| 词条 | 21-Deoxycortisone |
| 释义 |
| ImageFile = 21-Deoxycortisone.svg | ImageSize = 200px | ImageAlt = | IUPACName = (8S,9S,10R,13S,14S,17R)-17-Acetyl-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione | OtherNames = 21-Desoxycortisone; 11-Keto-17α-hydroxyprogesterone; 17α-Hydroxy-11-ketoprogesterone; 17α-Hydroxypregn-4-en-3,11,20-trione | Section1 = {{Chembox Identifiers | CASNo = 1882-82-2 | ChemSpiderID = 92310 | KEGG = C14478 | PubChem = 102178 | SMILES = CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC(=O)[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C)O | StdInChI = 1S/C21H28O4/c1-12(22)21(25)9-7-16-15-5-4-13-10-14(23)6-8-19(13,2)18(15)17(24)11-20(16,21)3/h10,15-16,18,25H,4-9,11H2,1-3H3/t15-,16-,18+,19-,20-,21-/m0/s1 | StdInChIKey = PUKLDDOGISCFCP-JSQCKWNTSA-N | UNII = 60A688J7YQ | Section2 = {{Chembox Properties | C=21 | H=28 | O=4 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = | Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}21-Deoxycortisone, also known as 21-desoxycortisone, 11-keto-17α-hydroxyprogesterone, or 17α-hydroxypregn-4-ene-3,11,20-trione, is a naturally occurring, endogenous steroid and minor intermediate and metabolite in corticosteroid metabolism. It is related to 21-deoxycortisol (11β,17α-dihydroxyprogesterone) and is reversibly formed from it by 11β-hydroxysteroid dehydrogenase, analogously to the reversible formation of cortisone from cortisol.[1] 21-Deoxycortisone can be transformed into cortisone by 21-hydroxylase.[2] See also
References1. ^{{cite journal | vauthors = Homma K, Hasegawa T, Takeshita E, Watanabe K, Anzo M, Toyoura T, Jinno K, Ohashi T, Hamajima T, Takahashi Y, Takahashi T, Matsuo N | title = Elevated urine pregnanetriolone definitively establishes the diagnosis of classical 21-hydroxylase deficiency in term and preterm neonates | journal = J. Clin. Endocrinol. Metab. | volume = 89 | issue = 12 | pages = 6087–91 | year = 2004 | pmid = 15579762 | doi = 10.1210/jc.2004-0473 | url = }} {{Endogenous steroids}}{{DEFAULTSORT:Deoxycortisone, 21-}}{{steroid-stub}}2. ^{{cite journal | vauthors = ROSENFELD G, UNGAR F, DORFMAN RI, PINCUS G | title = Irradiation and adrenal steroidogenesis: steroid transformations by irradiated isolated perfused calf adrenals | journal = Endocrinology | volume = 56 | issue = 1 | pages = 24–9 | year = 1955 | pmid = 13220521 | doi = 10.1210/endo-56-1-24 | url = }} 4 : Corticosteroids|Human metabolites|Pregnanes|Triketones |
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