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词条 ZNF184
释义

  1. Domains and Structure

  2. References

  3. Further reading

{{Infobox_gene}}Zinc finger protein 184, also known as ZNF184, is a protein that in humans is encoded by the ZNF184 gene[1] on chromosome 6. It was first identified by Goldwurm et al. in 1996.[2]

The National Center for Biotechnology Information (NCBI) Gene database entry[1] for ZNF184 identifies conserved domains KRAB_A (Krüppel associated box) near the N-terminus and Zn-finger (Zinc finger) at the C-terminus of the translated protein. The former is associated with transcription repression[3] and the latter with DNA binding (see Zinc finger).

Domains and Structure

The figure below is a reformatted and annotated conceptual translation display of ZNF184s Consensus CDS.[4] CCDS displays exons in alternating black and blue font, with red indicating a residue coded across a splice boundary.

ZNF184 has 19 zinc finger motifs at the end of its final and longest exon. The figure shows regularity among the fingers in this protein, including the 2 columns of green-highlighted Cysteine residues and the 2 columns of blue-highlighted His residues which are the reason this type of zinc finger is called C2H2. Light grey highlighted columns (one with all F; one with mostly L, and F substitutions) are highly conserved hydrophobic residues within the zinc finger motif. The other light grey highlighted column (mostly K, with a similar R substitution) is an example of fairly strong conservation in the coil sections connecting adjacent fingers.

Near the N-terminus is a KRAB_A domain followed by a KRAB_B domain. KRAB_A has a shorter α-Helix followed by a longer α-Helix. The KRAB_A motif in a zinc finger protein is known to bind with a KAP-1 protein (aka TRIM28) to accomplish a transcription repressor function, however a gene so regulated by ZNF184 has yet to be identified. The length-11 finger helices are indicated, as well as the overlapping 7-residue section in each finger which binds targeted DNA (if the finger is functioning).

References

1. ^1 {{cite web | title=Entrez Gene: zinc finger protein 184 |url= https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7738 |accessdate = }}
2. ^{{cite journal |vauthors=Goldwurm S, Menzies ML, Banyer JL, Powell LW, Jazwinska EC |title=Identification of a novel Krueppel-related zinc finger gene (ZNF184) mapping to 6p21.3. |journal=Genomics |volume=40 |issue=3 |pages=486–9 |date=1997-03-15 |pmid=9073517 |doi=10.1006/geno.1996.4583 }}
3. ^{{cite journal |author=Peng H, Begg GE, Harper SL, Friedman JR, Speicher DW, Rauscher FJ 3rd |title=Biochemical Analysis of the Kruppel-associated Box (KRAB) Transcriptional Repression Domain |journal=Journal of Biological Chemistry |volume=275 |issue=24 |pages=18000–10 |date=2000-03-30 |pmid=10748030 |doi=10.1074/jbc.M001499200 }}
4. ^{{cite web |title=Consensus CDS: zinc finger protein 184 |url=https://www.ncbi.nlm.nih.gov/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&DATA=CCDS4624.1 |accessdate= }}

Further reading

{{refbegin | 2}}
  • {{cite book |title=Zinc Finger Proteins: From Atomic Contact to Cellular Function |series=Molecular Biology Intelligence Unit |editor1-first=Shiro |editor1-last=Iuchi |editor2-first=Natalie |editor2-last=Kuldell |publisher=Landes Bioscience/Eurekah.com and Kluwer Academic/Plenum Publishers |year=2005 |isbn=978-0-306-48229-8 }}
  • {{cite journal |vauthors=Shi J, Levinson DF, Duan J, etal |title=Common variants on chromosome 6p22.1 are associated with schizophrenia. |journal=Nature |volume=460 |issue= 7256 |pages= 753–7 |year= 2009 |pmid= 19571809 |doi= 10.1038/nature08192 |pmc=2775422}}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
  • {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1996 |pmid= 8889548 |doi= 10.1101/gr.6.9.791}}
  • {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 |pmc=1356129}}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241}}
  • {{cite journal |vauthors=Ravasi T, Suzuki H, Cannistraci CV, etal |title=An atlas of combinatorial transcriptional regulation in mouse and man. |journal=Cell |volume=140 |issue= 5 |pages= 744–52 |year= 2010 |pmid= 20211142 |doi= 10.1016/j.cell.2010.01.044 |pmc=2836267}}
  • {{cite journal |vauthors=Barbe L, Lundberg E, Oksvold P, etal |title=Toward a confocal subcellular atlas of the human proteome. |journal=Mol. Cell. Proteomics |volume=7 |issue= 3 |pages= 499–508 |year= 2008 |pmid= 18029348 |doi= 10.1074/mcp.M700325-MCP200 }}
{{refend}}{{PDB Gallery|geneid=7738}}
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