| 词条 | Adam Bogdanove |
| 释义 |
}}{{Infobox scientist | name = Adam Bogdanove | image = | image_size = | alt = | caption = | birth_date = 1964 | birth_place = | death_date = | death_place = | resting_place = | resting_place_coordinates = | residence = | citizenship = | nationality = American | fields = Plant Pathology, Bioengineering | workplaces = Cornell University, Boyce Thompson Institute | alma_mater = Yale University, Cornell University | thesis_title = | thesis_url = | thesis_year = | academic_advisors = | notable_students = | known_for = TAL effectors, Genome editing | author_abbrev_bot = | author_abbrev_zoo = | influences = | influenced = |awards = | signature = | signature_alt = | website = [https://pppmb.cals.cornell.edu/people/adam-bogdanove] | footnotes = | spouse = }} Adam J. Bogdanove (born 1964) is a Professor of Plant Pathology at Cornell University.[1] He is most notable for his central role in the development of TAL effector based DNA targeting reagents, following his discovery of TAL effector modularity with Matthew Moscou in 2009.[2] Since, he has been a leader in the field, pioneering applications in genome editing and contributing one of the most widely used methods for designing custom TAL effectors using Golden Gate Cloning.[3] Bogdanove is now widely recognized for revolutionizing the area of DNA targeting, along with scientists such as Jennifer Doudna and Emmanuelle Charpentier. EducationBogdanove earned his Bachelor of Science degree in Biology from Yale University in 1987, and his Ph.D. in Plant Pathology from Cornell University in 1997,[4] going on to do postdoctoral work at Purdue University. Research and careerBogdanove's present research focuses on the pathogen Xanthomonas oryzae and its interactions with species of rice. A significant portion of his work uncovered the mechanisms by which TAL effectors increase disease susceptibility by manipulating host gene expression. Further work has paved the way for genome editing technologies like CRISPR and their applications, which use modified proteins to induce targeted changes in plant and animal DNA sequences. References1. ^{{cite web|title=People in PPPMB: Adam Bogdanove|url=https://pppmb.cals.cornell.edu/people/adam-bogdanove|website=Cornell University CALS|publisher=Cornell University|accessdate=12 April 2016}} {{DEFAULTSORT:Bogdanove, Adam}}2. ^{{cite journal |author=Moscou MJ, Bogdanove AJ |title=A simple cipher governs DNA recognition by TAL effectors |journal=Science |volume=326 |issue=5959 |pages=1501 |date=December 2009 |pmid=19933106 |doi=10.1126/science.1178817 |url= |bibcode=2009Sci...326.1501M}} 3. ^{{Cite journal | last1 = Cermak | first1 = T. | last2 = Doyle | first2 = E. L. | last3 = Christian | first3 = M. | last4 = Wang | first4 = L. | last5 = Zhang | first5 = Y. | last6 = Schmidt | first6 = C. | last7 = Baller | first7 = J. A. | last8 = Somia | first8 = N. V. | last9 = Bogdanove | first9 = A. J. | last10 = Voytas | first10 = D. F. | title = Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting | doi = 10.1093/nar/gkr218 | journal = Nucleic Acids Research | volume = 39 | issue = 12 | pages = e82 | year = 2011 | pmid = 21493687| pmc =3130291 }} 4. ^{{cite web|title=People in PPPMB: Adam Bogdanove|url=https://pppmb.cals.cornell.edu/people/adam-bogdanove|website=Cornell University CALS|publisher=Cornell University|accessdate=12 April 2016}} 6 : 1964 births|Living people|Cornell University College of Agriculture and Life Sciences alumni|Cornell University faculty|Place of birth missing (living people)|Yale University alumni |
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