| 词条 | Zeltiq Aesthetics |
| 释义 |
| name =Zeltiq | image = | image_caption = | caption = | trading_name = | type = Subsidiary | industry = Cryolipolysis | foundation = 2005 | founder = Mitchell Levinson | location_city = Pleasanton, California | location_country = United States | locations = | area_served = | key_people = Mark J. Foley, president and chief executive officer | products = CoolSculpting Procedure | brands = | production = | services = | revenue = | num_employees = | parent = Allergan plc | homepage = }} Zeltiq Aesthetics is a subsidiary of Allergan based in Pleasanton, California that markets and licenses devices used for cryolipolysis procedures. The company was founded in 2005 and raised $75 million in funding before going public in 2011. It was acquired by Allergan in 2017. HistoryZeltiq was founded in 2005 as Juniper Medical, Inc., by Mitch Levinson, who had previously led Thermage, a company that sold devices for radio frequency skin tightening.[1][2] The company changed its name to Zeltiq in July 2007.[3] The company developed a medical device to remove fat using a process called cryolipolysis, which it branded as "CoolSculpting". The device works by pulling a piece of flesh between two paddles, which cool it to below freezing and hold the temperature there for a half hour or so. Afterwards the flesh is frozen and numb; the numbness persists for two to three months.[4] For the clinics that use it, there is a high capital investment, and a room is tied up for a relatively long time.[4] It is intended for body contouring and not general weight loss. As of 2013, clinical trials have found that Cryolipolysis is moderately effective and has mostly mild and temporary side-effects.[5] Cryolipolysis was invented by Rox Anderson and colleagues[6] and Juniper Medical exclusively licensed patent filings on the invention from Massachusetts General Hospital when Juniper was founded.[2] An early prototype was created to test the method on pigs,[7] and preliminary results from a clinical trial were reported in 2009.[6] In 2009 Gordie Nye was appointed CEO, replacing Levinson, who remained on the board.[8][9] Zeltiq brought the device to market first for use in numbing the skin prior to dermatology procedures being done; Zeltiq received FDA clearance to market it for this purpose under the de novo pathway in 2010.[10][11] While the company did not market its device for removing fat at that time, doctors on its scientific board were talking about that use at scientific meetings and on TV news, and doctors started using it off-label for "body-sculpting".[12][13] The company made money from selling the machines, and also charged doctors for each procedure they did with the machine.[1] Because the procedure was elective surgery, people paid out of pocket for it.[12] By end of 2010, the company had raised $75 million in financing over four rounds of funding.[14] The device received FDA clearance to be marketed for removing love handle fat from people's sides in September 2010[20] and from the stomach in 2012.[15] It has also been approved by Health Canada and the European Union.[16] By late 2010 CoolSculpting had been introduced as a body-sculpting procedure in Europe, Asia and Canada.[17] By 2011, Zeltiq was approved to market the procedure in 46 countries.[18] CoolSculpting became popular in the United States around 2011.[15] In the first half of that year, Zeltiq's revenues grew four-fold to $31.6 million, though it was still operating at a small loss.[1][18] Zeltiq filed for an initial public offering later that year.[1][18] The IPO raised $91 million.[19] By January 2012, there had been 150,000 CoolSculpting treatments.[20] In 2014, Zeltiq introduced a new model of the CoolSculpting device obviating the suction cup and was cleared by the FDA for use on thighs.[21][22] As of 2014 the company's device led the market for cryolipolysis.[23][4][24][25] In February 2017 Zeltiq was purchased by Allergan for $2.48 billion.[26][27] References1. ^1 2 3 {{cite news|title=Pleasanton-based Zeltiq files for $115 million IPO|first=George|last=Avalos|newspaper=San Jose Mercury News|url=http://www.mercurynews.com/economy/ci_18471524|date=July 13, 2014|archiveurl=https://web.archive.org/web/20160304090200/https://www.mercurynews.com/economy/ci_18471524|archivedate=March 4, 2016}} 2. ^1 {{cite web |title=Zeltiq Amendment No. 8 to Form S-1 |url=https://www.sec.gov/Archives/edgar/data/1415336/000119312511273238/d197669ds1a.htm |publisher=Zeltiq via SEC Edgar |date=18 October 2011}} 3. ^{{citation|url=https://finance.yahoo.com/q/pr?s=ZLTQ|title=ZELTIQ Aesthetics, Inc.; Yahoo Profile|publisher=Yahoo|accessdate=January 28, 2015}} 4. ^1 2 {{cite book|author1=Kabir Sarbana|author2=Vijay K. Garg|title=Lasers in Dermatological Practice|url=https://books.google.com/books?id=OolPBQAAQBAJ&pg=PA356|date=July 1, 2014|publisher=JP Medical Ltd|isbn=978-93-5152-300-0|pages=356}} 5. ^{{cite journal | author = H. Ray Jalian & Mathew M. Avram | title = Cryolipolysis: a historical perspective and current clinical practice | journal = Seminars in Cutaneous Medicine and Surgery | volume = 32 | issue = 1 | pages = 31–34 | date=March 2013 | pmid = 24049927}} 6. ^1 {{cite news|newspaper=Skin & Allergy News|date=April 2009|title=Cryolipolysis on Track to Become First Cool Way to Remove Cellulite|first=Bruce|last=Jancin|pages=11|volume=40|url=https://www.mdedge.com/edermatologynews/article/9936/aesthetic-dermatology/cryolipolysis-track-become-first-cool-way-remove}} 7. ^{{cite book|author=Mathew Avram|title=Fat Removal: Invasive and Non-invasive Body Contouring|pages=102ff|url=https://books.google.com/books?id=MBp0BgAAQBAJ&pg=PA102|date=March 9, 2015|publisher=John Wiley & Sons|isbn=978-1-4443-3428-9}} 8. ^{{cite news|title=Zeltiq Aesthetics changes CEOs|date=September 29, 2009|first=Steven|last=Brown|newspaper=San Francisco Business Times|url=http://www.bizjournals.com/sanfrancisco/stories/2009/09/28/daily21.html?jst=pn_pn_lk|accessdate=January 28, 2015}} 9. ^{{cite news|title=Diary:Movers and Shakers|newspaper=Chemistry & Industry|date=November 9, 2009}} 10. ^{{cite web |title=DEN090002, K080521: Device Classification under Section 513(f)(2)(de novo) |url=https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpmn/denovo.cfm?ID=DEN090002 |publisher=FDA |accessdate=9 June 2018 |date=August 24, 2010}} 11. ^{{cite news|title=Who might be a candidate?|first=Karen|last=Weintraub|newspaper=The Boston Globe|date=March 29, 2010}} 12. ^1 {{cite news|title=Zap or Chill? Targeting Fat Without Surgery|url=https://www.nytimes.com/2010/02/04/fashion/04SKIN.html?pagewanted=all|newspaper=The New York Times|first=Catherine|last=Louis|date=February 4, 2010|page=E.1|accessdate=January 28, 2015}} 13. ^{{cite news|title=Beauty Spots|first=Catherine|last=Louis|date=June 30, 2010|url=https://www.nytimes.com/2010/07/01/fashion/01skinside.html|newspaper=The New York Times|accessdate=January 28, 2015}} 14. ^{{cite news|title=Zeltiq raises $25M for fat-reduction tech|date=June 3, 2010 | first=Maureen|last=Martino|url=http://www.fiercemedicaldevices.com/story/zeltiq-raises-25m-fat-reduction-tech/2010-06-03|accessdate=September 28, 2014|publisher=FierceMedicalDevices}} 15. ^1 2 {{cite journal|last1=Stevens|first1=W. G.|last2=Pietrzak|first2=L. K.|last3=Spring|first3=M. A.|title=Broad Overview of a Clinical and Commercial Experience With CoolSculpting|journal=Aesthetic Surgery Journal|volume=33|issue=6|year=2013|pages=835–846|issn=1090-820X|doi=10.1177/1090820X13494757}} 16. ^{{cite journal|last1=Boey|first1=Gerald E.|last2=Wasilenchuk|first2=Jennifer L.|title=Enhanced clinical outcome with manual massage following cryolipolysis treatment: A 4-month study of safety and efficacy|journal=Lasers in Surgery and Medicine|volume=46|issue=1|year=2014|pages=20–26|issn=0196-8092|doi=10.1002/lsm.22209|pmc=4265298}} 17. ^{{cite news|title=Lose those love handles|first=Jenny|last=Lee|date=August 23, 2010|url=http://www2.canada.com/vancouversun/news/archives/story.html?id=03bea10f-1bd3-4364-858d-3c8c414d79f6|newspaper=The Vancouver Sun|accessdate=September 28, 2014}} 18. ^1 2 {{cite news|title=Zeltiq Is Next Week's IPO|last=Cowan|first=Lynn|newspaper=Wall Street Journal|date=October 10, 2011|url=https://www.wsj.com/articles/SB10001424052970203499704576623233091006962|accessdate=January 28, 2015}} 19. ^{{cite news|title=Zeltiq Aesthetics Raises $91 Million in Initial Public Offering|first=Lee|last=Spears|url=https://www.bloomberg.com/news/2011-10-18/zeltiq-aesthetics-raises-91-million-in-initial-public-offering.html|publisher=Bloomberg|date=October 19, 2011|accessdate=September 28, 2014}} 20. ^{{cite news|last=Uken|first=Cindy|newspaper=The Billings Gazette|date=January 11, 2012|pages=C1|title=Non-invasive procedure popular method to get rid of unwanted 'love handles'|url=http://billingsgazette.com/lifestyles/health-med-fit/non-invasive-procedure-popular-method-to-get-rid-of-unwanted/article_375224bf-5783-5420-8ae8-caf6e2368a43.html|accessdate=September 28, 2014}} 21. ^{{cite news|title=Health: Procedure Now Approved To Melt Fat Off Thighs|date=May 27, 2014|publisher=CBS News|accessdate=October 11, 2014|url=http://philadelphia.cbslocal.com/2014/05/27/health-procedure-now-approved-to-melt-fat-off-thighs/|first=Stephanie|last=Stahl}} 22. ^{{cite news|title=Hot on 'cool' thighs, Zeltiq wins FDA clearance for fat-chilling procedure|date=April 14, 2014|url=http://www.bizjournals.com/sanfrancisco/blog/biotech/2014/04/zeltiq-aesthetics-zltq-fat-coolsculpting.html|publisher=BizJournals|accessdate=October 7, 2014|first=Ron|last=Leuty}} 23. ^{{cite news|title=Manhattan Analysts Lose Belly Fat|first=Gabrielle|last=Coppola|date=September 29, 2014|url=https://www.bloomberg.com/news/articles/2014-09-27/syneron-zaps-stock-analysts-fat-in-underdog-push|publisher=Bloomberg|accessdate=September 28, 2014}} 24. ^{{cite news|title=With cosmetic treatments, more men enlist in battle of the bulges|url=http://articles.latimes.com/2013/aug/16/health/la-he-body-contour-20130817|newspaper=Los Angeles Times|date=August 16, 2013|first=Melinda|last=Fulmer|accessdate=October 11, 2014}} 25. ^{{cite news|title=Freezing fat might shrink it|date=November 8, 2010 |first=Chris|last=Woolston|url=http://articles.latimes.com/2010/nov/08/health/la-he-skeptic-fat-freeze-20101108|newspaper=Los Angeles Times|accessdate=September 26, 2014}} 26. ^{{Cite news|url=https://finance.yahoo.com/news/allergan-acquire-zeltiq-best-class-130000562.html|title=Allergan to Acquire ZELTIQ, Best-in-Class Company in Fast-Growing Body Contouring Segment, for $2.47 Billion|access-date=2017-11-01|language=en-US}} 27. ^{{Cite news|url=https://www.bostonglobe.com/business/2017/04/14/meet-one-most-important-medical-entrepreneurs-you-never-heard/dfZFRbcdtjLcqyxci9vKlM/story.html|title=Meet one of the most important medical entrepreneurs you’ve never heard of|work=BostonGlobe.com|access-date=2017-11-01}} 4 : Medical technology companies of the United States|Companies established in 2005|Companies formerly listed on NASDAQ|Companies based in Pleasanton, California |
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