| 词条 | ACE inhibitor and thiazide combination |
| 释义 |
An ACE inhibitor and thiazide combination is a drug combination used to treat hypertension. They are given by mouth. Examples{{Drugbox| drug_name = Quinapril/hydrochlorothiazide | type = combo | component1 = Quinapril | class1 = Angiotensin converting enzyme inhibitor | component2 = Hydrochlorothiazide | class2 = Thiazide diuretic | tradename = Accuretic | MedlinePlus = | Drugs.com = {{Drugs.com|MTM|accuretic}} | licence_EU = | licence_US = | pregnancy_AU = | pregnancy_US = D | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = Rx-only | legal_status = | dependency_liability = | routes_of_administration = | CAS_number = | ATC_prefix = C09 | ATC_suffix = BA06 | PubChem = | KEGG = D10278 | ChemSpiderID = 30797396 }}{{Drugbox | verifiedrevid = 447439314 | drug_name = Lisinopril/hydrochlorothiazide | type = combo | component1 = Lisinopril | class1 = ACE inhibitor | component2 = Hydrochlorothiazide | class2 = Thiazide diuretic | tradename = | MedlinePlus = a601070 | pregnancy_AU = | pregnancy_US = D | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = Rx-only | routes_of_administration = Oral | ATC_prefix = C09 | ATC_suffix = BA03 | KEGG = D10268 }}
Fosinopril/hydrochlorothiazide{{Drugbox| drug_name = Fosinopril/hydrochlorothiazide | type = combo | component1 = Fosinopril | class1 = Angiotensin converting enzyme inhibitor | component2 = Hydrochlorothiazide | class2 = Thiazide diuretic | tradename = Monopril HCT | MedlinePlus = | licence_EU = | licence_US = | pregnancy_AU = | pregnancy_US = | pregnancy_category = C (1st trimester); D (2nd & 3rd trimesters) | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = Rx | dependency_liability = | routes_of_administration = Oral | CAS_number = | ATC_prefix =C09 | ATC_suffix =BA09 | PubChem = | KEGG = }}Fosinopril/hydrochlorothiazide (trade name Monopril HCT) has a boxed warning about its risk to cause morbidity and mortality in the baby when being used during pregnancy (2nd and 3rd trimesters).[4] FDA modified its labeling on February, 2009 to include a precaution of drug interaction with gold. "Nitritoid reactions (symptoms include facial flushing, nausea, vomiting and hypotension) have been reported rarely in patients on therapy with injectable gold (sodium aurothiomalate) and concomitant ACE inhibitor therapy including Monopril/Monopril HCT."[5] See also
References1. ^Accuretic {{Drugs.com|MTM|accuretic}} {{Agents acting on the renin-angiotensin system}}2. ^{{cite web|url=https://www.drugs.com/mtm/prinzide.html|title=Prinzide Uses, Side Effects & Warnings - Drugs.com|website=drugs.com}} 3. ^{{cite web|url=https://www.drugs.com/zestoretic.html|title=Zestoretic: Uses, Dosage & Side Effects - Drugs.com|website=drugs.com}} 4. ^{{cite web|title=fosinopril/hydrochlorothiazide (Rx) - Contraindications & Cautions|url=http://reference.medscape.com/drug/fosinopril-hydrochlorothiazide-342334#5|publisher=Medscape|accessdate=13 December 2013}} 5. ^{{cite web|title=Monopril HCT (fosinopril/hydrochlorothiazide) 20/12.5mg and 10/12.5mg Tablets February 2009|url=http://www.fda.gov/Safety/MedWatch/SafetyInformation/Safety-RelatedDrugLabelingChanges/ucm133086.htm|publisher=FDA}} 3 : Diuretics|Combination drugs|ACE inhibitors |
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