| 词条 | Y-27632 |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 444248572 | ImageFile = Y-27632.svg | ImageSize = 200px | ImageAlt = | IUPACName = (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide | OtherNames = |Section1={{Chembox Identifiers | IUPHAR_ligand = 5290 | CASNo = 146986-50-7 | CASNo_Ref = {{cascite|correct|CAS}} | PubChem = 448042 | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 75393 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 2218937 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB08756 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = IYOZTVGMEWJPKR-IJLUTSLNSA-N | SMILES = O=C([C@H]1CC[C@@]([C@H](N)C)([H])CC1)NC2=CC=NC=C2 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 20016532 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1 | InChI = 1/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1 | InChIKey = IYOZTVGMEWJPKR-IJLUTSLNBP }} |Section2={{Chembox Properties | C=14 | H=21 | N=3 | O=1 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = }} |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} }}Y-27632 is a biochemical tool used in the study of the rho-associated protein kinase (ROCK) signaling pathways.[1] Y-27632 selectively inhibits p160ROCK.[2] It has been studied for its effects on corneal endothelial cells (CECs) [3] and cardiac stem cells (CSCs).[4] References1. ^{{cite journal | author = Uehata, Masayoshi | title = Y-27632. Selective probe of ROCK/Rho-kinase | journal = Jikken Igaku | year = 1999 | volume = 17 | issue = 7 | pages = 850–855}} {{heterocyclic-stub}}2. ^{{cite journal | pmid = 9353125 | year = 1997 | last1 = Uehata | first1 = M | last2 = Ishizaki | first2 = T | last3 = Satoh | first3 = H | last4 = Ono | first4 = T | last5 = Kawahara | first5 = T | last6 = Morishita | first6 = T | last7 = Tamakawa | first7 = H | last8 = Yamagami | first8 = K | last9 = Inui | first9 = J | last10 = Inui | first10 = Jun | last11 = Maekawa | first11 = Midori | title = Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension | volume = 389 | issue = 6654 | pages = 990–4 | doi = 10.1038/40187 | journal = Nature| display-authors = 8 }} 3. ^{{Cite journal|last=Peh|first=Gary S. L.|last2=Adnan|first2=Khadijah|last3=George|first3=Benjamin L.|last4=Ang|first4=Heng-Pei|last5=Seah|first5=Xin-Yi|last6=Tan|first6=Donald T.|last7=Mehta|first7=Jodhbir S.|date=2015-03-16|title=The effects of Rho-associated kinase inhibitor Y-27632 on primary human corneal endothelial cells propagated using a dual media approach|journal=Scientific Reports|volume=5|doi=10.1038/srep09167|issn=2045-2322|pmc=4387913|pmid=25823914}} 4. ^{{Cite journal|last=Kan|first=Lijuan|last2=Smith|first2=Aubrie|last3=Chen|first3=Miao|last4=Ledford|first4=Benjamin T.|last5=Fan|first5=Huimin|last6=Liu|first6=Zhongmin|last7=He|first7=Jia-Qiang|date=2015-12-08|title=Rho-Associated Kinase Inhibitor (Y-27632) Attenuates Doxorubicin-Induced Apoptosis of Human Cardiac Stem Cells|url=http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144513|journal=PLOS ONE|volume=10|issue=12|pages=e0144513|doi=10.1371/journal.pone.0144513|issn=1932-6203|pmc=4672899|pmid=26645568}} 2 : Pyridines|Protein kinase inhibitors |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。