| 词条 | Yoshiki Sasai |
| 释义 |
| name = Yoshiki Sasai | image = Yoshiki Sasai, circa 2012.jpg | imagesize = | alt = | caption = Yoshiki Sasai, circa 2012 | birth_date = 5 March 1962 | birth_place = Hyogo, Japan | death_date = {{death date and age|2014|8|5|1962|1|1|df=y}} | death_place = Kobe, Hyogo, Japan | nationality = Japanese | fields = Biology | workplaces = RIKEN | alma_mater = Kyoto University | doctoral_advisor = Shigetada Nakanishi | doctoral_students = | known_for = | awards = Osaka Science Prize Inoue Prize for Science | website = {{URL|https://web.archive.org/web/20140309173143/http://www.cdb.riken.jp/sasai/}} }}{{nihongo|Yoshiki Sasai|笹井 芳樹|Sasai Yoshiki|5 March 1962 – 5 August 2014}} was a stem cell biologist. He developed methods to guide human embryonic stem cells (hESCs) into forming brain cortex, eyes, and other organs in tissue culture. Sasai was one of the founding leaders of the RIKEN Center for Developmental Biology (CDB) in Kobe, a premier research institute for biology in Japan and Director of the Laboratory for Organogenesis and Neurogenesis at the research institute RIKEN. Sasai was best known for developing new methods to grow stem cells into organ-like structures.[1][2][3][4][5][6][7][8][9] In 2012, Sasai became the first stem cell researcher to grow an optic cup from human cells.[10] On August 5, 2014, he was found dead hanging at the RIKEN institute. It is believed that he committed suicide.[11] Early life and educationYoshiki Sasai was born in 1962 in Hyogo, Japan. He received his medical degree from Kyoto University's School of Medicine in 1986. He was awarded a PhD from the Kyoto University's School of Medicine in 1993 and recruited to play the sport he loved, American football, for Kyoto University when he studied medicine there. Sasai was then a resident at Kobe Municipal General Hospital. CareerSubsequently Sasai worked as a research fellow at Edward M. De Robertis's laboratory at UCLA School of Medicine until 1996.[12] He became an associate professor at Kyoto University in 1996, and a full professor in 1998. In 2003, he moved to the RIKEN Center for Developmental Biology as Director of the organogenesis and neurogenesis group.[13] STAP controversySasai was a co-author on the paper describing the controversial stimulus-triggered acquisition of pluripotency or "STAP" cells.[13][14] A subsequent investigation cleared him of misconduct but criticized him for inadequate supervision of Haruko Obokata, the lead author of the paper.[15] Some media reports have linked the criticism and subsequent repercussions to his suicide at the RIKEN institute.[16][17] Awards and honoursIn 2010, Sasai received the Osaka Science Prize for his work on in vitro recapitulation of brain development. He was also the laureate of the 2012 Inoue Prize for Science.[18] See also
References1. ^{{Cite journal | doi = 10.1038/488444a| pmid = 22914148| title = Tissue engineering: The brainmaker| journal = Nature| volume = 488| issue = 7412| pages = 444–6| year = 2012| last1 = Cyranoski | first1 = D. }} {{Authority control }}{{DEFAULTSORT:Sasai, Yoshiki}}2. ^{{Cite journal | doi = 10.1038/513034a| title = Yoshiki Sasai (1962–2014) Stem-cell biologist who decoded signals in embryos| journal = Nature| volume = 513| issue = 7516| pages = 34| year = 2014| last1 = Alvarez-Buylla | first1 = Arturo}} 3. ^{{Scopus|id=7102587512}} 4. ^{{Cite journal | pmid = 11086981| year = 2000| author1 = Kawasaki| first1 = H| title = Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity| journal = Neuron| volume = 28| issue = 1| pages = 31–40| last2 = Mizuseki| first2 = K| last3 = Nishikawa| first3 = S| last4 = Kaneko| first4 = S| last5 = Kuwana| first5 = Y| last6 = Nakanishi| first6 = S| last7 = Nishikawa| first7 = S. I.| last8 = Sasai| first8 = Y | doi=10.1016/s0896-6273(00)00083-0}} 5. ^{{Cite journal | pmid = 8752213| pmc = 3070603| year = 1996| author1 = Piccolo| first1 = S| title = Dorsoventral patterning in Xenopus: Inhibition of ventral signals by direct binding of chordin to BMP-4| journal = Cell| volume = 86| issue = 4| pages = 589–98| last2 = Sasai| first2 = Y| last3 = Lu| first3 = B| last4 = De Robertis| first4 = E. M. | doi=10.1016/s0092-8674(00)80132-4}} 6. ^{{Cite journal | pmid = 8001117| pmc = 3082463| year = 1994| author1 = Sasai| first1 = Y| title = Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes| journal = Cell| volume = 79| issue = 5| pages = 779–90| last2 = Lu| first2 = B| last3 = Steinbeisser| first3 = H| last4 = Geissert| first4 = D| last5 = Gont| first5 = L. K.| last6 = De Robertis| first6 = E. M. | doi=10.1016/0092-8674(94)90068-X}} 7. ^{{Cite journal | last1 = Watanabe | first1 = K. | last2 = Ueno | first2 = M. | last3 = Kamiya | first3 = D. | last4 = Nishiyama | first4 = A. | last5 = Matsumura | first5 = M. | last6 = Wataya | first6 = T. | last7 = Takahashi | first7 = J. B. | last8 = Nishikawa | first8 = S. | last9 = Nishikawa | first9 = S. I. | last10 = Muguruma | doi = 10.1038/nbt1310 | first10 = K. | last11 = Sasai | first11 = Y. | title = A ROCK inhibitor permits survival of dissociated human embryonic stem cells | journal = Nature Biotechnology | volume = 25 | issue = 6 | pages = 681–686 | year = 2007 | pmid = 17529971 | pmc = }} 8. ^{{Cite journal | pmid = 8757128| year = 1996| author1 = Bouwmeester| first1 = T| title = Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer| journal = Nature| volume = 382| issue = 6592| pages = 595–601| last2 = Kim| first2 = S| last3 = Sasai| first3 = Y| last4 = Lu| first4 = B| last5 = De Robertis| first5 = E. M.| doi = 10.1038/382595a0}} 9. ^{{Cite journal | pmid = 1340473| year = 1992| author1 = Sasai| first1 = Y| title = Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split| journal = Genes & Development| volume = 6| issue = 12B| pages = 2620–34| last2 = Kageyama| first2 = R| last3 = Tagawa| first3 = Y| last4 = Shigemoto| first4 = R| last5 = Nakanishi| first5 = S | doi=10.1101/gad.6.12b.2620}} 10. ^{{cite web|last=Dvorsky|first=George|title=Scientists spark the growth of a human eye with stem cells|url=http://io9.com/5919186/scientists-spark-the-growth-of-a-human-eye-with-stem-cells|publisher=io9|quote=Moreover, Sasai's breakthrough marks the first time that such a complicated feat was done with human cells.|accessdate=6 July 2013}} 11. ^Asahi Shinbun Digital, August 4, 2014 12. ^{{cite web|title=Brief Resume of Dr. Yoshiki Sasai|url=http://www.riken.jp/en/pr/topics/2010/20100917/|website=News & Media|publisher=Riken|accessdate=26 August 2014}} 13. ^{{Cite journal | last1 = Obokata | first1 = Haruko | last2 = Wakayama | first2 = Teruhiko | last3 = Sasai | first3 = Yoshiki | year = 2014 | title = Stimulus-triggered fate conversion of somatic cells into pluripotency | journal = Nature | volume = 505 | issue = 7485 | pages = 641–647 | doi = 10.1038/nature12968 | pmid=24476887|display-authors=etal}} 14. ^{{cite journal | doi = 10.1038/nature13598 | title=Retraction: Stimulus-triggered fate conversion of somatic cells into pluripotency | journal=Nature | date=2014 | volume=511 | issue=7507 | pages=112 | first=Haruko | last=Obokata | pmid=24990753}} 15. ^[https://www.independent.co.uk/news/science/japanese-stem-cell-scientist-yoshiki-sasai-found-dead-in-apparent-suicide-9650050.html "Japanese stem cell scientist Yoshiki Sasai found dead in apparent suicide", The Independent, 5 August 2014]. Accessed 6 August 2014 16. ^{{cite news |url=https://online.wsj.com/articles/japanese-stem-cell-scientist-yoshiki-sasai-is-dead-1407206857 |title=Japanese Stem-Cell Scientist Yoshiki Sasai Is Dead |newspaper=Wall Street Journal |date=5 August 2014 }} 17. ^Collateral damage: How one misconduct case brought a biology institute to its knees. Nature, 30 April 2015, 520 (600-603). 18. ^1 {{cite web|title=Sayer Vision Research Lecture and Award 2012|url=http://www.nei.nih.gov/news/special/sasai.asp|publisher=National Eye Institute|accessdate=6 July 2013}} 10 : 1962 births|2014 deaths|Japanese biologists|Stem cell researchers|Suicides by hanging in Japan|Scientists who committed suicide|People from Hyōgo Prefecture|Kyoto University alumni|Kyoto University faculty|Riken personnel |
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