| 词条 | AAAP family |
| 释义 |
The Amino Acid/Auxin Permease (AAAP) Family (TC# 2.A.18) is a family of secondary carrier proteins, a member of the APC Superfamily that includes hundreds of proteins from plants, animals, fungi and lower eukaryotes. Six AAAPs in A. thaliana are well characterized and transport neutral and charged amino acids with varying specificities and affinities.[1][2] FunctionAmong animal AAAP family members are numerous growth regulating System A and System N isoforms, each exhibiting distinctive tissue and subcellular localizations. The different isoforms also exhibit different relative affinities for the amino acid substrates. Some catalyze H+ antiport and can function bidirectionally. Since Systems A are electrogenic which Systems N are not, the amino acid:cation stoichiometries may differ.[2][3][4][5] References1. ^{{cite journal|last1=Fischer|first1=WN|last2=Loo|first2=DD|last3=Koch|first3=W|last4=Ludewig|first4=U|last5=Boorer|first5=KJ|last6=Tegeder|first6=M|last7=Rentsch|first7=D|last8=Wright|first8=EM|last9=Frommer|first9=WB|title=Low and high affinity amino acid H+-cotransporters for cellular import of neutral and charged amino acids.|journal=Plant Journal|date=March 2002|volume=29|issue=6|pages=717–31|pmid=12148530|doi=10.1046/j.1365-313x.2002.01248.x}} {{CCBYSASource|sourcepath=http://www.tcdb.org/search/result.php?tc=2.A.18|sourcearticle=The Amino Acid/Auxin Permease (AAAP) Family|revision=699866824}}{{membrane-protein-stub}}2. ^1 {{cite web|last1=Saier|first1=MH Jr.|title=2.A.18 The Amino Acid/Auxin Permease (AAAP) Family|url=http://www.tcdb.org/search/result.php?tc=2.A.18|website=Transporter Classification Database|publisher=Saier Lab Bioinformatics Group}} 3. ^{{cite journal|last1=Chaudhry|first1=FA|last2=Krizaj|first2=D|last3=Larsson|first3=P|last4=Reimer|first4=RJ|last5=Wreden|first5=C|last6=Storm-Mathisen|first6=J|last7=Copenhagen|first7=D|last8=Kavanaugh|first8=M|last9=Edwards|first9=RH|title=Coupled and uncoupled proton movement by amino acid transport system N.|journal=EMBO Journal|date=December 17, 2001|volume=20|issue=24|pages=7041–51|pmid=11742981|doi=10.1093/emboj/20.24.7041|pmc=125789}} 4. ^{{cite journal|last1=Chaudhry|first1=FA|last2=Schmitz|first2=D|last3=Reimer|first3=RJ|last4=Larsson|first4=P|last5=Gray|first5=AT|last6=Nicoll|first6=R|last7=Kavanaugh|first7=M|last8=Edwards|first8=RH|title=Glutamine uptake by neurons: interaction of protons with system a transporters.|journal=Journal of Neuroscience|date=January 1, 2002|volume=22|issue=1|pages=62–72|pmid=11756489}} 5. ^{{cite journal|last1=Varoqui|first1=H|last2=Zhu|first2=H|last3=Yao|first3=D|last4=Ming|first4=H|last5=Erickson|first5=JD|title=Cloning and functional identification of a neuronal glutamine transporter.|journal=Journal of Biological Chemistry|date=February 11, 2000|volume=275|issue=6|pages=4049–54|pmid=10660562|doi=10.1074/jbc.275.6.4049}} 3 : Protein domains|Protein families|Membrane proteins |
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