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词条 ZZZ3
释义

  1. See also

  2. References

  3. Further reading

{{Infobox_gene}}ZZ-type zinc finger-containing protein 3 is a protein that in humans is encoded by the ZZZ3 gene.[1]

==Model organisms==

Model organisms have been used in the study of ZZZ3 function. A conditional knockout mouse line, called Zzz3tm1a(EUCOMM)Wtsi[5][6] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[7][8][9]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[3][10] Twenty four tests were carried out on mutant mice and two significant abnormalities were observed.[3] No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice and no further abnormal phenotypes were identified.[3]

See also

  • ZZ zinc finger

References

1. ^{{cite web | title = Entrez Gene: zinc finger, ZZ-type containing 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=26009| accessdate = 2011-08-30}}
2. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MAMV/citrobacter-challenge/ |title=Citrobacter infection data for Zzz3 |publisher=Wellcome Trust Sanger Institute}}
3. ^1 2 3 {{cite journal | doi = 10.1111/j.1755-3768.2010.4142.x | title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice | year = 2010 | author = Gerdin AK | journal = Acta Ophthalmologica | volume = 88 | pages = 925–7 }}
4. ^Mouse Resources Portal, Wellcome Trust Sanger Institute.
5. ^{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Zzz3 |title=International Knockout Mouse Consortium}}
6. ^{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4432089 |title=Mouse Genome Informatics}}
7. ^{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}
8. ^{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}
9. ^{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}
10. ^{{cite journal | vauthors = van der Weyden L, White JK, Adams DJ, Logan DW | title = The mouse genetics toolkit: revealing function and mechanism | journal = Genome Biology | volume = 12 | issue = 6 | pages = 224 | year = 2011 | pmid = 21722353 | pmc = 3218837 | doi = 10.1186/gb-2011-12-6-224 }}

Further reading

  • {{cite journal | vauthors = Guelman S, Suganuma T, Florens L, Swanson SK, Kiesecker CL, Kusch T, Anderson S, Yates JR, Washburn MP, Abmayr SM, Workman JL | title = Host cell factor and an uncharacterized SANT domain protein are stable components of ATAC, a novel dAda2A/dGcn5-containing histone acetyltransferase complex in Drosophila | journal = Molecular and Cellular Biology | volume = 26 | issue = 3 | pages = 871–82 | date = Feb 2006 | pmid = 16428443 | pmc = 1347012 | doi = 10.1128/MCB.26.3.871-882.2006 }}
  • {{cite journal | vauthors = Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y | title = An atlas of combinatorial transcriptional regulation in mouse and man | journal = Cell | volume = 140 | issue = 5 | pages = 744–52 | date = Mar 2010 | pmid = 20211142 | pmc = 2836267 | doi = 10.1016/j.cell.2010.01.044 }}
{{refend}}{{gene-1-stub}}

1 : Genes mutated in mice
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