| 词条 | 4-Fluorophenibut |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = 4-Amino-3-(4-fluorophenyl)butanoic acid | image = 4-Fluorophenibut.svg | width = | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = By mouth | class = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 52237-19-1 | CAS_supplemental = | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = 103611 | IUPHAR_ligand = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 93547 | UNII = | KEGG = | ChEBI = | ChEMBL = | synonyms = CGP-11130; β-(4-Fluorophenyl)-γ-aminobutyric acid; β-(4-Fluorophenyl)-GABA; Baflofen; Fluorophenibut; F-Phenibut; Fluoribut | C=10 | H=12 | F=1 | N=1 | O=2 | SMILES = C1=CC(=CC=C1C(CC(=O)O)CN)F | StdInChI_Ref = | StdInChI = 1S/C10H12FNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14) | StdInChIKey_Ref = | StdInChIKey = QWHXHLDNSXLAPX-UHFFFAOYSA-N }}4-Fluorophenibut (developmental code name CGP-11130; also known as β-(4-fluorophenyl)-γ-aminobutyric acid or β-(4-fluorophenyl)-GABA) is a GABAB receptor agonist which was never marketed.[1] It is selective for the GABAB receptor over the GABAA receptor (IC50 = 1.70 µM and > 100 µM, respectively).[1] The drug is a GABA analogue and is closely related to baclofen (β-(4-chlorophenyl)-GABA), tolibut (β-(4-methylphenyl)-GABA), and phenibut (β-phenyl-GABA).[1] It is less potent as a GABAB receptor agonist than baclofen but more potent than phenibut.[1] The substance is sometimes referred to as 4F-phenibut or F-phenibut and colloquially as fluorobut. References1. ^1 2 3 {{cite journal | vauthors = Bowery NG, Hill DR, Hudson AL | title = Characteristics of GABAB receptor binding sites on rat whole brain synaptic membranes | journal = Br. J. Pharmacol. | volume = 78 | issue = 1 | pages = 191–206 | year = 1983 | pmid = 6297646 | pmc = 2044790 | doi = | url = }} {{GABA receptor modulators}}{{DEFAULTSORT:Fluorophenibut, 4-}}{{Nervous-system-drug-stub}} 6 : Amines|Carboxylic acids|Experimental drugs|Fluoroarenes|GABA analogues|GABAB receptor agonists |
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