| 词条 | Zonampanel |
| 释义 |
| IUPAC_name = [7-(1H-Imidazol-1-yl)-6-nitro-2,3-dioxo-3,4-dihydro-1(2H)-quinoxalinyl]acetic acid | image = Zonampanel.svg | alt = Skeletal formula | width = 200 | image2 = Zonampanel molecule spacefill.png | alt2 = Space-filling model of zonampanel | CAS_number = 210245-80-0 | ATC_prefix = None | ATC_suffix = | PubChem = 148200 | DrugBank = | ChemSpiderID = 130649 | C=13 | H=9 | N=5 | O=6 | molecular_weight = 331.241 g/mol | smiles = c1cn(cn1)c2cc3c(cc2[N+](=O)[O-])[nH]c(=O)c(=O)n3CC(=O)O | StdInChI = 1S/C13H9N5O6/c19-11(20)5-17-8-4-9(16-2-1-14-6-16)10(18(23)24)3-7(8)15-12(21)13(17)22/h1-4,6H,5H2,(H,15,21)(H,19,20) | StdInChIKey = SPXYHZRWPRQLNS-UHFFFAOYSA-N | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | pregnancy_AU = | pregnancy_US = | pregnancy_category= | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = }}Zonampanel (INN, code name YM872) is a quinoxalinedione derivative drug and competitive antagonist of the AMPA receptor which was being investigated by Yamanouchi/Astellas Pharma as a neuroprotective drug for the treatment of ischemic stroke but never completed clinical trials.[1][2][3][4] In clinical trials, zonampanel produced severe side effects including hallucinations, agitation, and catatonia in patients, resulting in early termination of the trials.[5] References1. ^{{cite book|author=Kewal K. Jain|title=The Handbook of Neuroprotection|url=https://books.google.com/books?id=PGZ3Qqvjmo0C&pg=PA154|date=14 February 2011|publisher=Springer Science & Business Media|isbn=978-1-61779-049-2|pages=154–}} {{Ionotropic glutamate receptor modulators}}{{nervous-system-drug-stub}}2. ^{{cite book|author=Arunabha Ray, Kavita Gulati|title=Current Trends in Pharmacology|url=https://books.google.com/books?id=uB2vWIQBbxoC&pg=PA321|date=1 January 2007|publisher=I. K. International Pvt Ltd|isbn=978-81-88237-77-7|pages=321–}} 3. ^{{cite book|author=Stephen Waxman|title=Multiple Sclerosis As A Neuronal Disease|url=https://books.google.com/books?id=Eeqy733NZSEC&pg=PA245|date=27 May 2005|publisher=Academic Press|isbn=978-0-08-048941-4|pages=245–}} 4. ^{{cite book|author1=Santokh Gill|author2=Olga Pulido|title=Glutamate Receptors in Peripheral Tissue: Excitatory Transmission Outside the CNS|url=https://books.google.com/books?id=wcjiZ58mypIC&pg=PA37|date=31 January 2007|publisher=Springer Science & Business Media|isbn=978-0-306-48644-9|pages=37–}} 5. ^{{cite book|author=Akhlaq A. Farooqui|title=Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases|url=https://books.google.com/books?id=q_G5aon0WbAC&pg=PA73|date=2 September 2010|publisher=Springer Science & Business Media|isbn=978-1-4419-6652-0|pages=73–}} 7 : AMPA receptor antagonists|Imidazoles|Neuroprotective agents|Nitro compounds|Quinoxalines|Astellas Pharma|Acetic acids |
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