| 词条 | 17α-Methyl-19-norprogesterone |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = | image = 17α-Methyl-19-norprogesterone.svg | width = 200px | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | class = Progestin; Progestogen | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = | CAS_supplemental = | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = | IUPHAR_ligand = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 34253447 | UNII = | KEGG = | ChEBI = | ChEMBL = | synonyms = H-3510; 17α-Methyl-19-norpregn-4-ene-3,20-dione; (17β)-17-Acetyl-17-methylestr-4-en-3-one | C=21 | H=30 | O=2 | molecular_weight = 314.462 g/mol | SMILES = O=C(C)[C@](C)1CC[C@]([H])2[C@@]([H])3CCC4=CC(CCC4C3CC[C@@]21C)=O | StdInChI_Ref = | StdInChI = 1S/C21H30O2/c1-13(22)20(2)11-9-19-18-6-4-14-12-15(23)5-7-16(14)17(18)8-10-21(19,20)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18+,19-,20+,21-/m0/s1 | StdInChIKey_Ref = | StdInChIKey = SMHQTBXJLXZKNT-VXAANUECSA-N }}17α-Methyl-19-norprogesterone (developmental code name H-3510), also known as 17α-methyl-19-norpregn-4-ene-3,20-dione, is a progestin which was never marketed.[1][2][3] It is a derivative of progesterone, and is the combined derivative of 17α-methylprogesterone and 19-norprogesterone.[1] The drug is the parent compound of a subgroup of the 19-norprogesterone group of progestins, which includes demegestone (the δ9 derivative), promegestone (the δ9 and 21-methyl derivative), and trimegestone (the δ9, 21-methyl, and 21-hydroxyl derivative).[4] See also
References1. ^1 {{cite journal|last1=Weiss|first1=M.J.|last2=Schaub|first2=R.E.|last3=Allen|first3=G.R.|last4=Poletto|first4=J.F.|last5=Pidacks|first5=V.|last6=Conrow|first6=R.B.|last7=Coscia|first7=C.J.|title=The formation of steroid enolate anions by reductive procedures|journal=Tetrahedron|volume=20|issue=2|year=1964|pages=357–372|issn=0040-4020|doi=10.1016/S0040-4020(01)93223-5}} {{Progesterone receptor modulators}}{{DEFAULTSORT:Methyl-19-norprogesterone, 17α-}}{{Steroid-stub}}{{Genito-urinary-drug-stub}}2. ^{{cite journal | vauthors = Raynaud JP, Philibert D, Azadian-Boulanger G | title = Progesterone-Progestin receptors | journal = Basic Life Sci. | volume = 4 | issue = PART A | pages = 143–60 | date = 1974 | pmid = 4374925 | doi = | url = }} 3. ^{{cite journal | vauthors = Delettré J, Mornon JP, Lepicard G, Ojasoo T, Raynaud JP | title = Steroid flexibility and receptor specificity | journal = J. Steroid Biochem. | volume = 13 | issue = 1 | pages = 45–59 | date = January 1980 | pmid = 7382482 | doi = | url = }} 4. ^{{cite journal | vauthors = Kuhl H | title = Pharmacology of estrogens and progestogens: influence of different routes of administration | journal = Climacteric | volume = 8 Suppl 1 | issue = | pages = 3–63 | year = 2005 | pmid = 16112947 | doi = 10.1080/13697130500148875 | url = }} 4 : Abandoned drugs|Diketones|Norpregnanes|Progestogens |
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