Two ships in the United States Navy have been named USS Macedonian.
The first {{USS|Macedonian|1810}} was a 38-gun sailing frigate, originally {{HMS|Macedonian}} of the Royal Navy, captured by Stephen Decatur in the War of 1812.
The second {{USS|Macedonian|1836}} was rebuilt from the keel of the first Macedonian and placed in service in 1836.