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词条 ZXDC
释义

  1. External links

  2. References

Zinc finger, X-linked, duplicated family member C (ZXDC) is a human CIITA-binding protein involved in the activation of major histocompatibility complex (MHC) class I and II.[1] For binding to occur, ZXDC must form an oligomeric complex with another copy of itself or with ZXDA, a related protein.[2] ZXDC is activated by sumolyation, a post-translational modification.[3]

External links

  • [https://www.ncbi.nlm.nih.gov/gene/79364 ZXDC at NIH NCBI]
  • [https://www.uniprot.org/uniprot/Q2QGD7 ZXDC at Uniprot]
  • [https://www.genecards.org/cgi-bin/carddisp.pl?gene=ZXDC ZXDC GeneCard]

References

1. ^{{Cite journal | last1 = Al-Kandari | first1 = W. | last2 = Jambunathan | first2 = S. | last3 = Navalgund | first3 = V. | last4 = Koneni | first4 = R. | last5 = Freer | first5 = M. | last6 = Parimi | first6 = N. | last7 = Mudhasani | first7 = R. | last8 = Fontes | first8 = J. D. | doi = 10.1016/j.molimm.2006.02.029 | title = ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription | journal = Molecular Immunology | volume = 44 | issue = 4 | pages = 311–321 | year = 2007 | pmid = 16600381 | pmc =1624858 }}
2. ^{{Cite journal | last1 = Al-Kandari | first1 = W. | last2 = Koneni | first2 = R. | last3 = Navalgund | first3 = V. | last4 = Aleksandrova | first4 = A. | last5 = Jambunathan | first5 = S. | last6 = Fontes | first6 = J. D. | doi = 10.1016/j.jmb.2007.04.033 | title = The Zinc Finger Proteins ZXDA and ZXDC Form a Complex that Binds CIITA and Regulates MHC II Gene Transcription | journal = Journal of Molecular Biology | volume = 369 | issue = 5 | pages = 1175–1187 | year = 2007 | pmid = 17493635 | pmc =1963517 }}
3. ^{{Cite journal | last1 = Jambunathan | first1 = S. | last2 = Fontes | first2 = J. D. | doi = 10.1515/BC.2007.106 | title = Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain | journal = Biological Chemistry | volume = 388 | issue = 9 | pages = 965–972 | year = 2007 | pmid = 17696781 | pmc = }}
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1 : Human proteins

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