“YqeY protein domain”的意思、由来-开放百科全书

词条

YqeY protein domain

释义

Function
Homology
References

{{Infobox protein family
| Symbol = YqeY
| Name = YqeY
| image = PDB 1ng6 EBI.jpg
| width =
| caption = Structure of cytosolic protein of unknown function YqeY from Bacillus subtilis
| Pfam = PF09424
| Pfam_clan = CL0279
| InterPro = IPR019004
| SMART =
| PROSITE =
| MEROPS =
| SCOP = 1ng5
| TCDB =
| OPM family =
| OPM protein =
| CAZy =
| CDD =
}}

In molecular biology, YqeY is a type of protein domain of unknown function. It is thought to have a role in protein synthesis, facilitating the production of charged transfer RNA used in the process of translating mRNA into protein. It is present as a domain of glutaminyl-tRNA synthetase (GlnRS) in almost all eukaryotes.^[1]

Function

The YqeY domain has been found to be involved in the recognition of tRNA charged with the amino acid glutamine (tRNA-Gln).^[1] In some cases YqeY also increases the affinity of GlnRS for tRNA-Gln, but only when present in cis (that is, as part of the GlnRS polypeptide chain). However, the presence of YqeY as a standalone domain in organisms without GlnRS suggests that YqeY domains may have additional cellular functions.^[2]

Homology

This protein domain shares sequence homology with the C-terminal domain of GatB and GatE, the tRNA-binding subunits of bacterial and archaeal glutamine amidotransferases.^[2]

References

1. ^¹{{cite journal|last1=Hadd|first1=A|last2=Perona|first2=JJ|title=Coevolution of specificity determinants in eukaryotic glutamyl- and glutaminyl-tRNA synthetases.|journal=Journal of Molecular Biology|date=23 October 2014|volume=426|issue=21|pages=3619–33|pmid=25149203|doi=10.1016/j.jmb.2014.08.006}}
2. ^¹{{cite journal|vauthors=Deniziak M, Sauter C, Becker HD, Paulus CA, Giegé R, Kern D | title=Deinococcus glutaminyl-tRNA synthetase is a chimer between proteins from an ancient and the modern pathways of aminoacyl-tRNA formation. | journal=Nucleic Acids Res | year= 2007 | volume= 35 | issue= 5 | pages= 1421–31 | pmid=17284460 | doi=10.1093/nar/gkl1164 | pmc=1865053 }}

2 : Protein domains|Protein families

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