| 词条 | 2,8-Dihydroxyhexahydrochrysene |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = | image = 2,8-Dihydroxyhexahydrochrysene.svg | width = | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = | CAS_supplemental = | ATC_prefix = None | ATC_suffix = | PubChem = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = | C=18 | H=18 | O= 2 | molecular_weight = | smiles = | StdInChI_Ref = | StdInChI = | StdInChIKey_Ref = | StdInChIKey = | synonyms = }}2,8-Dihydroxyhexahydrochrysene (2,8-DHHHC) is a synthetic, nonsteroidal weak estrogen with approximately 1/2,000th the estrogenic potency of the structurally-related estrogen diethylstilbestrol.[1][2][3] It is said to be intermediate in structure between estradiol and hexestrol, but conversely to both of them, is drastically less potent in comparison.[3] See also
References1. ^{{cite book|author1=Philipp Y. Maximov|author2=Russell E. McDaniel|author3=V. Craig Jordan|title=Tamoxifen: Pioneering Medicine in Breast Cancer|url=https://books.google.com/books?id=p-W5BAAAQBAJ&pg=PA4|date=23 July 2013|publisher=Springer Science & Business Media|isbn=978-3-0348-0664-0|pages=4–}} {{Estrogenics}}{{DEFAULTSORT:Dihydroxyhexahydrochrysene, 2,8-}}{{genito-urinary-drug-stub}}2. ^{{cite book|author=Virgil Craig Jordan|title=Estrogen/antiestrogen Action and Breast Cancer Therapy|url=https://books.google.com/books?id=7WmLZfGXST0C&pg=PA22|year=1986|publisher=Univ of Wisconsin Press|isbn=978-0-299-10480-1|pages=22–}} 3. ^1 {{cite journal|last1=Wilds|first1=A. L.|last2=Sutton|first2=Reid E.|title=Cyclic Analogs of Hexestrol in the Chrysene Series|journal=The Journal of Organic Chemistry|volume=16|issue=9|year=1951|pages=1371–1379|issn=0022-3263|doi=10.1021/jo50003a006}} 1 : Synthetic estrogens |
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