Wilshire is an English surname. Notable people with the surname include:

• Brian Wilshire, Australian radio talkback host
• Bruce Wilshire, American philosopher and professor at Rutgers University
• David Wilshire, British politician and Parliament member
• Henry Austin Wilshire, Australian architect
• Henry Gaylord Wilshire, American land developer, namesake of Wilshire Boulevard in Los Angeles, California
• Jack Wilshire, English footballer
• William Wallace Wilshire, American politician

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