| 词条 | Zardaverine |
| 释义 |
| ImageFile = Zardaverine.svg | ImageSize = 200px | ImageAlt = | IUPACName = 3-[4-(Difluoromethoxy)-3-methoxyphenyl]-1H-pyridazin-6-one | OtherNames = | Section1 = {{Chembox Identifiers | CASNo = 101975-10-4 | PubChem = 5723 | ChemSpiderID = 5521 | InChI=1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17) | InChIKey= HJMQDJPMQIHLPB-UHFFFAOYSA-N | SMILES = COC1=C(C=CC(=C1)C2=NNC(=O)C=C2)OC(F)F |Section2={{Chembox Properties | C=12 | H=10 | F=2 | N=2 | O=3 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = | Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}Zardaverine is a dual-selective PDE3/4 phosphodiesterase inhibitor.[1] References1. ^{{cite journal | pmid = 22891752 | year = 2012 | last1 = Kümmerle | first1 = AE | last2 = Schmitt | first2 = M | last3 = Cardozo | first3 = SV | last4 = Lugnier | first4 = C | last5 = Villa | first5 = P | last6 = Lopes | first6 = AB | last7 = Romeiro | first7 = NC | last8 = Justiniano | first8 = H | last9 = Martins | first9 = MA | last10 = Fraga | first10 = CA | last11 = Bourguignon | first11 = JJ | last12 = Barreiro | first12 = EJ | title = Design, Synthesis, and Pharmacological Evaluation of N-Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally Active Phosphodiesterase-4 Inhibitors | volume = 55 | issue = 17 | pages = 7525–45 | doi = 10.1021/jm300514y | journal = Journal of Medicinal Chemistry}} {{Phosphodiesterase inhibitors}}{{organic-compound-stub}} 1 : Phosphodiesterase inhibitors |
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