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词条 17β-Aminoestrogen
释义

  1. References

17β-Aminoestrogens are a group of synthetic, steroidal estrogens derived from estradiol which have an amine substitution in place of the hydroxyl group at the C17β position.[1][2] They are estrogenic similarly,[1] but, unlike estradiol, show sustained anticoagulant activity that appears to be mediated by non-genomic mechanisms.[2] As such, it is thought that they may have a reduced risk of venous thromboembolism.[2] The 17β-aminoestrogens include the base or parent estrogen aminoestradiol (AE2)[3] and the extended-chain derivatives butolame, hexolame, pentolame, prodiame, and prolame.[1][2] They are a homologous series of steroids.[4]

References

1. ^{{cite journal | vauthors = Lemini C, Rubio-Póo C, Silva G, García-Mondragón J, Zavala E, Mendoza-Patiño N, Castro D, Cruz-Almanza R, Mandoki JJ | title = Anticoagulant and estrogenic effects of two new 17 beta-aminoestrogens, butolame [17 beta-(4-hydroxy-1-butylamino)-1,3,5(10)-estratrien-3-ol] and pentolame [17 beta-(5-hydroxy-1-pentylamino)-1,3,5(10)-estratrien-3-ol] | journal = Steroids | volume = 58 | issue = 10 | pages = 457–61 | year = 1993 | pmid = 8256254 | doi = 10.1016/0039-128x(93)90002-5| url = }}
2. ^{{cite journal | vauthors = González G, Alvarado-Vasquez N, Fernández-G JM, Cruz-Robles D, Del Valle L, Pinzón E, Torres I, Rodriguez E, Zapata E, Gómez-Vidales V, Montaño LF, de la Peña A | title = The antithrombotic effect of the aminoestrogen prolame (N-(3-hydroxy-1,3,5(10)-estratrien-17B-YL)-3-hydroxypropylamine) is linked to an increase in nitric oxide production by platelets and endothelial cells | journal = Atherosclerosis | volume = 208 | issue = 1 | pages = 62–8 | year = 2010 | pmid = 19615684 | doi = 10.1016/j.atherosclerosis.2009.06.017 | url = }}
3. ^{{cite journal | vauthors = Lemini C, Rubio-Póo C, Franco Y, Jaimez R, Avila ME, Medina M, Lemus AE | title = In vivo profile of the anticoagulant effect of 17ß-amino-1,3,5(10)estratrien-3-ol | journal = Eur. J. Pharmacol. | volume = 700 | issue = 1-3 | pages = 210–6 | year = 2013 | pmid = 23305838 | doi = 10.1016/j.ejphar.2012.12.030 | url = }}
4. ^{{cite journal | vauthors = Rubio-Póo C, Lemini C, Silva G, García-Mondragón J, Zavala E, Castro D, Mendoza-Patiño N, Mandoki JJ | title = Comparison of the time course of anticoagulant and estrogenic effects of prolame, butolame, pentolame and hexolame, a homologous series of 17 beta-amino estrogens | journal = Proc. West. Pharmacol. Soc. | volume = 36 | issue = | pages = 143–7 | year = 1993 | pmid = 8378368 | doi = | url = }}
{{Estrogen receptor modulators}}{{DEFAULTSORT:Aminoestrogens, 17β-}}{{steroid-stub}}{{genito-urinary-drug-stub}}

4 : Amines|Anticoagulants|Estranes|Synthetic estrogens

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