| 词条 | 19-Nordehydroepiandrosterone |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = (3S,8R,9S,10R,13S,14S)-3-hydroxy-13-methyl-2,3,4,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-one | image = 19-Nordehydroepiandrosterone.svg | width = 235px | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = By mouth | class = Androgen; anabolic steroid; progestogen | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 17916-75-5 | CAS_supplemental = | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = 53990402 | IUPHAR_ligand = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 277545 | UNII = | KEGG = | ChEBI = | ChEMBL = | synonyms = {{ubl|19-Nor-DHEA|19-Nor-5-dehydroepiandrosterone|19-Nor-5-DHEA|Estr-5-en-3β-ol-17-one|19-Norandrost-5-en-3β-ol-17-one|3β-Hydroxyestr-5-en-17-one}} | C=18 | H=25 | O=2 | molecular_weight = 274.404 g/mol | SMILES = C[C@]12CC[C@@H]3[C@H]4CC[C@@H](CC4=CC[C@H]3[C@@H]1CCC2=O)O | StdInChI_Ref = | StdInChI = 1S/C18H26O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h2,12-16,19H,3-10H2,1H3/t12-,13-,14+,15+,16-,18-/m0/s1 | StdInChIKey_Ref = | StdInChIKey = KELRVUIFMYCLHB-MTLKIPAASA-N |drug_name=|alt=|caption=|type=|MedlinePlus=|licence_EU=|licence_US=}}19-Nordehydroepiandrosterone (19-nor-DHEA), or 19-nor-5-dehydroepiandrosterone (19-nor-5-DHEA), is an estrane (19-norandrostane) steroid which was never marketed.[1][2] It is the combined derivative of the androgen/anabolic steroid nandrolone (19-nortestosterone) and the androgen prohormone dehydroepiandrosterone (DHEA, or more specifically 5-DHEA).[1][2] Related compounds include 19-nor-5-androstenediol, bolandiol (19-nor-4-androstenediol), and bolandione (nor-4-androstenedione), which are all known orally active prohormones of nandrolone.[2][3][4] 19-Nor-DHEA may occur as a metabolite of bolandione and related steroids.[2] See also
References1. ^1 {{cite journal | vauthors = Poortman J, Vroegindewey-Jie D, Thijssen JH, Schwarz F | title = Relative binding affinity of androstane and C-19-nor-androstane-steroids for the estradiol-receptor in human myometrial and mammary cancer tissue | journal = Mol. Cell. Endocrinol. | volume = 8 | issue = 1 | pages = 27–34 | date = July 1977 | pmid = 881104 | doi = 10.1016/0303-7207(77)90015-6 | url = }} {{Androgen receptor modulators}}{{Estrogen receptor modulators}}{{Progesterone receptor modulators}}{{DEFAULTSORT:Nordehydroepiandrosterone, 19-}}{{Steroid-stub}}{{Genito-urinary-drug-stub}}2. ^1 2 3 {{cite journal | vauthors = Uralets VP, Gillette PA | title = Over-the-counter Δ5 anabolic steroids 5-androsen-3,17-dione; 5-androsten-3β, 17β-diol; dehydroepiandrosterone; and 19-nor-5-androsten-3,17-dione: excretion studies in men | journal = J Anal Toxicol | volume = 24 | issue = 3 | pages = 188–93 | date = April 2000 | pmid = 10774538 | doi = 10.1093/jat/24.3.188 | url = }} 3. ^{{cite book|author1=Detlef Thieme|author2=Peter Hemmersbach|title=Doping in Sports|url=https://books.google.com/books?id=R-hIC-caIn8C&pg=PA137|date=18 December 2009|publisher=Springer Science & Business Media|isbn=978-3-540-79088-4|pages=137–}} 4. ^{{cite book|author=Jehuda Yinon|title=Advances in Forensic Applications of Mass Spectrometry|url=https://books.google.com/books?id=T0vGENZVDaoC&pg=PA138|date=29 December 2003|publisher=CRC Press|isbn=978-0-203-99828-1|pages=138–}} 8 : Abandoned drugs|Alcohols|Androgens and anabolic steroids|Designer drugs|Estranes|Estrogens|Prodrugs|Progestogens |
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