“ACE model”的意思、由来-开放百科全书

The ACE model is a statistical model commonly used to analyze the results of twin studies. It aims to decompose sources of phenotypic variation into three categories: additive genetic variance (A), common (or shared) environmental factors (C), and specific (or nonshared) environmental factors plus measurement error (E).^[1] It is widely used in genetic epidemiology and behavioural genetics.^[2]^[3] The basic ACE model relies on several assumptions, including the absence of assortative mating,^[4] that there is no genetic dominance or epistasis,^[5] that all genetic effects are additive, and the absence of gene-environment interactions.^[3] In order to address these limitations, several variants of the ACE model have been developed, including an ACE-β model, which emphasizes the identification of causal effects,^[3] and the ACDE model, which accounts for the presence of dominant genetic effects.^[6]

1. ^{{Cite journal |last=Germine |first=Laura |last2=Russell |first2=Richard |last3=Bronstad |first3=P. Matthew |last4=Blokland |first4=Gabriëlla A.M. |last5=Smoller |first5=Jordan W. |last6=Kwok |first6=Holum |last7=Anthony |first7=Samuel E. |last8=Nakayama |first8=Ken |last9=Rhodes |first9=Gillian |date=October 2015 |title=Individual Aesthetic Preferences for Faces Are Shaped Mostly by Environments, Not Genes |journal=Current Biology |volume=25 |issue=20 |pages=2684–2689 |doi=10.1016/j.cub.2015.08.048 |issn=0960-9822 |pmc=4629915 |pmid=26441352}}
2. ^{{Cite encyclopedia |title=ACE Model |publisher=John Wiley & Sons, Ltd |location=Chichester, UK |last=Maes |first=Hermine H. |date=2005-10-15 |language=en |doi=10.1002/0470013192.bsa002 |isbn=978-0470860809 |journal=Encyclopedia of Statistics in Behavioral Science}}
3. ^¹²{{Cite journal |last=Kohler |first=Hans-Peter |last2=Behrman |first2=Jere R. |last3=Schnittker |first3=Jason |date=2011 |title=Social science methods for twins data: integrating causality, endowments, and heritability |journal=Biodemography and Social Biology |volume=57 |issue=1 |pages=88–141 |issn=1948-5565 |pmc=3158495 |pmid=21845929}}
4. ^{{Cite journal |last=Beauchamp |first=Jonathan P. |last2=Cesarini |first2=David |last3=Johannesson |first3=Magnus |last4=Lindqvist |first4=Erik |last5=Apicella |first5=Coren |date=2010-07-06 |title=On the sources of the height–intelligence correlation: New insights from a bivariate ACE model with assortative mating |journal=Behavior Genetics |language=en |volume=41 |issue=2 |pages=242–252 |doi=10.1007/s10519-010-9376-7 |issn=0001-8244 |pmc=3044837 |pmid=20603722}}
5. ^{{Cite book |url=https://books.google.com/books?id=FShOTUIfxwwC |title=Family Matters: Designing, Analysing and Understanding Family Based Studies in Life Course Epidemiology |last=Lawlor |first=Debbie A. |last2=Lawlor |first2=Deborah A. |last3=Mishra |first3=Gita D. |date=2009-04-02 |publisher=OUP Oxford |isbn=9780199231034 |pages=252–3 |language=en}}
6. ^{{Cite journal |last=Wang |first=Xueqin |last2=Guo |first2=Xiaobo |last3=He |first3=Mingguang |last4=Zhang |first4=Heping |date=2011-02-09 |title=Statistical Inference in Mixed Models and Analysis of Twin and Family Data |journal=Biometrics |language=en |volume=67 |issue=3 |pages=987–995 |doi=10.1111/j.1541-0420.2010.01548.x |issn=0006-341X |pmc=3129472 |pmid=21306354}}

See also

References

Further reading