| 词条 | 4-Fluoroisobutyrfentanyl |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = N-(4-Fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-isobutanamide | image = 4-Fluoroisobutyrfentanyl.svg | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_US = Schedule I | legal_UK = Class A | legal_CA = Schedule I | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 244195-32-2 | ATC_prefix = | ATC_suffix = | PubChem = 100974914 | DrugBank_Ref = | DrugBank = | ChemSpiderID = | ChEBI_Ref = | ChEBI = | UNII = | C=23 | H=29 | F=1 | N=2 | O=1 | molecular_weight = | smiles = CC(C)C(=O)N(C1CCN(CC1)CCC2=CC=CC=C2)C3=CC=C(C=C3)F | StdInChI = 1S/C23H29FN2O/c1-18(2)23(27)26(21-10-8-20(24)9-11-21)22-13-16-25(17-14-22)15-12-19-6-4-3-5-7-19/h3-11,18,22H,12-17H2,1-2H3 | StdInChIKey = OZDOSQNUJIXEOR-UHFFFAOYSA-N | synonyms = }}4-Fluoroisobutyrylfentanyl (also known as 4-FIBF and p-FIBF) is an opioid analgesic that is an analog of butyrfentanyl and structural isomer of 4-Fluorobutyrfentanyl and has been sold online as a designer drug.[1][2][3][4] It is closely related to 4-fluorofentanyl, which has an EC50 value of 4.2 nM for the human μ-opioid receptor.[5] Side effectsSide effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.[6] Legality4-Fluoroisobutyrylfentanyl is a Schedule I controlled substance in the United States.[7] In the UK, it is a Class A drug. In Canada, it is a Schedule I drug. See also
References1. ^{{cite web | url=https://www.caymanchem.com/product/19795 | title=FIBF | publisher=Cayman Chemical}} {{Opioid receptor modulators}}{{DEFAULTSORT:Fluoroisobutyrfentanyl, 4-}}2. ^{{cite journal|first1=Shimpei|last1=Watanabe|first2=Svante|last2=Vikingsson|first3=Markus|last3=Roman|first4=Henrik|last4=Green|title=In Vitro and In Vivo Metabolite Identification Studies for the New Synthetic Opioids Acetylfentanyl, Acrylfentanyl, Furanylfentanyl, and 4-Fluoro-Isobutyrylfentanyl|journal=The AAPS Journal|date=July 2017|pages=1102–1122|volume=19|issue=4|doi=10.1208/s12248-017-0070-z|pmid=28382544|first5=Robert|last5=Kronstrand|first6=Ariane|last6=Wohlfarth}} 3. ^{{cite journal|first1=Anders|last1=Helander|first2=Matilda|last2=Bäckberg|first3=Patrick|last3=Signell|first4=Olof|last4=Beck|title=Intoxications involving acrylfentanyl and other novel designer fentanyls – results from the Swedish STRIDA project|journal=Clinical Toxicology|date=3 July 2017|issn=1556-3650|pages=589–599|volume=55|issue=6|pmid=28349714|doi=10.1080/15563650.2017.1303141}} 4. ^{{cite journal|first1=Kraig E.|last1=Strayer|first2=Heather M.|last2=Antonides|first3=Matthew P.|last3=Juhascik|first4=Raminta|last4=Daniulaityte|title=LC-MS/MS-Based Method for the Multiplex Detection of 24 Fentanyl Analogues and Metabolites in Whole Blood at Sub ng mL–1 Concentrations|journal=ACS Omega|date=2018|issn=2470-1343|pages=514–523|volume=3|issue=1|doi=10.1021/acsomega.7b01536|pmid=29399650|pmc=5793031|first5=Ioana E.|last5=Sizemore}} 5. ^{{cite journal|first1=Chris|last1=Ulens|first2=Maurits Van|last2=Boven|first3=Paul|last3=Daenens|first4=Jan|last4=Tytgat|title=Interaction of p-Fluorofentanyl on Cloned Human Opioid Receptors and Exploration of the Role of Trp-318 and His-319 in μ-Opioid Receptor Selectivity|url=http://jpet.aspetjournals.org/content/294/3/1024.full|journal=Journal of Pharmacology and Experimental Therapeutics|date=1 September 2000|issn=1521-0103|pages=1024–1033|volume=294|issue=3|pmid=10945855}} 6. ^{{cite journal|first1=Jane|last1=Mounteney|first2=Isabelle|last2=Giraudon|first3=Gleb|last3=Denissov|first4=Paul|last4=Griffiths|title=Fentanyls: Are we missing the signs? Highly potent and on the rise in Europe|url=http://www.sciencedirect.com/science/article/pii/S0955395915000973|journal=International Journal of Drug Policy|date=July 2015|pages=626–631|volume=26|issue=7|doi=10.1016/j.drugpo.2015.04.003|pmid=25976511}} 7. ^{{cite web | url = https://www.deadiversion.usdoj.gov/schedules/orangebook/d_cs_drugcode.pdf | title = Controlled Substances by DEA Drug Code Number | publisher = Drug Enforcement Agency}} 7 : Synthetic opioids|Designer drugs|Anilides|Piperidines|Propionamides|Mu-opioid agonists|Fluoroarenes |
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