| 词条 | 18-Deoxyaldosterone |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = | image = 18-Deoxyaldosterone.svg | width = | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = | CAS_supplemental = | class = Antimineralocorticoid | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = 188963 | IUPHAR_ligand = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = | UNII = | KEGG = | ChEBI = | ChEMBL = | C=21 | H=28 | O=4 | molecular_weight = 344.451 g/mol | SMILES = C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@@H]4CC5([C@H]3CC[C@@H]5C(=O)CO)CO4 | StdInChI_Ref = | StdInChI = 1S/C21H28O4/c1-20-7-6-13(23)8-12(20)2-3-14-15-4-5-16(17(24)10-22)21(15)9-18(19(14)20)25-11-21/h8,14-16,18-19,22H,2-7,9-11H2,1H3/t14-,15-,16+,18-,19+,20-,21?/m0/s1 | StdInChIKey_Ref = | StdInChIKey = ZEBLTAXSHAKMDJ-QBSCYWOBSA-N | synonyms = 11β,18-epoxy-21-hydroxypregn-4-ene-3,20-dione }}18-Deoxyaldosterone is a steroidal antimineralocorticoid with mixed agonist–antagonist but predominantly antagonistic activity at the mineralocorticoid receptor.[1] References1. ^{{cite journal|last1=Duax|first1=William L.|last2=Griffin|first2=Jane F.|last3=Strong|first3=Phyllis D.|last4=Funder|first4=John W.|last5=Ulick|first5=Stanley|title=Molecular structure of 18-deoxyaldosterone and its relationship to receptor binding and activity|journal=Journal of the American Chemical Society|volume=104|issue=25|year=1982|pages=7291–7293|issn=0002-7863|doi=10.1021/ja00389a063}} {{Mineralocorticoid receptor modulators}}{{DEFAULTSORT:Deoxyaldosterone, 18-}}{{steroid-stub}} 4 : Alcohols|Antimineralocorticoids|Diketones|Pregnanes |
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