held the call sign WESI from 1986 to 1992

• John Villiers Shelley
• John Vincent (American football)
• John Vincent Barry
• John Vincent (bishop)
• John Vincent Cane
• John Vincent (composer)
• John Vincent (disambiguation)
• John Vincent (football coach)
• John Vincent (lawyer)
• John Vincent (New York)
• John Vinnicum Morse
• John VI of Aumont
• John VI of Harcourt
• John VI of Russia
• John VI of Vendome
• John VI of Vendôme
• John VI, Prince of Anhalt-Zerbst
• John Virgil Singleton
• John Virgil Singleton Jr.
• John Virgil Singleton, Jr.
• John Virginius Bennes
• John Vistic
• John Vitale
• John Vitale(Mobster)
• John Vitale (mobster)