| 词条 | YceI protein domain |
| 释义 |
| Symbol = YceI | Name = YceI | image = PDB 1wub EBI.jpg | width = | caption = Crystal structure of the polyisoprenoid-binding protein, TT1927B, from Thermus thermophilus hb8 | Pfam = PF04264 | Pfam_clan = | InterPro = IPR007372 | SMART = | PROSITE = | MEROPS = | SCOP = 1uf6 | TCDB = | OPM family = 101 | OPM protein = 3hpe | CAZy = | CDD = }} In molecular biology, Yce-I protein domain is a putative periplasmic protein. This entry represents the lipid-binding protein YceI from Escherichia coli [1] and the polyisoprenoid-binding protein TTHA0802 from Thermus thermophilus.[2] Its role is to help aid the biosynthesis of isoprenoid, an important molecule found in all living organisms. StructureBoth of these proteins share a common domain with an 8-stranded beta-barrel fold. This resembles the lipocalin fold, although no sequence homology exists with lipocalins. In TTHA0802, the protein binds the polyisoprenoid chain within the pore of the barrel via hydrophobic interactions.[2] Sequence homologues of this core structure are present in a wide range of bacteria and archaea. FunctionThe crystal structures suggests that this family of proteins plays an important role in isoprenoid quinone metabolism or in transport or storage. In both cases, the protein is a homodimer, each monomer being characterized by a lipocalin fold.[2] References1. ^{{cite journal |vauthors=Stancik LM, Stancik DM, Schmidt B, Barnhart DM, Yoncheva YN, Slonczewski JL | title = pH-dependent expression of periplasmic proteins and amino acid catabolism in Escherichia coli | journal = J. Bacteriol. | volume = 184 | issue = 15 | pages = 4246–58 |date=August 2002 | pmid = 12107143 | pmc = 135203 | doi = 10.1128/jb.184.15.4246-4258.2002| url = }} {{InterPro content|IPR007372}}2. ^1 2 {{cite journal |vauthors=Handa N, Terada T, Doi-Katayama Y, Hirota H, Tame JR, Park SY, Kuramitsu S, Shirouzu M, Yokoyama S | title = Crystal structure of a novel polyisoprenoid-binding protein from Thermus thermophilus HB8 | journal = Protein Sci. | volume = 14 | issue = 4 | pages = 1004–10 |date=April 2005 | pmid = 15741337 | pmc = 2253440 | doi = 10.1110/ps.041183305 | url = }} 2 : Protein domains|Protein families |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。