| 词条 | Zabofloxacin |
| 释义 |
| ImageFile = Zabofloxacin.svg | ImageSize = 200px | IUPACName = 1-Cyclopropyl-6-fluoro-7-[(8E)-8-(methoxyimino)-2,6-diazaspiro[3.4]oct-6-yl]-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid | OtherNames = DW-224a |Section1={{Chembox Identifiers | CASNo = 219680-11-2 | PubChem = 9952872 | ChemSpiderID = 8128482 | SMILES = Fc1c(nc2c(c1)C(=O)C(\\C(=O)O)=C/N2C3CC3)N5C\\C(=N\\OC)C4(CNC4)C5 | InChI = 1/C19H20FN5O4/c1-29-23-14-6-24(9-19(14)7-21-8-19)17-13(20)4-11-15(26)12(18(27)28)5-25(10-2-3-10)16(11)22-17/h4-5,10,21H,2-3,6-9H2,1H3,(H,27,28)/b23-14- | InChIKey = ZNPOCLHDJCAZAH-UCQKPKSFBL | StdInChI = 1S/C19H20FN5O4/c1-29-23-14-6-24(9-19(14)7-21-8-19)17-13(20)4-11-15(26)12(18(27)28)5-25(10-2-3-10)16(11)22-17/h4-5,10,21H,2-3,6-9H2,1H3,(H,27,28)/b23-14- | StdInChIKey = ZNPOCLHDJCAZAH-UCQKPKSFSA-N |Section2={{Chembox Properties | Formula = C19H20FN5O4 | MolarMass = 401.392 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}Zabofloxacin is an investigational fluoroquinolone antibiotic for multidrug-resistant infections due to Gram-positive bacteria.[1][2][3] It also has activity against Neisseria gonorrhoeae including strains that are resistant to other quinolone antibiotics.[4] Zabofloxacin was discovered by Dong Wha Pharmaceuticals and licensed to Pacific Beach BioSciences for development.[5] References1. ^{{cite journal | journal = Current Medical Research and Opinion | title = Comparison of pharmacokinetics between new quinolone antibiotics: the zabofloxacin hydrochloride capsule and the zabofloxacin aspartate tablet | date = October 2013 | volume = 29 | issue = 10 | pages = 1349–1355 | doi = 10.1185/03007995.2013.825591 |author1=HyeKyung Han |author2=Sung Eun Kim |author3=Kwang-Hee Shin |author4=Cheolhee Lim |author5=Kyoung Soo Lim |author6=Kyung-Sang Yu |author7=Joo-Youn Cho }} 2. ^{{cite journal | journal = Journal of Liquid Chromatography & Related Technologies | volume = 37 | issue = 3 | year = 2014 | title = Quantification Of Zabofloxacin In Rat Plasma Using Hplc-Uv Detector And Its Application To A Pharmacokinetic Study | doi = 10.1080/10826076.2012.745137 |author1=Jong-Hwa Lee |author2=Jung-Heun Ha |author3=Dae-Hun Park |author4=Dong-Rack Choi |author5=Gye-Won Lee |author6=Sung-Hoon Ahn |author7=Choong-Yong Kim |last-author-amp=yes | pages = 311–320}} 3. ^{{cite journal | journal = Drug Chem Toxicol | date = Nov 2004 | volume = 27 | issue = 4 | pages = 295–307 | title = Safety pharmacology of DW-224a, a novel fluoroquinolone antibiotic agent |vauthors=Kim EJ, Shin WH, Kim KS, Han SS | pmid= 15573468 | doi=10.1081/DCT-200039708}} 4. ^{{cite journal |vauthors=Jones RN, Biedenbach DJ, Ambrose PG, Wikler MA | title = Zabofloxacin (DW-224a) activity against Neisseria gonorrhoeae including quinolone-resistant strains | pmid= 18620833 | journal = Diagn Microbiol Infect Dis | year = 2008 | volume = 62 | issue = 1 | pages = 110–112 | doi = 10.1016/j.diagmicrobio.2008.05.010}} 5. ^{{cite news | url = http://globenewswire.com/news-release/2007/08/10/364043/124686/en/Pacific-Beach-BioSciences-and-Dong-Wha-Pharmaceuticals-Sign-Exclusive-License-Agreement-to-Develop-and-Commercialize-Zabofloxacin-PB-101-DW-224a.html | title = Pacific Beach BioSciences and Dong Wha Pharmaceuticals Sign Exclusive License Agreement to Develop and Commercialize Zabofloxacin (PB-101, DW-224a) | publisher = GlobeNewswire | date = August 10, 2007}} External links
1 : Fluoroquinolone antibiotics |
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